Gold nanorods decorated polycaprolactone/cellulose acetate hybrid scaffold for PC12 cells proliferation

Sadraei, Seyed Mahdi; Kiani, Jafar; Ashtari, Behnaz

doi:10.1016/j.ijbiomac.2022.02.156

Cited by 6 publications

(2 citation statements)

References 51 publications

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“…Previous studies suggest metallic nanomaterials can influence the differentiation of mesenchymal stem cells into the cardiac lineage. [55][56][57] Moreover, GNRs may also activate cellular signaling pathways to induce an upregulation of gene expression [58][59][60] that can improve the cardiac maturation. Therefore, the presence of GNR may have multifaceted impacts on the maturation of cardiac tissues.…”

Section: Discussionmentioning

confidence: 99%

Improving the development of human engineered cardiac tissue by gold nanorods embedded extracellular matrix for long-term viability

Sesena-Rubfiaro,

Prajapati,

Lou

et al. 2024

Nanoscale

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Section: Discussionmentioning

confidence: 99%

Improving the development of human engineered cardiac tissue by gold nanorods embedded extracellular matrix for long-term viability

Sesena-Rubfiaro,

Prajapati,

Lou

et al. 2024

Nanoscale

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“…Through variation of the production parameters, properties such as fiber diameter, porosity, and material thickness can be reproducibly tailored to the specific experimental needs [42]. Multifunctional composite materials that consist of different components can be fabricated reliably at the nanometer scale [43][44][45][46]. Because of its many advantages, electrospinning has already been experimentally applied to bone [47,48], cartilage [49,50], tendon/ligament [51,52], skin [53,54], and cardiovascular [55,56] tissue engineering, as well as for wound dressings [57][58][59].…”

Section: Introductionmentioning

confidence: 99%

Novel In Situ-Cross-Linked Electrospun Gelatin/Hydroxyapatite Nonwoven Scaffolds Prove Suitable for Periodontal Tissue Engineering

et al. 2022

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Periodontal diseases affect millions of people worldwide and can result in tooth loss. Regenerative treatment options for clinical use are thus needed. We aimed at developing new nonwoven-based scaffolds for periodontal tissue engineering. Nonwovens of 16% gelatin/5% hydroxyapatite were produced by electrospinning and in situ glyoxal cross-linking. In a subset of scaffolds, additional porosity was incorporated via extractable polyethylene glycol fibers. Cell colonization and penetration by human mesenchymal stem cells (hMSCs), periodontal ligament fibroblasts (PDLFs), or cocultures of both were visualized by scanning electron microscopy and 4′,6-diamidin-2-phenylindole (DAPI) staining. Metabolic activity was assessed via Alamar Blue® staining. Cell type and differentiation were analyzed by immunocytochemical staining of Oct4, osteopontin, and periostin. The electrospun nonwovens were efficiently populated by both hMSCs and PDLFs, while scaffolds with additional porosity harbored significantly more cells. The metabolic activity was higher for cocultures of hMSCs and PDLFs, or for PDLF-seeded scaffolds. Periostin and osteopontin expression was more pronounced in cocultures of hMSCs and PDLFs, whereas Oct4 staining was limited to hMSCs. These novel in situ-cross-linked electrospun nonwoven scaffolds allow for efficient adhesion and survival of hMSCs and PDLFs. Coordinated expression of differentiation markers was observed, which rendered this platform an interesting candidate for periodontal tissue engineering.

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Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

Rahman

Dip

Padhye

et al. 2023

J Biomedical Materials Res

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At present, peripheral nerve injuries (PNIs) are one of the leading causes of substantial impairment around the globe. Complete recovery of nerve function after an injury is challenging. Currently, autologous nerve grafts are being used as a treatment; however, this has several downsides, for example, donor site morbidity, shortage of donor sites, loss of sensation, inflammation, and neuroma development. The most promising alternative is the development of a nerve guide conduit (NGC) to direct the restoration and renewal of neuronal axons from the proximal to the distal end to facilitate nerve regeneration and maximize sensory and functional recovery. Alternatively, the response of nerve cells to electrical stimulation (ES) has a substantial regenerative effect. The incorporation of electrically conductive biomaterials in the fabrication of smart NGCs facilitates the function of ES throughout the active proliferation state. This article overviews the potency of the various categories of electroactive smart biomaterials, including conductive and piezoelectric nanomaterials, piezoelectric polymers, and organic conductive polymers that researchers have employed latterly to fabricate smart NGCs and their potentiality in future clinical application. It also summarizes a comprehensive analysis of the recent research and advancements in the application of ES in the field of NGC.

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Gold nanorods decorated polycaprolactone/cellulose acetate hybrid scaffold for PC12 cells proliferation

Cited by 6 publications

References 51 publications

Improving the development of human engineered cardiac tissue by gold nanorods embedded extracellular matrix for long-term viability

Improving the development of human engineered cardiac tissue by gold nanorods embedded extracellular matrix for long-term viability

Novel In Situ-Cross-Linked Electrospun Gelatin/Hydroxyapatite Nonwoven Scaffolds Prove Suitable for Periodontal Tissue Engineering

Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

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