GPX1 Localizes to the Nucleus in Prostate Epithelium and its Levels are not Associated with Prostate Cancer Recurrence

Ekoue, Dede N.; Ansong, Emmanuel; Hong, Lenny; Nonn, Larisa; Macias, Virgilia; Deaton, Ryan; Rupnow, Rawan Allozi; Gann, Peter H.; Kajdacsy-Balla, André; Diamond, Alan M.

doi:10.3390/antiox7110167

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…GPX1 expression was not associated with the radiotherapy response nor survival in head and neck cancer (21). Moreover, the expression level of GPX1 was not associated with prostate cancer recurrence (21,22).…”

Section: Discussionmentioning

confidence: 96%

Expression and prognostic potential of GPX1 in human cancers based on data mining

Wei¹,

Qiu²,

Xu³

et al. 2020

Ann Transl Med

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Background: Glutathione peroxidase-1 (GPX1) is a member of the GPX family, which considered an enzyme that interacts with oxidative stress. GPX1 differential expression is closely correlated with carcinogenesis and disease progression. In this study, we used bioinformatics analysis to investigate GPX1 expression level and explore the prognostic information in different human cancers. Methods: Expression was analyzed via the Oncomine database and Gene Expression Profiling InteractiveAnalysis tool, and potential prognostic analysis was evaluated using the UALCAN, GEPIA, and DriverDBv3 databases. Then, the UALCAN database was used to find the promoter methylation of GPX1 in defied cancer types. While GPX1 related functional networks were found within the GeneMANIA interactive tool and Cytoscape software. Moreover, Metascape online website was used to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways.Results: We found that GPX1 was commonly overexpressed in most human cancers. High expression of GPX1 could lead to poor outcomes in Brain Lower Grade Glioma, while GPX1 over expression was correlated with better prognosis in Kidney renal papillary cell carcinoma (KIPP). High GPX1 expression was marginally associated with poor prognosis in acute myeloid leukemia (AML). Gene regulation network suggested that GPX1 mainly involved in pathways including the glutathione metabolism, ferroptosis, TP53 regulates metabolic genes, reactive oxygen species (ROS) metabolic process, and several other signaling pathways.Conclusions: Our findings revealed that GPX1 showed significant expression differences among cancers and served as a prognostic biomarker for defined cancer types. The data mining effectively revealed useful information about GPX1 expression, prognostic values, and potential functional networks in cancers, thus providing researchers with an available way to further explore the mechanism underlying carcinogenesis of genes of interest in different cancers.

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Section: Discussionmentioning

confidence: 96%

Expression and prognostic potential of GPX1 in human cancers based on data mining

Wei¹,

Qiu²,

Xu³

et al. 2020

Ann Transl Med

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show abstract

“…Lee et al reported in their series of patients with oral squamous cell carcinoma that high GPX1 levels were associated with short overall survival [ 12 ]. On the contrary, Ekoue et al published that GPX1 expression levels have no impact on survival in patients with prostatic adenocarcinoma [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma

et al. 2021

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Malignant pleural mesothelioma (MPM) is a malignant tumor of the mesothelial lining of the thorax. It has been related to frequent exposure to asbestos. Diagnosis of malignant pleural mesothelioma is considered a criticizing problem for clinicians. Early diagnosis and sufficient surgical excision of MPM are considered the cornerstone success factors for the management of early MPM. Glutathione peroxidase-1 (GPX1) is an intracellular protein found to be extensively distributed in all cells, and it belongs to the GPX group. In the current study, we included ninety-eight patients with MPM that underwent surgery at the Zagazig University Hospital in Egypt. We assessed GPX1 gene expression level as it was thought to be related to pathogenicity of cancer in a variety of malignant tumors. We observed a significant elevation in GPX1-mRNA levels in MPM relative to the nearby normal pleural tissues. It was found to be of important diagnostic specificity in the differentiation of MPM from normal tissues. Moreover, we studied the survival of patients in correlation to the GPX1 expression levels and we reported that median overall survival was about 16 months in patients with high GPX1 expression levels, while it was found to be about 40 months in low GPX1 levels.

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Selenoproteins of the Human Prostate: Unusual Properties and Role in Cancer Etiology

Diamond

2019

Biol Trace Elem Res

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GPX1 Localizes to the Nucleus in Prostate Epithelium and its Levels are not Associated with Prostate Cancer Recurrence

Cited by 5 publications

References 32 publications

Expression and prognostic potential of GPX1 in human cancers based on data mining

Expression and prognostic potential of GPX1 in human cancers based on data mining

Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma

Selenoproteins of the Human Prostate: Unusual Properties and Role in Cancer Etiology

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