Gold nanoparticles capped DHPMs for meliorate detection of antiretroviral drug: Azidothymidine

Bhardwaj, Geetika; Kaur, Randeep; Kaur, Navneet; Singh, Narinder

doi:10.1016/j.talanta.2022.123591

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…33−36 biological activities. 37,38 And more recently, DHPMs has been used in diversiform life science research for structure modifications, and prominent pharmaceutical activities have been affirmed, especially in anticancer and antioxidant agents, 39−43 the meliorate detection of antiretroviral drug, 44 and Helicobacter pylori urease inhibitors. 45 Therefore, the development of new catalysts with high efficiency for the synthesis of DHPMs has gained increasing interest, and many novel catalytic materials, including nanoparticles and nanocomposites 46−48 and metallic oxides (i.e., oxidovanadium and oxidoniobium) 49,50 on different types of supports, have been attempted in the three-component Biginelli reactions.…”

Section: ■ Introductionmentioning

confidence: 99%

“…As important multicomponent reactions, the Biginelli reactions involve a one-pot condensation of three common reagents to afford 3,4-dihydropyrimidin-2-(1 H )-ones (DHPMs). − Currently, the application of the Biginelli reaction to prepare DHPMs has attracted renewed attention because the derivatives of DHPMs can identify promising biological activities. , And more recently, DHPMs has been used in diversiform life science research for structure modifications, and prominent pharmaceutical activities have been affirmed, especially in anticancer and antioxidant agents, − the meliorate detection of antiretroviral drug, and Helicobacter pylori urease inhibitors . Therefore, the development of new catalysts with high efficiency for the synthesis of DHPMs has gained increasing interest, and many novel catalytic materials, including nanoparticles and nanocomposites − and metallic oxides (i.e., oxidovanadium and oxidoniobium) , on different types of supports, have been attempted in the three-component Biginelli reactions.…”

Section: Introductionmentioning

confidence: 99%

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Ultrahigh-Performance Fiber-Supported Iron-Based Ionic Liquid for Synthesizing 3,4-Dihydropyrimidin-2-(1H)-ones in a Cleaner Manner

Zhang,

Shi,

et al. 2024

Langmuir

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Herein, a fiber-supported iron-based ionic liquid as a type of fibrous catalyst has been developed for the synthesis of bioactive 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) via threecomponent Biginelli reactions in a cleaner manner. The described fibrous catalyst was obtained from the commercially available polyetheretherketone (PEEK) fiber by postfunctionalization processes and was characterized and analyzed in detail by means of diversified technologies. Furthermore, the fiber-supported ironbased ionic liquids could mediate the classical three-component Biginelli reactions to proceed smoothly to gain a variety of substituted DHPMs with yields of up to 99%. The superior catalytic activities of the fibrous catalyst were ascribed to the quasi-homogeneous medium by ionic liquids generated in the surface layer of the PEEK fiber, which could afford an appropriate reaction zone and could further be available for the aggregation of substrates to facilitate the three-component reaction. Notably, the fibrous catalyst is available for recycling over 10 runs just by a pair of tweezers, and the operational procedure was capable of enlarging the catalytic system to the gram-scale without any performance degradation, which provided a cleaner manner to take advantage of the iron-based catalyst in organic synthesis with potential industrialization prospects.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrahigh-Performance Fiber-Supported Iron-Based Ionic Liquid for Synthesizing 3,4-Dihydropyrimidin-2-(1H)-ones in a Cleaner Manner

Zhang,

Shi,

et al. 2024

Langmuir

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“…The Biginelli reaction, a kind of MCRs, is a promising synthetic strategy to access storerooms of compound dihydropyrimidinones (DHPMs) by the one-pot multicomponent condensation of urea, β-keto ester, and aldehyde . Its products have a vital role in drug discovery research due to the several pharmacological and therapeutic functionality such as calcium channel blockers, anticancer, antibacterial, antihypertensive, antimalarial, antiviral, and antitubercular . Generally speaking, this reaction is facilitated by either protic or Lewis acids.…”

Section: Introductionmentioning

confidence: 99%

Iron–Organic Framework Nanoparticle-Supported Tungstosilicic Acid as a Catalyst for the Biginelli Reaction

Zhang

Liu

et al. 2022

ACS Appl. Nano Mater.

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In this work, a metal−organic framework with an octahedral morphology supported by a tungstosilicic acid (TSA) nanocatalyst has been successfully synthesized through a postsynthetic modification approach and referred to as TSA/MIL-88B. The as-prepared catalyst was efficiently obtained from Biginelli reactions among benzaldehyde, urea, and 1,3-dicarbonyl compound. Depending on the synergistic effect of exposed metal iron sites and the supported Brønsted acid sites, the hybrid materials exhibited high catalytic activity. Additionally, the environmentally friendly nanocatalyst could be recycled seven times with a little reduction in the catalytic performance. This study also provides a way for the application of such porous organic polymer functionalization in organic synthesis.

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Evaluation of Electrochemical Behavior and Antioxidant Activity of Seleno‐Dihydropyrimidinones and Chloro‐Dihydropyrimidinones

Eltz da Rosa,

Oliveira de Sousa,

Alf da Rosa

et al. 2024

ChemistrySelect

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Organic compounds with potential antioxidant activity have attracted special attention of researchers and they have been widely studied in several areas, including pharmacology and medicinal chemistry. In this context, electrochemistry through cyclic voltammetry becomes a fast and efficient tool for the characterization of the antioxidant potential of these compounds. Herein, a study was carried out on the electrochemical behavior of seleno‐dihydropyrimidinones and chloro‐dihydropyrimidinones via cyclic voltammetry in the presence of acetonitrile. By employing this approach, the characterization of the oxidation processes and the determination of antioxidant activities of the target molecules was disclosed. It was also proposed a comparison of the results obtained with the antioxidant activity of the 2,2‐diphenyl‐1‐picrylhydrazyl radical. Among the evaluated compounds, four molecules exhibited significant antioxidant capacities which were efficiently detected by 2,2‐diphenyl‐1‐picrylhydrazyl radical assay and by cyclic voltammetry when measuring the charges transferred until 0.9 V vs Fc+/Fc.

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Gold nanoparticles capped DHPMs for meliorate detection of antiretroviral drug: Azidothymidine

Cited by 6 publications

References 59 publications

Ultrahigh-Performance Fiber-Supported Iron-Based Ionic Liquid for Synthesizing 3,4-Dihydropyrimidin-2-(1H)-ones in a Cleaner Manner

Ultrahigh-Performance Fiber-Supported Iron-Based Ionic Liquid for Synthesizing 3,4-Dihydropyrimidin-2-(1H)-ones in a Cleaner Manner

Iron–Organic Framework Nanoparticle-Supported Tungstosilicic Acid as a Catalyst for the Biginelli Reaction

Evaluation of Electrochemical Behavior and Antioxidant Activity of Seleno‐Dihydropyrimidinones and Chloro‐Dihydropyrimidinones

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