Granular cell tumor experience at a comprehensive cancer center

Malignant granular cell tumor: Clinical features and long‐term survival

“…This study confirmed characteristics of GCT as well as its management previously described in published reports such as a predilection to affect females more often than males, occurrence in a wide variety of locations, and excision alone as the primary treatment . Benign GCT appears to occur most often in the head neck region, while, as found in this study, malignant GCT occurs most frequently in the soft tissues and skin …”

“…We performed an analysis of mGCT using a large database representa- This study confirmed characteristics of GCT as well as its management previously described in published reports such as a predilection to affect females more often than males, 4-9 occurrence in a wide variety of locations, [10][11][12][13][14] and excision alone as the primary treatment. 1,4,8,9,14,15 Benign GCT appears to occur most often in the head neck region, while, as found in this study, malignant GCT occurs most frequently in the soft tissues and skin. 1,5,7 As mentioned above, the primary treatment of GCT has traditionally been surgical excision, without regional lymphadenectomy.…”

“…One report described the case of a 54‐year old male treated with Pazopanib after undergoing palliative resection of recurrent malignant GCT of the right upper back that metastasized to the right axillary lymph nodes, right thigh and lung . Chemotherapy has largely been used for locally recurrent disease or metastasis . The use of radiotherapy has also been described as both adjuvant and palliative therapies …”

Isolated limb infusion as a treatment option for malignant granular cell tumour

“…Many tumours are not clearly malignant until they recur or metastasise. Patients with multifocal tumours are more likely to develop recurrence, although the criteria to determine multifocal tumours versus metastatic tumours are not clear 2. Wide local excision is accepted as the treatment of choice and generally results in excellent long-term control of GCTs,3 benign and atypical.…”

“…Wide local excision is accepted as the treatment of choice and generally results in excellent long-term control of GCTs,3 benign and atypical. Interestingly, the impact of positive margins varies, with some authors finding no correlation between margin status and recurrence rates 2. After resection, no standard treatment exists for MGCTs.…”