Gold nanostars as a colloidal substrate for in-solution SERS measurements using a handheld Raman spectrometer

Mahmoud, Ahmed; Rusin, Casey J.; McDermott, Mark T.

doi:10.1039/c9an02439e

Cited by 33 publications

(35 citation statements)

References 63 publications

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“…(a) Comparison between RSDs from various SERS substrates as reported in literature or presented in this work. Values are collated from the following literature: 3 , [ 31 ] 5 , [ 32 ] 7 , [ 33 ] 8 , [ 34 ] 9 , [ 35 ] 10 , [ 36 ] 11 , [ 37 ] 12 , [ 38 ] 13 , [ 39 ] 14 , [ 40 ] 16 , [ 41 ] 17 , [ 42 ] 18 , [ 43 ] 19 , [ 44 ] 20 , [ 30 ] 21 , [ 32 ] 22 , [ 28 ] 23 , [ 45 ] 24 , [ 46 ] 25 , [ 47 ] 26 , [ 48 ] 27 [ 49 ] , 28 , [ 50 ] 29 , [ 51 ] 30 , [ 52 ] 31 , [ 53 ] 32 , [ 54 ] 33 , [ 55 ] 34 , [ 56 ] 35 , [ 57 ] 36 , [ 58 ] 37 , [ 32 ] 38 , [ 59 ] 39 , [ 29 ] 40 , [ 29 ] 41 , [ 60 ] 42 , [ 61 ] 43 , [ 62 ] 44 , [ 63 ] 45 , [ 64 ] 46 , [ 65 ] 48 , [ 55 ] 49 . [ 33 ] (b) SERS signal for CB[5,7] aggregates for different CB concentrations.…”

Section: Resultsmentioning

confidence: 99%

Eliminating irreproducibility in SERS substrates

Grys

Chikkaraddy

Kamp

et al. 2020

J Raman Spectroscopy

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Irreproducibility in surface-enhanced Raman spectroscopy (SERS) due to variability among substrates is a source of recurrent debate within the field. It is regarded as a major hurdle towards the widespread adoption of SERS as a sensing platform. Most of the literature focused on developing substrates for various applications considers reproducibility of lower importance. Here, we address and analyse the sources of this irreproducibility in order to show how these can be minimised. We apply our findings to a simple substrate demonstrating reproducible SERS measurements with relative standard deviations well below 1% between different batches and days. Identifying the sources of irreproducibility and understanding how to reduce these can aid in the transition of SERS from the lab to real-world applications.

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Section: Resultsmentioning

confidence: 99%

Eliminating irreproducibility in SERS substrates

Grys

Chikkaraddy

Kamp

et al. 2020

J Raman Spectroscopy

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“…However, to create a quantitative method for the selective detection of SARS-CoV-2 from a group of other respiratory viral infections, this method should be the cheapest, simplest, and most reproducible. The reproducibility of SERS sensors can be achieved only in the case of using either nanoperiodic SERS structures obtained using electron lithography methods [41,42] (however, in this case, the cost of their production is high and therefore the method cannot compete with ELISA), or colloidal SERS solutions [23,43]. Colloidal solutions are easy to synthesize, homogeneous, and allow to work on a handheld Raman spectrometer with high laser radiation powers for a long exposure time.…”

Section: Discussionmentioning

confidence: 99%

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

et al. 2021

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During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.

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“…2c) have been shown to generate greater SERS enhancement when excited with NIR lasers. [46][47][48][49][50][51] In order to preserve the intense and distinct Raman fingerprint in the physiological environment, an encapsulating matrix, such as silica or polyethylene glycol (PEG) shell, [52][53][54][55] is often used in order to stabilize the nanomaterial core and protect the Raman reporter molecules against desorption and degradation. To further increase the SERS intensity, the resonant interactions at the metal-reporter interface can be maximized.…”

Section: Principles Of Raman Scattering Surface Enhanced Raman Scattering (Sers) and Surface Enhanced Resonance Raman Scattering (Serrs)mentioning

confidence: 99%

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Kenry¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

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In the last two decades, the application of surface enhanced Raman scattering (SERS) nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman imaging with SERS nanoparticles offers unparalleled sensitivity, providing a platform for molecular targeting, and granting multiplexed and multimodal imaging capabilities. Recent progress has been facilitated not only by the optimization of the SERS contrast agents themselves, but also by the developments in Raman imaging approaches and instrumentation. In this article, we review the principles of Raman scattering and SERS, present advances in Raman instrumentation specific to cancer imaging, and discuss the biological means of ensuring selective in vivo uptake of SERS contrast agents for targeted, multiplexed, and multimodal imaging applications. We offer our perspective on areas that must be addressed in order to facilitate the clinical translation of SERS contrast agents for in vivo imaging in oncology.

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Gold nanostars as a colloidal substrate for in-solution SERS measurements using a handheld Raman spectrometer

Abstract: Colloidal gold nanostars for rapid and in-solution SERS measurements of methimazole in urine using a handheld Raman spectrometer.

Cited by 33 publications

References 63 publications

Eliminating irreproducibility in SERS substrates

Eliminating irreproducibility in SERS substrates

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

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