Granuloma Annulare

Patrizi, Annalisa; Neri, Iria

doi:10.1002/9781119142812.ch82

Cited by 3 publications

(6 citation statements)

References 122 publications

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“…The biopsy can reveal palisading granulomas, collagen degeneration, mucin, and a lymphohistiocytic infiltrate. 9,13,14 This study determined the clinical and histopathologic features in patients with GA for the first time in Iran. According to our study this disease predominantly affected middle-aged persons.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic evaluation of granuloma annulare: Study of 136 Iranian cases, south of Iran

Sari Aslani,

Pouraminaee,

Sepaskhah

et al. 2023

Skin Health and Disease

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Background and ObjectivesGranuloma annulare (GA) is a benign skin disorder with various histopathologic features that are rarely investigated in Iranian population. We performed this study to find out the clinical and histopathologic features of GA in our referral centre.MethodsOne hundred‐thirty‐six patients with biopsy‐proven GA were reviewed. Clinical data and pathological features were recorded.ResultsOne hundred‐eight female patients and 28 male patients (Female/male ratio: 3.85) with mean age of 42.54 ± 21.2 years (range: 2–83 years) were recruited. Eighty‐eight (64.7%) patients had interstitial infiltrative pattern and 48 (35.3%) patients had complete palisading granulomas. The infiltrate occupied both upper and lower dermis in most of the cases (67.7%). Significant mucin was detected more commonly in complete GA compared to interstitial GA (p = 0.019), but inflammation degree, eosinophils, plasma cells, and giant cells were not different between two subtypes of GA (p > 0.05). The significant inflammation contained more significant plasma cells (p = 0.006). The significantly more giant cells were detected in patients between 20 and 60 years of age (p = 0.015); but other factors were not different between age groups.ConclusionsIn our study, the prevalence of GA in women was significantly higher than in men. Interstitial GA was the more common histological subtype and the inflammation was less severe and the infiltrate was mostly pandermal in our cases. More severe inflammation contained more plasma cells, and more dense giant cells were seen in middle aged patients.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic evaluation of granuloma annulare: Study of 136 Iranian cases, south of Iran

Sari Aslani,

Pouraminaee,

Sepaskhah

et al. 2023

Skin Health and Disease

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“…GA is a self-limited, cutaneous reaction of unknown etiology that may be triggered by infections, vaccinations, or local minor trauma in children. 7 Diagnosis is typically clinical but can be confirmed by histology, which is characterized by a mucinous degenerating core of collagen and a surrounding infiltrate of lymphocytes and histiocytes. 7 To our knowledge, GA-like id reaction to MC has not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

Granuloma Annulare-Like Id Reaction to Inflamed Molluscum Contagiosum: A Case Report

Jicha,

Nieman,

Morrell

2023

Clin Med Insights Pediatr

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Molluscum contagiosum (MC) is a viral cutaneous infection common in children. It is characterized by umbilicated, skin-colored papules that typically resolve without treatment over several months to years. Immune response to the virus may cause inflammatory reactions, including molluscum dermatitis, inflamed molluscum, Gianotti-Crosti syndrome-like reaction, erythema annulare centrifugum, or even a generalized id reaction (a reactive inflammatory process driven by a separate condition that stimulates the immune system). We report a unique case of a granuloma annulare-like id reaction secondary to immune recognition of MC in a pediatric patient followed by rapid resolution of their MC.

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“…A diverse assortment of therapies for GGA has been reported, yet missing an algorithm for treatment choices ( 4 ). LGA is characterized by less than ten asymptomatic skin papules with a circular appearance mainly localized on the dorsum of the hands and feet ( 5 , 6 ). While LGA occurs in adults and children, SGA is a condition postulated to occur mainly during childhood ( 1 , 2 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…SGA consists of solid, non-tender, non-inflammatory, solitary, or multiple subcutaneous lumps. These lesions are commonly located above bony prominences, such as the anterior side of the lower legs, the dorsum of the hands and feet, and the scalp ( 5 , 8 ). LGA and SGA lesions spontaneously regress without any treatment within a couple of years ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…As a result, children often undergo several unavailing investigations before a biopsy is performed to rule out malignancy and establish an adequate SGA diagnosis. Incisional or excisional biopsy is the intervention preferred since punch biopsy may yield false negative results as it may miss the necrobiotic mucin-containing areas, characteristic of the SGA lesion ( 2 , 5 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

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The epifascial cap: A typical imaging sign for subcutaneous granuloma annulare in children

et al. 2023

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ObjectivesSubcutaneous granuloma annulare (SGA) is a rare, self-limiting granulomatous disease in children, commonly diagnosed by histopathology following biopsy or surgical excision. This study aimed to identify imaging clues for SGA that could expedite accurate diagnosis and avoid the need for biopsy in children.MethodsWe retrospectively analyzed complete hospital records of all children diagnosed with SGA at our institution from January 2001 to December 2020. Detailed disease history, imaging findings, management, and outcome were evaluated.ResultsWe identified 28 patients (20 girls) at a median age of 3.75 (range 1–12.5 years). Ten patients presented with multiple lesions. Most lesions were located on the lower extremities (n = 26/41). Ultrasound examinations were performed on all patients, and 12 (43%) patients also received an MRI. Surgical intervention was conducted in 18 (64%) patients either by incisional biopsy (n = 6) or total excision of the lump (n = 12). In all patients who did not undergo surgery, SGA resolved spontaneously. A careful review of the MRIs led to the discovery of a characteristic imaging shape of SGA lesions: the epifascial cap with a typical broad circular base laying on the fascia, extending towards the subdermal/dermal tissue. This distinctive shape was evident in every patient in our cohort.ConclusionsThe “Epifascial Cap Sign” is a specific imaging sign for SGA, which to the best of our knowledge, helps distinguish this disease from other subcutaneous lesions. Recognition of this novel diagnostic sign combined with the historical and physical findings should enable clinicians to establish SGA diagnosis easily and diminish the need for further invasive diagnostic procedures.

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Granuloma Annulare

Cited by 3 publications

References 122 publications

Clinicopathologic evaluation of granuloma annulare: Study of 136 Iranian cases, south of Iran

Clinicopathologic evaluation of granuloma annulare: Study of 136 Iranian cases, south of Iran

Granuloma Annulare-Like Id Reaction to Inflamed Molluscum Contagiosum: A Case Report

The epifascial cap: A typical imaging sign for subcutaneous granuloma annulare in children

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