Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch

Henzan, Tomoko; Yamauchi, Takuji; Yamanaka, I; Sakoda, Teppei; Semba, Yuichiro; Hayashi, Morito; Kikushige, Yoshikane; Mishima, Hiroyuki; Ishimura, Masataka; Koga, Yuhki; Miyamoto, Toshihiro; Ohga, Shouichi; Akashi, Koichi; Maeda, Takahiro; Kunisaki, Yuya

doi:10.1007/s12185-021-03207-6

Cited by 2 publications

(6 citation statements)

References 34 publications

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“…Next, we demonstrated that a high HES130/0.4 concentration in the separation chamber of Spectra Optia enabled stable granulocyte yields regardless of donor hematocrit values. As previously reported, 13 in granulocyte apheresis using the approach of low HES130/0.4 concentration in the separation chamber (Figure 3A), a low donor hematocrit negatively affected granulocyte CE. Erythrocyte sedimentation rate has been shown to be proportional to HES concentration 18 .…”

Section: Discussionsupporting

confidence: 79%

“…For donor safety, it might be crucial to minimize the processing time and PBV. In contrast, the granulocyte CE in the m0.8 group was similar to the hHES group and was not inferior to other reports with HES130/0.4 12,13 . Although there was no significant difference, the CE tended to be highest with the m0.44 method, with the slowest flow rates of 40 mL/min among m0.46, m0.44, and m0.37.…”

Section: Discussionsupporting

confidence: 46%

“…Notably, the collection by m0.8 has a faster processing time and fewer PBV to achieve successful apheresis compared to the previous studies using HES130/0.4. 12,13 Maintaining a high HES130/0.4 concentration in the separation chamber might have resulted in the efficient collection of granulocytes. Firstly, we observed that the m0.8 group performed granulocyte apheresis in a shorter time and had less PBV than other groups.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, every procedure in the m0.8 group could provide the desired granulocyte counts of 1 × 10 10 . Notably, the collection by m0.8 has a faster processing time and fewer PBV to achieve successful apheresis compared to the previous studies using HES130/0.4 12,13 . Maintaining a high HES130/0.4 concentration in the separation chamber might have resulted in the efficient collection of granulocytes.…”

Section: Discussionmentioning

confidence: 96%

“…The development of hematological abnormalities and diffused tissue storage has been reported in patients with renal failure who had excessive HES exposure 11 . Recent reports demonstrated that sufficient granulocytes could be harvested via apheresis using a medium molecular weight HES (mHES) (HES130/0.4: Voluven®; Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan) 12–14 . HES130/0.4 is a third‐generation HES characterized by an average molecular weight of 130,000 Dalton and a molar substitution of 0.4.…”

Section: Introductionmentioning

confidence: 99%

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Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch

Kondo

Fujii

et al. 2023

Transfusion

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Background Granulocyte transfusion therapy is a rational therapeutic option for patients with prolonged, severe neutropenia. Although high molecular weight hydroxyethyl starch (hHES) facilitates the separation of red blood cells during granulocyte collection, renal dysfunction has been noted as a potential side effect. HES130/0.4 (Voluven®) is a medium molecular weight HES (mHES) with superior safety profiles compared to hHES. Although HES130/0.4 is reportedly effective in the collection of granulocytes, we lack studies comparing the efficiency of granulocyte collection using HES130/0.4 and hHES. Study Design and Methods We retrospectively collected the data from 60 consecutive apheresis procedures performed on 40 healthy donors at the Okayama University Hospital between July 2013 and December 2021. All procedures were performed using the Spectra Optia system. Based on the HES130/0.4 concentration in the separation chamber, granulocyte collection methods using HES130/0.4 were classified into m0.46, m0.44, m0.37, and m0.8 groups. We used HES130/0.4 and hHES groups to compare the various sample collection methods. Results The median granulocyte collection efficiency (CE) was approximately 24.0% and 28.1% in the m0.8 and hHES groups, respectively, which were significantly higher than those in the m0.46, m0.44, and m0.37 groups. One month following granulocyte collection with HES130/0.4, no significant changes were observed in serum creatinine levels compared to those before the donation. Conclusion Therefore, we propose a granulocyte collection approach employing HES130/0.4, which is comparable to the use of hHES in terms of the granulocyte CE. A high concentration of HES130/0.4 in the separation chamber was considered crucial for granulocyte collection.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 46%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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