Gold nanoparticles: various methods of synthesis and antibacterial applications

Shah, Monic

doi:10.2741/4284

Cited by 191 publications

(90 citation statements)

References 67 publications

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“…Recent data indicate that nontraditional antimicrobial agents have great promise in the treatment of infectious disease. Specifically, certain classes of nanomaterials, initially proposed as drug carriers in the delivery of chemotherapeutic agents, have been investigated in both in vitro and in vivo settings 13–16 . Metallic nanoparticles such as silver, gold, selenium, and ferrum are characterized by inherent antimicrobial properties 17 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Niemirowicz

Durnaś

Tokajuk

et al. 2017

Sci Rep

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Fungal infections caused by Candida spp. represent an emerging problem during treatment of immunocompromised patients and those hospitalized with serious principal diseases. The ever-growing number of fungal strains exhibiting drug resistance necessitates the development of novel antimicrobial therapies including those based on membrane-permeabilizing agents and nanomaterials as drug carriers. In this study, the fungicidal activities of LL-37 peptide, ceragenin CSA-13 and its magnetic derivatives (MNP@LL-37, MNP@CSA-13) against laboratory and clinical strains of C. albicans, C. glabrata and C. tropicalis were evaluated. These experiments confirm the high anti-fungal activity of these well-characterized agents mediated by their interaction with the fungal membrane and demonstrate elevated activity following immobilization of LL-37 and CSA-13 on the surface of magnetic nanoparticles (MNPs). Furthermore, MNP-based nanosystems are resistant to inhibitory factors present in body fluids and effectively inhibit formation of fungal biofilm. Simultaneously, synthesized nanostructures maintain immunomodulatory properties, described previously for free LL-37 peptide and CSA-13 substrate and they do not interfere with the proliferation and viability of osteoblasts, confirming their high biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Niemirowicz

Durnaś

Tokajuk

et al. 2017

Sci Rep

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“…Thus, AuNPs are likely to be effective anti-tumor drug carriers. The general methods for the synthesis of AuNPs include chemical, physical, and biological methods (Shah et al, 2014). Recently, the so-called green synthesis of AuNPs (involving biological compounds as reducing agents) has been rapidly replacing chemical methods in which toxic chemicals are utilized.…”

Section: Introductionmentioning

confidence: 99%

Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells

Chen

Lee

Huang

et al. 2016

Toxicology and Applied Pharmacology

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“…10 By modulating the synthesis conditions, the size, shape and surface properties of the GNPs can be exquisitely tuned to obtain GNPs with diverse physicochemical, electrical and optical properties. 11 The surface of the GNPs can also be easily tailored to regulate particle stability, solubility and their interaction with the biological environment.…”

Section: Introductionmentioning

confidence: 99%

Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer

et al. 2017

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An astute modification of the plectin-1-targeting peptide KTLLPTP by introducing a C-terminal cysteine preceded by a tyrosine residue imparted a reducing property to the peptide. This novel property is then exploited to fabricate gold nanoparticles (GNP) via an in situ reduction of gold (III) chloride in a one-pot, green synthesis. The modified peptide KTLLPTPYC also acts as a template to generate highly monodispersed, spherical GNPs with a narrow size distribution and improved stability. Plectin-1 is known to be aberrantly expressed in the surface of pancreatic ductal adenocarcinoma (PDAC) cells while showing cytoplasmic expression in normal cells. The synthesized GNPs are thus in situ surface modified with the peptides via the cysteine residue leaving the N-terminal KTLLPTP sequence free for targeting plectin 1. The visual molecular dynamics based simulations support the experimental observations like particle size, gemcitabine conjugation and architecture of the peptide-grafted nanoassembly. Additionally, GNPs conjugated to gemcitabine demonstrate significantly higher cytotoxicity in vitro in two established PDAC cell lines (AsPC-1 and PANC-1) and an admirable in vivo antitumor efficacy in a PANC-1 orthotopic xenograft model through selective uptake in PDAC tumor tissues. Altogether, this strategy represents a unique method for the fabrication of a GNP based targeted drug delivery platform using a multifaceted peptide that acts as reducing agent, template for GNP synthesis and targeting agent to display remarkable selectivity towards PDAC.

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Gold nanoparticles: various methods of synthesis and antibacterial applications

Cited by 191 publications

References 67 publications

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells

Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer

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