Gone with the Wind - Innate Immunity and Airway Inflammation

Herwald, Heiko; Egesten, Arne

doi:10.1159/000444614

Cited by 1 publication

(1 citation statement)

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“…Innate immune cells are known to play an important role in airway allergic inflammation 6 . When stimulated by allergens, lung epithelial cells can produce multiple cytokines, including thymic stromal lymphopoietin (TSLP) and IL-33 7 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells

Wang

Lin

Zeng

et al. 2017

Sci Rep

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Airway epithelial cell-derived thymic stromal lymphopoietin (TSLP) and IL-33 can enhance lung-resident group 2 innate lymphoid cells (ILC2s), and they play an important role in the development of allergic diseases. This study tests the hypothesis that Der f 31 (Dermatophagoides farinae-31), an allergen, modulates airway epithelial cell functions and increases the frequency of lung ILC2s. Our previous research identified cofilin (Der f 31) as a novel allergen. In this study, we found that recombinant Der f 31 (r-Der f 31) upregulated the expression of co-stimulatory molecules in DCs and promoted Th2-skewed polarization. The levels of TSLP and IL-33 in epithelial cells were upregulated by r-Der f 31 via the activation of Toll-like receptor 2. Furthermore, in in vivo studies, r-Der f 31 induced eosinophil-like airway allergy and increased the number of lung-resident ILC2s. In summary, Der f 31 can modulate the functions of airway epithelial cells and increase levels of lung-resident ILC2s.

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Section: Introductionmentioning

confidence: 99%