Gout and hyperuricaemia

Abrahams, Mogamat Nur

doi:10.7196/samj.2015.v105i12.10225

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Gout, a common chronic disease that usually manifests as acute or chronic joint inflammation, is a type of inflammatory arthritis caused by increased urate concentrations and the deposition of monosodium urate (MSU) crystals (Harris et al, 1999 ; Abrahams, 2015 ; Dalbeth et al, 2021 ). Gout and hyperuricemia result in metabolic comorbidities, such as hypertension, hyperlipidemia, atherosclerosis, nephropathy, and obesity (Dalbeth et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

Liu

Zhu

et al. 2022

Drug Delivery

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Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col via the transdermal route. We studied the preparation, mechanical properties, skin insertion, skin irritation, drug content, and transdermal release of the Col-loaded MN. The pharmacokinetics of Col after Col-loaded MN application were compared with those of Col solution gavage over 24 h. Knee joint edema evaluation and the hindfoot mechanical threshold test were conducted to determine the pharmacodynamic profile. The dissolvable Col-loaded MN possessed sufficient mechanical strength to penetrate the skin and release the loaded drug. No skin irritation was observed for 3 days after application. We found that 3.36-fold more Col contained in MNs was delivered through the skin compared with that in gel in vitro , and moderate relative bioavailability in vivo . The Col-loaded MN significantly relieved swollen knee joints and mechanical hypernociception in an acute gout model in rats. The dissolvable Col-loaded MN array reduced inflammation and pain via topical administration when acute gout occurred. Reducing the gastrointestinal side effects of Col-loaded MNs is expected to optimize the therapeutic effects of Col and improve patient compliance.

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Section: Introductionmentioning

confidence: 99%

Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

Liu

Zhu

et al. 2022

Drug Delivery

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“…Cervical cancer (CaCx) is the 9 th most severe cancer in the world with 3.4 lakh deaths and >6.0 lakh new cases worldwide and ranks 4 th among women in 2020 [1]. In India, it ranks 2 nd with >1.2 lakh new cases and >77,000 deaths [1]. The main causing agent of cervical cancer is human papillomavirus (HPV).…”

Section: Introductionmentioning

confidence: 99%

Anthro-demographic, clinico-pathological and biochemical risk factors in cervical cancer

Kushwah

Mishra

Srivastava

et al. 2022

ijhs

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Background: In India, cervical cancer (CaCx) ranks second with >1.2 lakh new cases and >77,000 deaths. The main causing agent of cervical cancer is human papillomavirus (HPV). Recently, anthro-demographic and clinico-pathological factors have been implicative of cancer development and progression. Objective: To evaluate the association of anthro-demographic, clinico-pathological and biochemical risk factors in cervical cancer. Methods: CaCx patients were tested for HPV infection using conventional PCR. Anthro-demographic and clinico-pathological characteristics were recorded and samples from patients (n=103) and healthy women (n=108) were analyzed for lipid profile, serum urea, creatinine and uric acid using commercial kits. Statistical analysis was done using SPSS (ver.21.0) and GraphPad. Results: Out of 103 CaCx patients, 86 were HPV+ve and 17 HPV-ve. Anthro-demographic factors like literacy, socio-economic status and obstetrics were found significantly associated with cervical cancer. BMI was associated with cervical cancer (1.18 folds higher risk). Total cholesterol (TC); triglycerides (TG); high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were found significantly associated with an increased adjusted OR in CaCx patients. Urea levels were found significantly higher in patients (1.11 folds crude OR vs 1.31 adjusted OR). Similarly, creatinine levels were significantly higher in patients (2.64 folds crude OR vs 3.37 adjusted OR).

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“…Pathways involved in metabolism can be targeted for therapeutic purposes. Hyperuricemia is caused by abnormal metabolism of uric acid, which has been demonstrated to be involved in the pathogenesis of gout, cardiovascular diseases, respiratory diseases and tumors [4,[6][7][8]. Although serum uric acid possesses antioxidant properties, increased levels of serum uric acid can lead to local or systematic inflammatory response in human body and thus promote the occurrence of tumors.…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia predicts poor prognosis of patients with cervical cancer

Li¹,

Li²,

Su³

et al. 2018

Oncotarget

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Previous studies have suggested that hyperuricemia plays an important role in cancer initiation and progression; however, little is known about the role of hyperuricemia in the prognosis of cervical cancer. The aim of this study was to evaluate the association between hyperuricemia and cervical cancer by conducting a retrospective cohort study. 50 cervical cancer patients with hyperuricemia were randomly selected and 1:1 age-matched to 50 normouricemia patients with cervical cancer. We used the Kaplan-Meier survival analysis to determine the overall survival of patients with cervical cancer. Cox regression analysis was also adopted to estimate the role of hyperuricemia in cervical cancer prognosis primarily adjusted by age, tumor stage, status of histological grade, lymph node involvement, and histopathological subtype. The Kaplan-Meier analysis showed patients with hyperuricemia had poorer overall survival than those with normouricemia (P = 0.0086). The univariate and multivariate Cox analyses both showed that hyperuricemia was negatively associated with the overall survival of patients with cervical cancer. Our study suggests that hyperuricemia is related to poor prognosis of patients with cervical cancer.

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Gout and hyperuricaemia

Cited by 7 publications

References 6 publications

Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

Anthro-demographic, clinico-pathological and biochemical risk factors in cervical cancer

Hyperuricemia predicts poor prognosis of patients with cervical cancer

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