Graft-versus-host disease management

Mistrík, Martin; Bojtárová, Eva; Sopko, L; Masakova, L; Roziakova, Lubica; Martinka, J.; Bátorová, Angelika

doi:10.4149/bll_2016_077

Cited by 6 publications

(6 citation statements)

References 42 publications

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“…In the meantime, verification of clinical protocols dedicated to the transplantation programme was conducted. A preliminary list of nursing protocols has been developed: Oral care[11]CVC management–no-touch technique[12]Food and diet around HSCTChemotherapy extravasation: prevention, management and treatmentPain management[13, 14]Isolation rules[15]GVHD management[16, 17]…”

Section: Resultsmentioning

confidence: 99%

The first hematopoietic stem cell transplantation centre in Iraqi Kurdistan: nursing perspectives and education

Canesi¹,

Broggi²,

Fazil³

et al. 2019

ecancer

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Aim To describe the nursing capacity-building process within the foundation of a hematopoietic stem cell transplantation (HSCT) centre at the Hiwa Cancer Hospital (HCH), Sulaymaniyah, Iraqi Kurdistan, referring to nursing education, empowerment and leadership. Methods 1) Capacity building, the process by which individuals, organisations, institutions and societies develop abilities to perform functions, solve problems and set and achieve objectives, was implemented; 2) Nurse intervention was based exclusively on training and coaching on site, which is an innovative approach, since more often experts are brought to the centre to train people on site; 3) Nurses’ personal skills, knowledge and training needs in the field at the HSCT centre were preliminarily explored through an online survey, and intervention was also addressed considering personal preferences and challenges; 4) Clinical documentation implementation and nursing professional organisation improvements were developed. Results/findings 1) up to June 2018, 98 patients have been transplanted (69 autologous + 29 allogeneic graft). The centre at the HCH represents the first in Kurdistan and the only centre carrying out allogeneic transplants in the whole of Iraq; 2) twenty-two staff nurses; three nurses in charge and one head nurse are employed in the HSCT centre. Nurses currently have good capability to manage daily care for patients in the HSCT centre. There are still training needs to be addressed; 3) and 4) implementation of organigram, job description and nursing plans. The situation, background, assessment, recommendation method for nursing handover was introduced. Nursing shifts duration was changed. Conclusion/implications for nursing Capacity building cooperation is a powerful means to successfully establish a high technology medical programme, and is a feasible method to enhance skills and expertise even in low resources contexts. The programme is still in progress and consolidating actions are still required. Nurses need to enforce professional leadership and work organisation. The HSCT centre local team needs to improve teamwork and shared decision making.

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Section: Resultsmentioning

confidence: 99%

The first hematopoietic stem cell transplantation centre in Iraqi Kurdistan: nursing perspectives and education

Canesi¹,

Broggi²,

Fazil³

et al. 2019

ecancer

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“…Similar findings were noted by them, where they found that combining the marker and covariate information can improve sensitivity, specificity, and AUC as well as improve the diagnostic performance 26,27 . More importantly, several factors have been introduced as GVHD risk factors of which the patients age is considered to have an influencing role in GVHD 28 . Further, according to the literature review, a number of studies have been demonstrated that gender disparity influence the GVHD incidence.…”

Section: Discussionmentioning

confidence: 99%

Application of latent class analysis in diagnosis of graft-versus-host disease by serum markers after allogeneic haematopoietic stem cell transplantation

Amini

Kazemnejad

Rasekhi

et al. 2020

Sci Rep

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2 for a composite test is as the same as a diagnostic test. For choosing optimal cutoff point, the Youden index which mentioned before, was used for the combinations. Afterward, the cSensitivity and cSpecificity were selected. For the models, the convergence of the MCMC chains for all the LCMs (with and without covariate adjustment) was assessed using autocorrelation plots. Furthermore, the convergence was obtained by running one chain with 35,000 iterations with lag 45. The first 17,000 iterations were discarded. The Bayesian latent class models were fitted by using OpenBUGS 3.2.1 41. The R package R2OpenBUGS 42 also applied as an interface between R 3.6.2 43 and OpenBUGS. After determining the GVHD groups based on optimal composite test, in order to evaluate the association between each of continuous variables and GVHD, an independent sample t-test was performed and chi-square test was applied for each categorical variable. All comparisons were two-tailed and p-value of less than 0.05 was taken as statistically significant. Descriptive analyses were performed using R version 3.6.2.

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“…Imatinib disrupts these pathways, and its use in the management of treatment-resistant GvHD has been found to be effective 9. It is used most frequently when there is a sclerotic dermal involvement of chronic GvHD and has been found to be very effective in such cases 10…”

Section: Discussionmentioning

confidence: 99%

Imatinib-induced pericardial effusion in a child

Terry

Avery²,

Morton

et al. 2019

BMJ Case Rep

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A 12-year-old boy presented with central chest pain, shortness of breath and type 1 respiratory failure. He had a background of graft versus host disease (GvHD), which was currently managed with imatinib therapy. A focused bedside ultrasound scan was performed revealing a large pericardial effusion. The child was referred to a tertiary paediatric cardiology centre where he underwent emergency pericardiocentesis, draining a total of 800 mL of pericardial fluid. Fluid analysis excluded infection, and with no other concerns for a GvHD flare the diagnosis of an imatinib-induced pericardial effusion was made. On terminating the therapy, the pericardial collection did not reaccumulate. Tyrosine kinase inhibitor-induced pericardial and/or pleural effusion should be considered as a differential diagnosis in paediatric patients on this therapy presenting in a similar manner.

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Graft-versus-host disease management

Cited by 6 publications

References 42 publications

The first hematopoietic stem cell transplantation centre in Iraqi Kurdistan: nursing perspectives and education

The first hematopoietic stem cell transplantation centre in Iraqi Kurdistan: nursing perspectives and education

Application of latent class analysis in diagnosis of graft-versus-host disease by serum markers after allogeneic haematopoietic stem cell transplantation

Imatinib-induced pericardial effusion in a child

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