Gold sodium thiomalate selectivity inhibits interleukin-5–mediated eosinophil survival

Suzuki, Shuzo; Okubo, Mitsuo; Kaise, Shunji; Ohara, Morihiro; Kasukawa, Reiji

doi:10.1016/s0091-6749(95)70015-3

Cited by 24 publications

(5 citation statements)

References 30 publications

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“…11 These clusters may be responsible for the antiinflammatory activity of nanocrystalline silver. Other noble metals have antiinflammatory activity, [12][13][14][15][16] and in vitro and in vivo studies indicate that when Au 1 is used to treat rheumatoid arthritis, a simultaneous oxidation/reduction reaction produces both Au 31 (which is generally considered to be the active agent) and Au 0.17 . Au 0 nanoparticles have been shown to suppress the activity of IL-6 and TNFa while relieving rheumatoid arthritis symptoms, 17 suggesting that Au 0 may be antiinflammatory rather than Au 31 .…”

Section: Discussionmentioning

confidence: 99%

Does nanocrystalline silver have a transferable effect?

Nadworny¹,

Landry²,

Wang

et al. 2010

Wound Repair and Regeneration

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This study examined the mechanism of nanocrystalline silver antiinflammatory activity, and tested nanocrystalline silver for systemic antiinflammatory effects. Secondary ion mass spectroscopy of skin treated directly with nanocrystalline silver for 24 hours showed that at skin surfaces there were significant deposits at weights corresponding to Ag, AgO, AgCl, AgNO(3), Ag(2)O, and silver clusters Ag(2-6), but silver penetration was minimal. To test for translocation of the effect, a porcine contact dermatitis model in which wounds were induced on one side of the back and then treated with nanocrystalline silver on the opposite side of the back was used. Visual and histological data showed improvement relative to animals treated with saline only. Significantly increased induction of apoptosis in the inflammatory cells present in the dermis was observed with remote nanocrystalline silver treatments. In addition, immunohistochemical analysis showed decreased levels of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-8, and increased levels of antiinflammatory cytokine interleukin-4, epidermal growth factor, keratinocyte growth factor, and keratinocyte growth factor-2. Thus, the antiinflammatory effects of nanocrystalline silver appear to be induced by interactions with cells in the top layers of the skin, which then release biological signals resulting in widespread antiinflammatory activity.

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Section: Discussionmentioning

confidence: 99%

Does nanocrystalline silver have a transferable effect?

Nadworny¹,

Landry²,

Wang

et al. 2010

Wound Repair and Regeneration

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“…Interestingly, this gold compound did not reverse the effects of IL-3 or GM-CSF on eosinophil survival, so its effects seem to be selective towards IL-5 [185].…”

Section: Immunosuppressive Agentsmentioning

confidence: 91%

“…Gold sodium thiomalate, an immunomodulating compound shown to have beneficial effect in the treatment of asthma, has been reported to inhibit IL-5-afforded eosinophil survival [185]. Interestingly, this gold compound did not reverse the effects of IL-3 or GM-CSF on eosinophil survival, so its effects seem to be selective towards IL-5 [185].…”

Section: Immunosuppressive Agentsmentioning

confidence: 99%

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Pharmacological Regulation of Human Eosinophil Apoptosis

Kankaanranta

Moilanen²,

Zhang

2005

CDTIA

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Eosinophilic inflammation of the airways is a key characteristic of asthma. The balance between eosinophil recruitment into the lung and their removal from the lungs determines the number of eosinophils in the airways. Apoptosis or programmed cell death is of importance in the removal of eosinophils from the lungs. In asthma, eosinophil apoptosis is delayed. Glucocorticoids enhance eosinophil apoptosis, whereas beta(2)-agonists may delay apoptosis in eosinophils. Detailed knowledge on the mechanisms that regulate this process gives an opportunity to develop specific asthma therapies targeting the eosinophil. This review aims to focus on the signalling leading to or preventing apoptosis in human eosinophils as well as reviews the current evidence on the regulation of eosinophil apoptosis and/or survival in allergic diseases.

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“…IL-5 is also the most important eosinophil promoter. Suzuki [ 20 ] studies have confirmed that IL-5 inhibits EOS apoptosis. The high-affinity receptors on the EOS membrane combine with IL-5 to transmit the anti-apoptotic information into the cells, inhibit the apoptosis, and maintain the cell survival [ 13 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS

Yan

Bao

et al. 2018

Chin Med

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BackgroundEosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to observe the effect of Chinese medicine Wentong decoction (WTD) in EOS apoptosis in asthmatic rats. This work also explored the mechanism of WTD regulation in EOS apoptosis and provided a new target for clinical treatment of asthma.MethodsAsthmatic rats induced by ovalbumin were treated with WTD. Lung function of rats in each group was detected, and lung tissue pathology, EOS counts in blood and bronchoalveolar lavage fluid were observed. The degree of the EOS apoptosis in rats was detected. The expression content of interleukin (IL)-5, IL-10, chemokine (C–C motif) ligand 5 (CCL5), granulocyte–macrophage colony-stimulating factor (GM-CSF), transforming growth factor beta 1 (TGF-β1), interferon (IFN)-γ, and other cytokines in rat serum and the genes of Eotaxin mRNA, Fas mRNA, FasL mRNA, Fas/FasL and Bcl-2 mRNA in the lung tissues were determined.ResultsWTD can reduced airway resistance in rat models and improved airway compliance. The pathological changes of lung tissue in WTD group were significantly alleviated, at the same time, WTD could reduce the EOS count in the blood and BALF smears of the asthmatic model rats. Compared with the model group, the apoptosis degree of EOS significantly increased in rats in the WTD group. The expression of IL-5, CCL5, and GM-CSF in the serum and the expression of Eotaxin mRNA, Bcl-2 mRNA in the lung tissues in rats in the WTD group rats decreased. Moreover, the expression of IL-10, TGF-β1, and IFN-γ in the serum and the expression of Fas mRNA, FasL mRNA in the lung tissues in rats in the WTD group rats increased compared with that in rats in the model group.ConclusionsWentong decoction may accelerate EOS apoptosis, reduce asthma inflammation, and alleviate the disease through regulating and controlling the factors related to the anti-apoptosis and pro-apoptosis.Electronic supplementary materialThe online version of this article (10.1186/s13020-018-0180-2) contains supplementary material, which is available to authorized users.

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Gold sodium thiomalate selectivity inhibits interleukin-5–mediated eosinophil survival

Cited by 24 publications

References 30 publications

Does nanocrystalline silver have a transferable effect?

Does nanocrystalline silver have a transferable effect?

Pharmacological Regulation of Human Eosinophil Apoptosis

Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS

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