Gotu Kola (Centella asiatica)

Belwal, Tarun; Andola, Harish Chandra; Atanassova, Maria; Joshi, Bhasker; Suyal, Renu; Thakur, Shinny; Bisht, Arti; Jantwal, Arvind; Bhatt, Indra D.; Rawal, Ranbeer S.

doi:10.1016/b978-0-12-812491-8.00038-2

Cited by 19 publications

(9 citation statements)

References 44 publications

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“…The whole plant of C. asiatica including leaves, stem, and roots is consumed fresh as a salad in Southeast Asia (Hashim et al, 2011). Previous study has demonstrated that the anti‐inflammatory effect of C. asiatica against gastrointestinal disorder, asthma, and wound healing was mainly attributed to terpenoids and flavonoids in the leaves (Belwal et al., 2019). The flower of M. acuminata has been a part of the traditional medicines for various communicable and non‐communicable diseases in Oceania, Africa, Asia, and India (Sumathy, Lachumy, Zakaria, & Sasidharan, 2011).…”

Section: Introductionmentioning

confidence: 99%

The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

Samsuri

Yong

2020

J Food Process Preserv

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This study aimed to evaluate the effect of four solvents (water, methanol, ethyl acetate, and n‐hexane) on the extraction of total phenolic content (TPC), tannin, flavonoid, ferric reducing power (FRAP), and radical scavenging activity from Centella asiatica, Musa acuminata, Peperomia pellucida, and Psophocarpus tetragonolobus. The extraction of TPC, tannin, flavonoid, and antioxidant activity varied significantly according to solvent polarity and plant species. The strong linear correlation found between solvent polarity index and TPC, tannin, FRAP as well as radical scavenging activity indicated solvents with increasing polarity favored the extraction of phenolic antioxidants. Plant species and extraction solvents contributed to 51.7% and 21.8% of total activity variation, respectively. C. asiatica, M. acuminata flower, and P. pellucida were best extracted with 80°C distilled water for a short duration, while methanol was preferred for P. tetragonolobus. The antioxidant index could be a potential ranking tool to identify the ideal extraction solvent for medicinal plants. Practical applications Considering the high commercial and health‐oriented values of natural phenolic antioxidants such as tannin and flavonoid, efficient extraction of these phytochemicals from different plant sources remains a challenging task due to their varying physicochemical characteristics and solubility. This study has addressed that the choice of solvents and types of plant species are critical extraction parameters for natural plant products. Comparison of tannin and flavonoid content among the different solvent extracts could reveal the ideal solvent which maximizes the extraction of phenolic antioxidants from different medicinal plants. The finding in this study may inspire nutraceutical, pharmaceutical, and cosmetic industries to re‐evaluate their procedure in selecting the optimal extraction solvent and condition for different plant materials. The proposed antioxidant index in this study could serve as a potential tool to rank extraction solvents based on the antioxidant values extracted from different medicinal plants.

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Section: Introductionmentioning

confidence: 99%

The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

Samsuri

Yong

2020

J Food Process Preserv

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“…Khasiat secara ilmiah dari C. asiatica telah banyak diteliti pada hewan coba dan menyimpulkan bahwa C. asiatica dapat digunakan sebagai antioksidan, antigastritis, antitumor, penyembuhan luka, imunomodulator, antiproliferasi, dan sebagainya. [9][10][11][12][13][14][15][16] Selain itu, dalam hasil Saintifikasi Jamu disimpulkan bahwa C. asiatica merupakan salah satu komponen ramuan antihipertensi. 17,18 Dalam usaha Saintifikasi Jamu dan menjaga kualitas bahan baku tumbuhan obat yang mengandung C. asiatica, ada beberapa tahapan yang harus dilakukan, salah satu yang terpenting adalah autentikasi dari bahan baku tumbuhan obat, secara makroskopis, mikroskopis, dan profil kimia.…”

