Gold nanoparticles as efficient sensors in colorimetric detection of toxic metal ions: A review

Priyadarshini, Eepsita; Pradhan, Nilotpala

doi:10.1016/j.snb.2016.06.081

Cited by 524 publications

(204 citation statements)

References 134 publications

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“…[1][2][3] Silver nanoparticles (AgNPs) have been extensively used in antimicrobial applications, specifically, as antibacterial agents. 4,5 The traditional synthesis of AuNPs involves the use of chemical reducing agents to convert metal salts to metallic nanoparticles via a reduction reaction.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Park¹,

Ahn²,

Park³

2017

IJN

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Mangosteen ( Garcinia mangostana ) pericarp waste extract was used to synthesize gold and silver nanoparticles by a green strategy. The extract was both a reducing and stabilizing agent during synthesis. Phytochemical screening of the extract was conducted to obtain information regarding the presence/absence of primary and secondary metabolites in the extract. The in vitro antioxidant activity results demonstrated that the extract had excellent antioxidant activity, which was comparable to a standard (butylated hydroxy toluene). Spherical gold nanoparticles (gold nanoparticles green synthesized by mangosteen pericarp extract [GM-AuNPs]) with an average size of 15.37±3.99 to 44.20±16.99 nm were observed in high-resolution transmission electron microscopy (HR-TEM) images. Most interestingly, the silver nanoparticles (silver nanoparticles green synthesized by mangosteen pericarp extract [GM-AgNPs]) had asymmetric nanodumbbell shapes where one tail grew from a spherical head. The average head size was measured to be 13.65±5.07 to 31.08±3.99 nm from HR-TEM images. The hydrodynamic size of both nanoparticles tended to increase with increasing extract concentration. Large negative zeta potentials (−18.92 to −34.77 mV) suggested that each nanoparticle solution possessed excellent colloidal stability. The reaction yields were 99.7% for GM-AuNPs and 82.8% for GM-AgNPs, which were assessed by inductively coupled plasma optical emission spectroscopy. A high-resolution X-ray diffraction pattern confirmed the face-centered cubic structure of both nanoparticles. Based on phytochemical screening and Fourier transform infrared spectra, the hydroxyl functional groups of carbohydrates, flavonoids, glycosides, and phenolic compounds were most likely involved in a reduction reaction of gold or silver salts to their corresponding nanoparticles. The in vitro cytotoxicity (based on a water-soluble tetrazolium assay) demonstrated that GM-AgNPs were toxic to both A549 (a human lung cancer cell) and NIH3T3 (a mouse fibroblast cell). The cytotoxicity of GM-AgNPs on A549 cells was related to apoptotic cell death. However, GM-AuNPs did not show any significant cytotoxicity to either cell. These results suggest that GM-AuNPs have the potential to be drug delivery vehicles or carriers for pharmaceutical and biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Park¹,

Ahn²,

Park³

2017

IJN

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“…DNA oligonucleotides were synthesized and purified by high performance liquid chromatography (Takara Biotechnology Co., Ltd, Dalian, China). The sequence of 8‐17 DNAzyme and GR5 DNAzyme were reported by many earlier studies . All sequences and their modifications at the 3′‐end are listed in Table .…”

Section: Methodsmentioning

confidence: 99%

A highly sensitive and colorimetric biosensor based on magnetic nano‐DNAzyme for detection of lead (II) ion in real water samples

Rong

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND Colorimetric biosensors based on DNAzyme provide convenient and selective means for the detection of lead ion (Pb2+), which are critically important to prevent lead exposure and poisoning. However, they still remain challenging because of their limitation of sensitivity (only nmol L‐1 level) and practical application. Herein, we design a highly sensitive, selective, simple, and quantitative platform for direct Pb2+ detection based on the magnetic nano‐DNAzyme in real water samples. RESULTS Magnetic beads were modified with enzyme strand of DNAzyme to work as solid phase carriers and hybridized with DNAzyme's substrate strand/horseradish peroxidase molecules double‐codified gold nanoparticles to form a stable magnetic nano‐DNAzyme complex. Under the optimized reaction conditions, the magnetic nano‐DNAzyme had a quantitative detection range from 102 to 108 pmol L‐1, a limit of detection of 32 pmol L‐1 and high selectivity for Pb2+ over other metal ions with an assay time less than 1 h. In addition, this method showed enhanced pH stability and long service life, and had a potential to detect other metal ions only by changing corresponding DNAzyme specific to them. Finally, the magnetic nano‐DNAzyme platform was demonstrated to work well in direct Pb2+ detection in real water samples. CONCLUSION The magnetic nano‐DNAzyme system for colorimetric detection of Pb2+ showed high sensitivity and selectivity, simple, enhanced pH stability with long service life in practical application. © 2018 Society of Chemical Industry

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“…Nowadays, gold nanoparticles are extensively applied in chemical, biological, and biomedical research . The concept of nanoparticle‐assisted sample preparation, pre‐concentration, separation, and sensing plays important roles in many analytical procedures.…”

Section: Introductionmentioning

confidence: 99%

Functionalized gold nanoparticles for sample preparation: A review

Liu

Lämmerhofer

2019

Electrophoresis

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Sample preparation is a crucial step for the reliable and accurate analysis of both small molecule and biopolymers which often involves processes such as isolation, pre‐concentration, removal of interferences (purification), and pre‐processing (e.g., enzymatic digestion) of targets from a complex matrix. Gold nanoparticle (GNP)‐assisted sample preparation and pre‐concentration has been extensively applied in many analytical procedures in recent years due to the favorable and unique properties of GNPs such as size‐controlled synthesis, large surface‐to‐volume ratio, surface inertness, straightforward surface modification, easy separation requiring minimal manipulation of samples. This review article primarily focuses on applications of GNPs in sample preparation, in particular for bioaffinity capture and biocatalysis. In addition, their most common synthesis, surface modification and characterization methods are briefly summarized. Proper surface modification for GNPs designed in accordance to their target application directly influence their functionalities, e.g., extraction efficiencies, and catalytic efficiencies. Characterization of GNPs after synthesis and modification is worthwhile for monitoring and controlling the fabrication process to ensure proper quality and functionality. Parameters such as morphology, colloidal stability, and physical/chemical properties can be assessed by methods such as surface plasmon resonance, dynamic light scattering, ζ‐potential determinations, transmission electron microscopy, Taylor dispersion analysis, and resonant mass measurement, among others. The accurate determination of the surface coverage appears to be also mandatory for the quality control of functionality of the nanoparticles. Some promising applications of (functionalized) GNPs for bioanalysis and sample preparation are described herein.

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Gold nanoparticles as efficient sensors in colorimetric detection of toxic metal ions: A review

Cited by 524 publications

References 134 publications

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

A highly sensitive and colorimetric biosensor based on magnetic nano‐DNAzyme for detection of lead (II) ion in real water samples

Functionalized gold nanoparticles for sample preparation: A review

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