Gold‐NHC complexes as potent bioactive compounds

Abstract

This report describes the evaluation of the biological activities of 13 gold‐NHC complexes. These complexes were evaluated in vitro for their antioxidant properties, α‐glucosidase, thymidine phosphorylase, β‐glucuronidase and xanthine oxidase enzyme inhibition activities. Among the tested complexes, those bearing chloride ligands were found to be potent antioxidant, α‐glucosidase, thymidine phosphorylase, β‐glucuronidase and xanthine oxidase enzyme inhibitors, showing several hundred fold higher activity than the standard drugs. Some of these complexes were found to be potent antileishmanial agents, which were superior to standard antileishmanil drugs. These gold complexes were also evaluated for their in vitro cytotoxic activity against PC‐3 (normal cells), HeLa (cervical cancer), MCF‐3 (breast cancer) and 3T3 (mouse fibroblast) cell lines.

Silver–N‐Heterocyclic Carbene Complexes: Synthesis, Characterization, and Antimicrobial Properties

“…Most of the biomedical studies on silver–NHC complexes have been conducted with regard to their antimicrobial properties . Although the cytotoxic effects of silver compounds against bacteria have long been established, the mechanisms of action are not completely understood.…”

Optically active histidin-2-ylidene stabilised gold nanoparticles

“…Thus metal-NHC compounds show promise for catalytic applications 14 and also in the biological field. 15,16 For similar reasons, NHCs have attracted much attention in the development of novel nanoparticles [17][18][19][20][21][22][23][24][25][26] as it is estimated that the Au-NHC bond strength is about double that of a corresponding Au-thiol bond, 27 and recent reports show that NHC functionalized AuNPs and gold surfaces outperformed their thiol based counterparts with regards to thermal and chemical stability. 24,27,28 Amongst AuNPs, those with chiral ligands are of particular interest due to their potential applications in optics, asymmetric catalysis and chiral discrimination.…”

Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases

“…In 2016, Al‐Majid et al reported the biological activities of 13 gold‐NHC complexes. Two complexes, [IPrH][Au(Cl) 2 (130) and [IPrH][Au(Cl) 4 (131) , were found to have antioxidant and XO inhibition properties due to ionic nature . Cao et al.…”