Grand Challenges in Microalgae Domestication

Maréchal, Éric

doi:10.3389/fpls.2021.764573

Cited by 7 publications

(5 citation statements)

References 62 publications

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“…The optimization of cultivation, harvesting, extraction, and downstream processing costs will all be required to ensure the competitiveness of these products against traditional sources. Although microalgae offer great genetic diversity, there is still a significant deficit in the number of sequenced genomes and the number of microalgae that have been genetically transformed in the lab ( Lin et al, 2019 ; Maréchal, 2021 ). The full potential of microalgae is still largely unrealized due to our limited understanding of their metabolic pathways, regulatory networks, and genetic makeup ( Kumar et al, 2020 ).…”

Section: Microalgae For Sustainable Bioeconomymentioning

confidence: 99%

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Harnessing genetic engineering to drive economic bioproduct production in algae

Gupta,

Kang,

Pathania

et al. 2024

Front. Bioeng. Biotechnol.

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Our reliance on agriculture for sustenance, healthcare, and resources has been essential since the dawn of civilization. However, traditional agricultural practices are no longer adequate to meet the demands of a burgeoning population amidst climate-driven agricultural challenges. Microalgae emerge as a beacon of hope, offering a sustainable and renewable source of food, animal feed, and energy. Their rapid growth rates, adaptability to non-arable land and non-potable water, and diverse bioproduct range, encompassing biofuels and nutraceuticals, position them as a cornerstone of future resource management. Furthermore, microalgae’s ability to capture carbon aligns with environmental conservation goals. While microalgae offers significant benefits, obstacles in cost-effective biomass production persist, which curtails broader application. This review examines microalgae compared to other host platforms, highlighting current innovative approaches aimed at overcoming existing barriers. These approaches include a range of techniques, from gene editing, synthetic promoters, and mutagenesis to selective breeding and metabolic engineering through transcription factors.

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Section: Microalgae For Sustainable Bioeconomymentioning

confidence: 99%

“…Frontiers in Bioengineering and Biotechnology frontiersin.org Maréchal, 2021). The full potential of microalgae is still largely unrealized due to our limited understanding of their metabolic pathways, regulatory networks, and genetic makeup (Kumar et al, 2020).…”

Section: Microalgae As a Platform For Sustainable Bioeconomy: Potenti...mentioning

confidence: 99%

Harnessing genetic engineering to drive economic bioproduct production in algae

Gupta,

Kang,

Pathania

et al. 2024

Front. Bioeng. Biotechnol.

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“…Domestication of new plant species in the twenty-first century has been initiated despite resource constraints, and these efforts span plant families and types: bioenergy crops ( 150 ), cacti ( 151 ), ferns ( 152 ), halophytes ( 153 – 160 ), tree fruits and nuts ( 161 , 162 ), macroalgae ( 163 – 166 ), marine grasses ( 141 , 167 ), microalgae ( 168 ), palms ( 169 , 170 ), perennial grasses ( 171 – 173 ), perennial groundcovers ( 174 ), perennial oilseeds ( 90 , 175 , 176 ), and perennial tree and grain legumes ( 177 – 179 ).…”

Section: How Can Domestication Increase Diversity To Enable Agricultu...mentioning

confidence: 99%

The next era of crop domestication starts now

Krug

Drummond

Tassel

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Current food systems are challenged by relying on a few input-intensive, staple crops. The prioritization of yield and the loss of diversity during the recent history of domestication has created contemporary crops and cropping systems that are ecologically unsustainable, vulnerable to climate change, nutrient poor, and socially inequitable. For decades, scientists have proposed diversity as a solution to address these challenges to global food security. Here, we outline the possibilities for a new era of crop domestication, focused on broadening the palette of crop diversity, that engages and benefits the three elements of domestication: crops, ecosystems, and humans. We explore how the suite of tools and technologies at hand can be applied to renew diversity in existing crops, improve underutilized crops, and domesticate new crops to bolster genetic, agroecosystem, and food system diversity. Implementing the new era of domestication requires that researchers, funders, and policymakers boldly invest in basic and translational research. Humans need more diverse food systems in the Anthropocene—the process of domestication can help build them.

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“…Chlorella are maintained in haploid form and produce asexually reproducing autospores by mitosis [ 19 , 20 ]. Reproduction typically involves the production of four daughter cells within a mother cell, and when these daughter cells become mature, the cell wall of the mother cell ruptures to enable the daughter cells to divide and emerge [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Calcium Depletion on Proliferation of Chlorella sorokiniana Strain DSCG150

Kang,

Cho,

Jeong

et al. 2024

J. Microbiol. Biotechnol.

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This study analyzed the effects of Ca 2+ metal ions among culture medium components on the Chlorella sorokiniana strain DSCG150 strain cell growth. The C. sorokiniana strain DSCG150 grew based on a multiple fission cell cycle and growth became stagnant in the absence of metal ions in the medium, particularly Ca 2+ . Flow cytometry and confocal microscopic image analysis results showed that in the absence of Ca 2+ , cell growth became stagnant as the cells accumulated into four autospores and could not transform into daughter cells. Genetic analysis showed that the absence of Ca 2+ caused upregulation of calmodulin ( calA ) and cell division control protein 2 ( CDC2_1 ) genes, and downregulation of origin of replication complex subunit 6 ( ORC6 ) and dual specificity protein phosphatase CDC14A ( CDC14A ) genes. Analysis of gene expression patterns by qRT-PCR showed that the absence of Ca 2+ did not affect cell cycle progression up to 4n autospore, but it inhibited Chlorella cell fission (liberation of autospores). The addition of Ca 2+ to cells cultivated in the absence of Ca 2+ resulted in an increase in n cell population, leading to the resumption of C. sorokiniana growth. These findings suggest that Ca 2+ plays a crucial role in the fission process in Chlorella .

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Grand Challenges in Microalgae Domestication

Cited by 7 publications

References 62 publications

Harnessing genetic engineering to drive economic bioproduct production in algae

Harnessing genetic engineering to drive economic bioproduct production in algae

The next era of crop domestication starts now

The Impact of Calcium Depletion on Proliferation of Chlorella sorokiniana Strain DSCG150

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