2020
DOI: 10.1016/j.ygcen.2019.113344
|View full text |Cite
|
Sign up to set email alerts
|

Gonadotrope plasticity at cellular, population and structural levels: A comparison between fishes and mammals

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
30
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
2
1

Relationship

3
6

Authors

Journals

citations
Cited by 38 publications
(30 citation statements)
references
References 224 publications
0
30
0
Order By: Relevance
“…Unlike in mammals where the different endocrine cell types are mosaically distributed in the adult anterior pituitary, in teleosts they are spatially discrete through the entire lifespan (6,11). However, in both mammals and teleosts, the anterior pituitary shows high plasticity at both cellular and population levels, allowing the anterior pituitary to meet the demands for hormonal production as they change over the life cycle of an animal (12). At the cellular level, cellular activity (hormone production and release) can be modified by varying regulatory ligand sensitivity through the presence and number of receptors, or by altering rates of hormone synthesis and secretion, the latter corresponding to the hormone release as defined by Jena (13) ( Figure 1A).…”
Section: Introductionmentioning
confidence: 99%
“…Unlike in mammals where the different endocrine cell types are mosaically distributed in the adult anterior pituitary, in teleosts they are spatially discrete through the entire lifespan (6,11). However, in both mammals and teleosts, the anterior pituitary shows high plasticity at both cellular and population levels, allowing the anterior pituitary to meet the demands for hormonal production as they change over the life cycle of an animal (12). At the cellular level, cellular activity (hormone production and release) can be modified by varying regulatory ligand sensitivity through the presence and number of receptors, or by altering rates of hormone synthesis and secretion, the latter corresponding to the hormone release as defined by Jena (13) ( Figure 1A).…”
Section: Introductionmentioning
confidence: 99%
“…The utilization of transgenic animal models has greatly facilitated the study of pituitary function and plasticity. Many diverse, genomic models have been employed in identification of the roles of specific mediators of pituitary physiology and disease through the identification of effects upon whole animal physiology [for review see (2)]. Through the use of genetic models of pituitary cell type-specific leptin receptor knock-out, we have identified the mechanisms by which energy stores, as indicated through serum leptin signaling, influence pituitary function to optimize growth and reproduction.…”
Section: Continuing Discoveries; Mechanisms Mediating Cell Plasticitymentioning
confidence: 99%
“…These opposing challenges of limited cell numbers and diverse, large required outputs are resolved through plasticity in allocation of cell resources to each particular function (see Figure 1). The mechanisms controlling pituitary cell plasticity are a source of tremendous interest since these mechanisms first began to be revealed and evidence of malfunction in pituitary plasticity under diverse genetic and disease states has further motivated study to understand these mechanisms [for reviews see (1,2)]. Over the last several decades, an ongoing procession of cutting edge, novel techniques have been developed and embraced in the effort to understand pituitary function and plasticity.…”
Section: Introductionmentioning
confidence: 99%
“…Fsh and Lh are heterodimeric glycoproteins consisting of two non-covalently linked subunits, a common α-(Gpα), and a hormone-specific β-subunit (Lhβ or Fshβ) that confers the biological activity (Pierce and Parsons, 1981; Swanson et al, 2003). Unlike mammals, where both gonadotropins are produced from the same pituitary cell, Fsh and Lh in teleosts are mostly produced from two different cell types, located in the proximal pars distalis (PPD) of the pituitary gland (Fontaine et al, 2020a; Levavi-Sivan et al, 2010; Weltzien et al, 2004).…”
Section: Introductionmentioning
confidence: 99%