Granular Cell Dermatofibroma: When Morphology Still Matters

Cazzato, Gerardo; Colagrande, Anna; Cimmino, Antonietta; Marrone, Maricla; Stellacci, Alessandra; Arezzo, Francesca; Lettini, Teresa; Resta, Leonardo; Ingravallo, Giuseppe

doi:10.3390/dermatopathology8030041

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…The positivity to CD68 does not suggest a fibrohistiocyte-derived tumor, rather the accumulation of lysosomes of granular cells. 13 In 2017, intense immunoexpression of CD10 was shown in four cases of NNGCT, and also found the evidence of folliculocentricity in histopathologic histopathologically, suggesting that NNGCT may represent a dermal root sheath fibroma. 14 However, NNGCTs of the oral cavity, with no follicular structures also have been reported.…”

Section: Discussionmentioning

confidence: 88%

“…Although previous studies tried to find an appropriate immunohistochemical panel, NNGCTs usually show negative staining for S‐100, SMA, desmin, CD34, and melanocytic markers (HMB‐45 or Melan‐A), revealing no obvious origin of the cells. The positivity to CD68 does not suggest a fibrohistiocyte‐derived tumor, rather the accumulation of lysosomes of granular cells 13 . In 2017, intense immunoexpression of CD10 was shown in four cases of NNGCT, and also found the evidence of folliculocentricity in histopathologic histopathologically, suggesting that NNGCT may represent a dermal root sheath fibroma 14 .…”

Section: Discussionmentioning

confidence: 99%

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Dermatofibroma‐like dermal non‐neural granular cell tumor

et al. 2022

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Non‐neural granular cell tumor (NNGCT) is a rare tumor with uncertain lineage. It presents as an asymptomatic polypoid or plaque‐like lesion, especially on trunk. Because the granular cells are usually strongly reactive with S‐100 stain, conventional granular cell tumors (GCTs) are regarded as those of neural or Schwann cell origin. Unlike GCTs, NNGCT is not reactive for S‐100 protein and is thought to derive elsewhere, presumably from mesenchymal stem cells. A 20‐year‐old woman presented with a solitary, dermatofibroma‐like, brownish nodule on her right arm. The lesion developed 3 months before presentation without subjective symptoms. Histopathologic examination revealed a grenz zone overlying a poorly circumscribed tumor extending through the reticular dermis. The tumor cells were large and polygonal, and they had numerous eosinophilic small granules in the cytoplasm. Immunohistochemical stains were positive for CD68, vimentin, factor XIIIa, CD10, and cyclin D1. Stains for S‐100 protein, neuron‐specific enolase, and CD34 were negative. Based on these findings, the lesion was diagnosed as dermal NNGCT.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Dermatofibroma‐like dermal non‐neural granular cell tumor

et al. 2022

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“…Although DFSP possesses female predominance at 20-40 years old [ 41 ], in the current study, it was recorded in four males and only one female but within the same age range. These types of tumors are composed of fibroblastic, myofibroblastic, and histiocytic cells with eosinophilic cytoplasm that are generally positive for CD68 and negative for CD34 [ 42 ]. DFSP that showed CD34+ occurred rarely and they were found in about 5% of the DFSP [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

The Burden of Skin Cancers in Saudi Arabia Through 2011-2022

AlOtaibi,

Basfar,

Jawhari

et al. 2023

Cureus

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Introduction Skin cancers are classified into melanoma and non-melanoma or keratinocyte cancers. No recent data are found about the epidemiology of skin cancers in Saudi Arabia. The current study aims to determine the burden of skin cancer in the last 11 years from 2011 to 2022. Methods Patients who were diagnosed with any type of skin cancer were enrolled in the study. The diagnosis was conducted based on histopathology and immunohistochemistry. Different variables like age, type of cancer, type of lesions, and treatment approach used were measured. Results A total of 91 patients were diagnosed with skin cancers during the study period. The head and neck were the most common sites for skin cancers. Only 4/91 cases reported invasive melanoma. Both squamous cell carcinoma (SCC) (34/91) and basal cell carcinoma (BCC) (28/91) were found to be the most reported skin cancers. Other cancers including mycosis fungoides (MF) (10/91), Kaposi’s sarcoma (6/91), and dermatofibrosarcoma protuberans (DFSP) (5/91) were also detected. The rest of the detected tumors were rarely detected. Aggressive CD4+/CD4+/CD8+ MF was more prevalent than CD3+/CD4+/CD8- MF cancer cases. CD34+ /S100- DFSP cancers were evident in most of the DFSP cases. Human herpes virus 8 was detected in all Kaposi’s sarcoma cases and all of them were HIV-confirmed cases. Surgical treatment was the most frequently used approach to treat skin cancers, followed by phototherapy (9.9%), surgical/radiotherapy (5.5%), surgical/chemotherapy (4.4%), chemotherapy (3.3%), and then chemoradiotherapy immunotherapy (1.1%). Conclusion The incidences of SCC and BCC are relatively high in comparison to other types of skin cancers with the surgical intervention being most frequently used.

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“…On histology, DF consisted of fibroblast-like cells and histiocytes with eosinophilic cytoplasm containing granules or microvacuoles. The neoplastic cells were separated by collagen bundles and some inflammatory cell [5]. They were positive for CD68 and negative for Melan A, CD34, CD10, and S100.…”

Section: Introductionmentioning

confidence: 99%

“…They include common fibrous histiocytoma, myxoid, lichenoid, epithelioid, balloon cell, atrophic, clear cell, cellular, hemosiderotic, aneurysmal, lipidized, atypical, palisading, granular cell, keloidal, lichenoid, and signet ring cell. A single lesion can show histological features of several variants [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Dermatofibromas with Aberrant Expression of CD34 Protein: A Systematic Review and a Reappraisal of Clinicopathological Features and Histogenesis

Hussein

2023

Diagnostics

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Background: Dermatofibromas (DFs) are benign fibrohistiocytic lesions that usually do not express CD34 protein. This study aimed to analyze the literature concerning the immunohistological and ultrastructural features of DFs. It also related these features to the histogenesis of these lesions. Methods: This study included a PubMed literature search for studies addressing the clinicopathological, ultrastructural, and immunohistochemical features of DFs. It also presented some current cases of CD34-negative DFs and a subset of these lesions with aberrant expression of this protein. Results: Analysis of the PubMed literature revealed that DFs with an aberrant expression of CD34 are rare tumors that commonly affect the extremities of adult females. Separating these tumors from dermatofibrosarcoma protuberans (DFSP, CD34-positive tumors) requires using a large panel of immunostains. Ultrastructurally, DFs are composed of diverse cell types, including cells with histiocytic, myofibroblastic, and fibroblastic features. An analysis of the DFs described by this study revealed that cases with an aberrant expression of CD34 protein had slightly high mean age and male sex predominance when compared to CD34-negative cases. The former commonly affected the extremities. There was no evidence of local recurrence or distant metastasis on follow-up. Conclusions: DFs have the potential to express CD34 protein, defining a rare aberrant phenotype, which was not associated with any differences in the outcome as compared to CD34-negative DFs.

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Granular Cell Dermatofibroma: When Morphology Still Matters

Cited by 8 publications

References 14 publications

Dermatofibroma‐like dermal non‐neural granular cell tumor

Dermatofibroma‐like dermal non‐neural granular cell tumor

The Burden of Skin Cancers in Saudi Arabia Through 2011-2022

Dermatofibromas with Aberrant Expression of CD34 Protein: A Systematic Review and a Reappraisal of Clinicopathological Features and Histogenesis

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