Section: Pendahuluanunclassified

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia

Maruzy

Budiarti

Subositi

2020

jki

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Pegagan or Centella asiatica (L.) Urb. empirically used as medicinal plant and scientifically can be used as antihypertension based on the results of the Jamu Saintification. Raw materials from C. asiatica have the potential to occur adulteration or incorrect use of plants species. There are two species of plants that have the potential to become adulterants of C. asiatica, namely Hydrocotyle verticillata and Merremia emarginata. Thus, the purpose of this study is to authenticate from Pegagan by comparing the macroscopic, microscopic, and chemical profiles of C. asiatica, H. verticillata, and M. emarginata. The method of data collection is done by purposive sampling using form intruments to record macroscopic and microscopic characters, while the chemical profiles are tested using thin layer chromatography methods to determine the content of asiaticosides in both potential adulterants species. The research was conducted at three sampling points: Central Java (Tawangmangu), West Java (Bogor), and East Java (Malang), while for laboratory research activities carried out at B2P2TOOT, Tawangmangu. The results showed macroscopically unique and easy distinguishing characters between C. asiatica and potential adulterant species H. verticillata is a leaf shape, whereas C. asiatica with M. emarginata are leaf-type appearance characters. The character of the simplicia leaf shape between C. asiatica and H. verticillata can be a distinct differentiator characters. Anatomical characters and powder fragments that can be used as a differentiator characters between C. asiatica and H. verticillata are the presence of pith on the stalk and stolon, the type of stomata, and the presence of trichomes. Authentication of simplicia powder of H. verticillata as an adulterant potential of C. asiatica with TLC, can be easily known by the absence of asiaticosides in these simplicia so that H. verticillata cannot be a substitute species for C. asiatica

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“…Centella asiatica (L.) Urban (Apiaceae), commonly known as Gotu Kola, is a perennial plant growing in tropical and subtropical swampy regions of Asia, Africa, South and North America . It has been widely used since ancient times in many traditional medicinal systems such as Ayurveda or traditional Chinese medicine.…”

Section: Introductionmentioning

confidence: 99%

“…It is also recommended in skin regeneration and wound healing treatment. C. asiatica extract influence collagen synthesis so it is used not only in medicine but also in cosmetology .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elicitation with methyl jasmonate combined with cultivation in the Plantform™ temporary immersion bioreactor highly increases the accumulation of selected centellosides and phenolics in Centella asiatica (L.) Urban shoot culture

Skrzypczak-Pietraszek

Urbańska

Żmudzki

et al. 2019

Engineering in Life Sciences

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Centella asiatica (L.) Urban is an important pharmacopoeial plant used not only in medicine but also in cosmetology. C. asiatica agitated shoot cultures were established to study the influence of ethephon, methyl jasmonate, L‐phenylalanine (Eth 50 µM, MeJa 50 µM, L‐Phe 2.4 g/L of medium, respectively; seven variants of the supplementation) on the accumulation of secondary metabolites: the main centellosides (asiaticoside and madecassoside) and selected phenolic acids, and flavonoids in the biomass. Microshoots were harvested two and six days after the supplementation. Secondary metabolites were analyzed in methanolic extracts by UPLC‐MS/MS (centellosides) and by HPLC‐DAD (phenolics). In comparison with the reference cultures, the concentrations of individual secondary metabolites increased as follows: centellosides up to 5.6‐fold (asiaticoside), phenolic acids up to 122‐fold (p‐coumaric acid) and flavonoids up to 22.4‐fold (kaempherol). The highest production increase of individual compounds was observed for different variants of supplementation. Variant C (50 µM MeJa), the most optimal for centellosides and flavonoid accumulation, was selected for the experiment with bioreactors. Bioreactor Plantform™, compared to RITA® system and agitated cultures, appeared to be the most advantageous for secondary metabolites production in C. asiatica shoot cultures. The phenolic acid, flavonoid, centelloside, and total secondary metabolite productivity in Plantform™ system is 1.8‐fold, 1.7‐fold, 2.8‐fold, 2.1‐fold, respectively, higher than in MeJa elicitated agitated cultures, and 4.3‐fold, 7.3‐fold, 12.2‐fold, 7.2‐fold, respectively, higher than in control agitated cultures.

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Gotu Kola (Centella asiatica)

Cited by 19 publications

References 44 publications

The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia

Elicitation with methyl jasmonate combined with cultivation in the Plantform™ temporary immersion bioreactor highly increases the accumulation of selected centellosides and phenolics in Centella asiatica (L.) Urban shoot culture

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