Granulokinetics in normal dogs

Raab, S. O.; Athens, J. W.; Haab, O.; Boggs, Dane R.; Ashenbrucker, Helen; Cartwright, G. E.; Wintrobe, M. M.

doi:10.1152/ajplegacy.1964.206.1.83

Cited by 34 publications

(16 citation statements)

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“…Therefore, except as otherwise noted, in subsequent studies 4.5 mg of DFP3' was given to each dog, since this amount resulted in suitable radioactivity levels. In certain of the studies, blood was labeled in vitro and returned to the circulation of the donor (5). All blood samples for leukocyte isolation and determination of specific activity were obtained by jugular puncture.…”

Section: Methodsmentioning

confidence: 99%

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Leukokinetic Studies. IX. Experimental Evaluation of a Model of Granulopoiesis*

Boggs¹,

Athens²,

Cartwright³

et al. 1965

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 99%

“…The techniques of separating dog granulocytes from whole blood and determining their specific activity (counts per minute per milligram leukocyte nitrogen) have been reported (5).…”

Section: Methodsmentioning

confidence: 99%

Leukokinetic Studies. IX. Experimental Evaluation of a Model of Granulopoiesis*

Boggs¹,

Athens²,

Cartwright³

et al. 1965

J. Clin. Invest.

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“…The rate of decline of blood granulocyte specific activity (BGSA) is then determined. In normal dogs in a steady state, the BGSA declines exponentially with a t4 of 4-8 hr (9).…”

Section: Leukocytes Labeled In Vitromentioning

confidence: 97%

Neutrophil Kinetics in Acute Infection*

Marsh¹,

Boggs²,

Cartwright³

et al. 1967

J. Clin. Invest.

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141

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Abstract. Neutrophil kinetics of acute experimental infection were studied with diisopropylfluorophosphate-32P labeling in 31 dogs inoculated intrabronchially with pneumococci. In vitro neutrophil labeling indicated a rapid transit time through the blood in early infections, with an elevated marginal granulocyte pool sometimes preceding an elevation of the circulating granulocyte pool. 13 hr after infection, the circulating and total blood granulocyte pools were increased but the rate of neutrophil transit through the blood was normal. During the recovery from infection there was a marked prolongation of neutrophil blood transit time, suggesting virtually complete cessation of bone marrow release of neutrophils into the blood. Labeling of neutrophils in vivo indicated an increased rate of emptying of the bone marrow storage pool proportional to the severity of infection as measured by the fever index. The change in the blood ratio of nonsegmented to segmented neutrophils was a much more accurate index of the severity of infection than the blood granulocyte concentration, correlating significantly with the fever index.

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“…Because the first two points reflect the usual early drop in leukocytes, they were not included in the calculation. An estimated 43% of the radioactivity injected in neutrophils remained in the circulation as calculated by the method of Raab et al (3). The halflife of the neutrophils was 4.03 h.…”

Section: Resultsmentioning

confidence: 99%

“…The neutrophil is a short-lived cell that matures in the bone marrow and has a half-life in the blood of 3.2-6.7 h, depending on the species (1)(2)(3). Although the synthesis and disappearance of blood neutrophils has been extensively studied, relatively few studies have been done on the fate of neutrophils that leave the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil turnover in normal rabbit lungs.

Cohen¹,

Rossi²,

Geczy³

et al. 1982

J. Clin. Invest.

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A B S T R A C T Neutrophil turnover was studied in the blood and alveoli of normal rabbits. Blood neutrophil turnover was examined by two different methods. In the first method, donor rabbit neutrophils were labeled in vivo by injecting tritium-labeled thymidine intravenously. After 72 h recipient rabbits received blood from the donors. The decline of the specific radioactivity of blood neutrophils was used to determine that their half-life was 4.03 h. In the second method, rabbit peritoneal exudative neutrophils were elicited with oyster glycogen. These cells were labeled with "'Indium oxine and infused into the blood of recipient animals. By their decline in specific radioactivity, the half-life of the blood neutrophil was 4.08 h. These halflives are not significantly different.Lung lavage was performed on the animals that received the "'Indium-labeled neutrophils and the turnover time of the lung neutrophil was found to be 2.63 h. The turnover of the alveolar neutrophil pool accounted for only 0.19% of the total turnover of the blood neutrophils. Therefore, the lung appears to contribute only minimally to the total capacity of the body to dispose of neutrophils.

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Granulokinetics in normal dogs

Cited by 34 publications

References 0 publications

Leukokinetic Studies. IX. Experimental Evaluation of a Model of Granulopoiesis*

Leukokinetic Studies. IX. Experimental Evaluation of a Model of Granulopoiesis*

Neutrophil Kinetics in Acute Infection*

Neutrophil turnover in normal rabbit lungs.

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