Gold nanostar‐based complexes applied for cancer theranostics

Yang, Rui; Gao, Yue; Ouyang, Zhijun; Shi, Xiangyang; Shen, Mingwu

doi:10.1002/viw.20200171

Cited by 32 publications

(22 citation statements)

References 114 publications

(209 reference statements)

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“…However, lack of sensibility and susceptible to environmental conditions hampers the universal application of the above electrochemical techniques in clinics. Ratiometric biosensors serve as a practical alternative for detection of multiple biomarkers, due to the ability to amplify the signal changes and eliminate the fluctuations by external factors [38,39,56,57]. In this work, single signal biosensors displayed a maximum DPV response within 30% only (current change of 29.4% for I MB and 20.5% for I Fc , Fig.…”

Section: Construction and Feasibility Verification Of The Biosensormentioning

confidence: 60%

Ratiometric electrochemical OR gate assay for NSCLC-derived exosomes

Meng

Niu

et al. 2023

J Nanobiotechnol

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Non-small cell lung cancer (NSCLC) is the most common pathological type of LC and ranks as the leading cause of cancer deaths. Circulating exosomes have emerged as a valuable biomarker for the diagnosis of NSCLC, while the performance of current electrochemical assays for exosome detection is constrained by unsatisfactory sensitivity and specificity. Here we integrated a ratiometric biosensor with an OR logic gate to form an assay for surface protein profiling of exosomes from clinical serum samples. By using the specific aptamers for recognition of clinically validated biomarkers (EpCAM and CEA), the assay enabled ultrasensitive detection of trace levels of NSCLC-derived exosomes in complex serum samples (15.1 particles μL−1 within a linear range of 102–108 particles μL−1). The assay outperformed the analysis of six serum biomarkers for the accurate diagnosis, staging, and prognosis of NSCLC, displaying a diagnostic sensitivity of 93.3% even at an early stage (Stage I). The assay provides an advanced tool for exosome quantification and facilitates exosome-based liquid biopsies for cancer management in clinics. Graphical Abstract

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Section: Construction and Feasibility Verification Of The Biosensormentioning

confidence: 60%

Ratiometric electrochemical OR gate assay for NSCLC-derived exosomes

Meng

Niu

et al. 2023

J Nanobiotechnol

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“… 93 , 94 . These nanohybrid probes are widely used in theranostics because of easy surface modification, biocompatibility, imaging properties, and exceptional photothermal performance 95 . Such molecular probes also serve as efficient Raman reporters/tags.…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

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Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.

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“…Those nanoparticle-based vehicles can not only improve gene complex stability, drug loading, and drug loading efficiency, but also prevent NA degradation and ensure controlled drug release [ 35 ]. Owing to improved therapeutic efficiency and reduced adverse effects, they are attractive for biomedical delivery and therapy [ 36 , 37 ]. Among them, polycationic nanocarriers are the most popular one.…”

Section: Introductionmentioning

confidence: 99%