Granular cell tumor in differential diagnosis of tumors of the breast

Features of Benign Granular Cell Tumor on Fine Needle Aspiration

“…7,9 Cytologic descriptions of benign GCT have been limited mainly to bronchial brushings and washings 4,11,13,15,21,22,31 or fine needle aspiration (FNA) and touch preparations from the breast. 1,3,10,16,20,24,27,29,30 FNA cases of GCT from the skin 19 and soft tissue 8 have been rarely previously reported. Below we present the FNA findings of three cases of benign GCT, two from the thigh and the third from the breast, and discuss the differential diagnosis.…”

Granular cell tumor of the breast: Definitive diagnosis by sonographically guided percutaneous biopsy

“…GCT may appear on gross pathologic inspection as either a well-circumscribed mass or a stellate lesion that infiltrates the surrounding breast tissue. 7 Clinically, GCT may present in a manner similar to breast carcinoma, with skin dimpling or fixation. 5 Mammographically, GCT can simulate a primary malignancy by displaying smooth, lobular, or, most suspiciously, spiculated borders and even enlarging on serial examinations.…”

“…13 Several authors have successfully employed FNAB to diagnose GCT, a tumor composed of cells with distinctive, poorly defined borders and copious granular cytoplasm. 5,7,10,14 Two of those authors utilized sonographic guidance. 5,10 However, because of the inability of FNAB to provide a full histologic section, including intracellular architecture, a precise diagnosis of GCT could not always be rendered by this technique.…”

Granular cell tumor of the neurohypophysis: Report of a case with intraoperative cytologic diagnosis

“…On histologic sections and cytological smears, GCT is composed of nests of large cells with small round to oval nucleus and abundant granular eosinophilic cytoplasm, arranged as individual cells or in clusters. Although the cytology of GCT in other sites has been reported in the English literature, [7][8][9][10][11][12][13][14][15][16][17] to our knowledge, there has been no report on the intraoperative touch/squash cytology of this tumor. We report the first case of GCT of the neurohypophysis diagnosed on cytological preparations during an intraoperative consultation, illustrating the value of intraoperative cytology as a well recognized and reliable diagnostic modality for rapid interpretation and even classification of neuropathologic specimens.…”