2023
DOI: 10.1093/humrep/dead184
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Good practice recommendations on add-ons in reproductive medicine

K Lundin,
J G Bentzen,
G Bozdag
et al.

Abstract: STUDY QUESTION Which add-ons are safe and effective to be used in ART treatment? SUMMARY ANSWER Forty-two recommendations were formulated on the use of add-ons in the diagnosis of fertility problems, the IVF laboratory and clinical management of IVF treatment. WHAT IS KNOWN ALREADY The innovative nature of ART combined with the extremely high motivation of th… Show more

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Cited by 49 publications
(4 citation statements)
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“…In subgroup analysis, calcium ionophore positive effect was mainly in patients with previous low fertilization, fertilization failure, and cleavage problems. ESHRE Recommended that artificial oocyte activation using Ca 2+ -ionophores is mainly recommended for cases of complete activation failure (0% 2PN), and very low fertilization (17). In the current preliminary report, such a positive effect was also obtained in couples without a history of impaired fertilization.…”
Section: Resultsmentioning
confidence: 58%
See 1 more Smart Citation
“…In subgroup analysis, calcium ionophore positive effect was mainly in patients with previous low fertilization, fertilization failure, and cleavage problems. ESHRE Recommended that artificial oocyte activation using Ca 2+ -ionophores is mainly recommended for cases of complete activation failure (0% 2PN), and very low fertilization (17). In the current preliminary report, such a positive effect was also obtained in couples without a history of impaired fertilization.…”
Section: Resultsmentioning
confidence: 58%
“…Calcium surge resulting in artificial oocyte activation (AOA) can be induced from two potential Ca 2+ sources: internal calcium storages and/or external culture medium (17).…”
Section: Introductionmentioning
confidence: 99%
“…In clinical settings, the strategic timing and precise dosage of intrauterine hCG perfusion are crucial for enhancing implantation success, particularly in patients with a history of RIF. Although some studies recognize the benefits of hCG perfusion, significant debate persists over the optimal timing and dosage [ 61 ]. Research and current guidelines suggest that administering hCG shortly before embryo transfer can significantly improve outcomes by ensuring higher concentrations of hCG are present at the site of action [ 62 ], potentially overcoming barriers related to suboptimal endogenous LH activity or inadequate endometrial responsiveness.…”
Section: Discussionmentioning
confidence: 99%
“…The dosage of intrauterine hCG perfusion in IVF treatments lacks standardization, with effectiveness proving to be dosage-dependent [ 61 ]. Studies show that lower dosages, less than 500 IU, typically do not enhance live birth rates, whereas higher dosages of 500 IU or more may improve outcomes [ 63 ].…”
Section: Discussionmentioning
confidence: 99%