Gram-negative hospital pathogens at risk of severe bacterial infection

Abstract

Background. Nosocomial infections remain an urgent problem of modern medicine. Along with bacterial infection of the bloodstream a special danger is posed by ventilation-dependent lung infection (VDLI), the main source which are still at the intensive care unit (ICU).Objectives. Assessment of the spread of bacterial infections in ICU over a five-year period. Analysis of the severity of postoperative complications depending on the infection location.Methods. A retrospective analysis of the frequency and form of blood flow and ventilation-dependent lung infection in patients, operated under cardiopulmonary bypass in the years 2013–2017.Results. The rate of blood contamination in the departments ranged from 8.0 to 9.8 %; against the ICU — from 17 to 24 % (p < 0,01). Gram-negative associated mortality was significantly higher than gram-positive (p < 0.001). Acinetobacter spp. and Klebsiella spp. are the most common agents. Analysis of the primary detection of the pathogen showed that in 73.6 % of cases, the trachea is the area of the initial localization of combined-form infection.Conclusions. The risk of bacterial complications in the early postoperative period is associated with gram-negative pathogen s (Acinetobacter spp. and Klebsiella spp.). Constant bacteriological monitoring in ICU is an effective prognostic tool of blood flow and ventilation-dependent lung infection.

The problem of global development of antibiotic resistant nosocomial pathogens

“…Шумакова», в период с 2009 по 2019 г. включительно. Всего обследованы 4665 пациентов в соответствии со стандартной методикой бактериологических исследований [11,15]. Показано, что к 2019 г. для реципиентов донорских органов инфицированность крови как грамотрицательными, так и грамположительными возбудителями приобретает более тяжелый характер, отражаемый в виде динамики роста летальности (с 39,7 до 52,1% и с 13,6 до 22,2% соответственно; табл.…”