Grandisine A (I) and B (II), Novel Indolizidine Alkaloids with Human δ‐Opioid Receptor Binding Affinity from the Leaves of the Australian Rainforest Tree Elaeocarpus grandis.

Carroll, Anthony R.; Arumugan, Garrie; Quinn, Ronald J.; Redburn, Joanne; Guymer, Gordon P; Grimshaw, Paul

doi:10.1002/chin.200533241

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Bioactivities Of Indolizidine Alkaloids1

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2020

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“…A known ((−)‐isoelaeocarpiline) and two novel ( grandisines A and B [ 79−80 , Figure 11A]) indolizidine alkaloids were isolated from Elaeocarpus grandis leaves 100 . The three compounds exhibited IC 50 values of 2.7, 52.2, and 11 μM, respectively, to inhibit the binding of [ 125 I]‐deltorphin II to HEK cell membranes expressing recombinant human δ‐opioid receptors.…”

Section: Bioactivities Of Indolizidine Alkaloidsmentioning

confidence: 99%

Biologically active indolizidine alkaloids

Zhang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

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Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of important biological activities. In this review, we discuss the biological activity and pharmacological effects of indolizidine alkaloids and offer new avenues toward the discovery of new and better drugs based on these naturally occurring compounds.

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Section: Bioactivities Of Indolizidine Alkaloidsmentioning

confidence: 99%