Gold nanoparticles modulate the steroidogenic and apoptotic pathway in a buffalo granulosa cell model

Lyngdoh, Erica Lawai; Nayan, Varij; Vashisht, Monika; Kumari, Sneha; Bhardwaj, Arun; Bhatia, Tanvi; Dalal, Jasmer; Pawaria, Shikha; Onteru, Suneel Kumar; Sikka, P.; Singh, Dheer

doi:10.1007/s10529-020-02896-z

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…Recent studies have suggested that the buffalo granulosa cells co-incubated with AuNPs with two different concentrations (210 9 and 210 10 AuNPs/ml) for 24 h. In the buffalo ovarian granulosa cells, the gold nanoparticles did not show oxidative stress. AuNPs can regulate the endocrine system by modulating the steroidogenic and apoptotic pathways (Lyngdoh et al, 2020). Similarly, in vivo experiments showed that AgNPs modulated steroidogenic pathway mRNA genes (HSD3β, CYP17A1 and CYP19A1) expression in ovarian follicles in laying chickens (Katarzyñska-Banasik et al, 2021).…”

Section: Ovarian Steroidogenesismentioning

confidence: 93%

Nanotechnology for Animal Sciences-New Insights and Pitfalls: A Review

Kumar¹,

Singh²,

Chauhan³

et al. 2023

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Nanotechnology applications are increasingly recognized as potential tools in animal sciences, veterinary medicine, drug delivery, disease diagnosis and vaccine development. The nanoparticles and their therapeutic trends provide a realistic glimpse of current and future trends in veterinary diagnosis and medicine. Nanotechnology is ascribed to provide new horizons for applications in molecular biology and biotechnology by revolutionizing almost every field of veterinary or animal sciences by offering novel nano-scale tools and materials which can benefit society in all walks of life. The nanoparticles have been employed in diverse biological and non-biological functions. Nanomaterials can contribute to the farm animals for long-term sustainability by increasing the quality and quantity of safe, healthy and functional animal products. Although there are advantages while using nanoparticles to enhance performance and heal diseases in livestock, it is universally recognized that some nanoparticles can cause toxic and adverse effects on living creatures. Apart from that, the promise of nanoscience in veterinary medicine and livestock reproduction is yet to be explored. A few studies have been made on the uses of nanoparticles in veterinary medicine, livestock health and reproduction. Awareness is needed about the possible toxic effects and hazards, which could harm the living world. To improve the efficient and accurate diagnosis and treatment of animal diseases, more sophisticated research on nanomaterials and nanomedicines is required.

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Section: Ovarian Steroidogenesismentioning

confidence: 93%

Nanotechnology for Animal Sciences-New Insights and Pitfalls: A Review

Kumar¹,

Singh²,

Chauhan³

et al. 2023

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show abstract

“…In particular, progesterone production was significantly increased, probably as a consequence of increased mitochondria permeability due to particle movement across the cells and other membranes. Such a disturbance of the mitochondrial membranes and homeostasis generates ROS that, in turn, causes oxidative stress and even cell death by stimulating the expression of pro-apoptotic genes [ 84 , 85 ]. Different results were obtained by Tiedemann et al, because in their experiments AuNPs showed (after 46 h) no detrimental effects on porcine cumulus–oocyte complexes regardless of size, surface ligands or concentration [ 86 ].…”

Section: Np-induced Toxicity In Ovary and Oocytesmentioning

confidence: 99%

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Aloisi

Rossi

Colafarina

et al. 2022

IJERPH

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Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.

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Tuning the Organic Electrochemical Transistor (OECT) Threshold Voltage with Monomer Blends

Priyadarshini,

Li,

Rilemark

et al. 2024

Adv Elect Materials

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A novel approach is introduced to modulate the threshold voltage of organic electrochemical transistors (OECTs) that are fabricated by electropolymerizing the channel material between the source and drain electrodes. To achieve this, we adjust the ratio of two water‐soluble tri‐thiophene monomers, which share the same backbone, but present either anionic or zwitterionic sidechains, during channel formation. This approach allows for a continuous modulation of both the electropolymerization onset potential and the native doping state of the film. We attribute the effect of monomer blends displaying properties that are a weighted average of their components to the formation of nanoscale monomer aggregates that have a uniform internal charge density. Through an investigation of monomer aggregation behavior, polymer film growth, and device properties of OECTs fabricated by electropolymerization, we highlight the importance of monomer aggregation in the electropolymerization of conducting polymers. The ability to tune both electropolymerization onset and the OECT threshold voltage has significant implications for the development of more complex circuits for integrated neuromorphic computing, biosensing, and bioelectronic systems.

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Gold nanoparticles modulate the steroidogenic and apoptotic pathway in a buffalo granulosa cell model

Cited by 6 publications

References 32 publications

Nanotechnology for Animal Sciences-New Insights and Pitfalls: A Review

Nanotechnology for Animal Sciences-New Insights and Pitfalls: A Review

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Tuning the Organic Electrochemical Transistor (OECT) Threshold Voltage with Monomer Blends

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