Granulomatous Pulmonary Disease Secondary to Alternaria

Lobritz, Richard W.; Roberts, Thomas H.; Marraro, Robert V.; Carlton, Paul K.; Thorp, Douglas J.

doi:10.1001/jama.1979.03290320038028

Cited by 28 publications

(5 citation statements)

References 2 publications

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“…6 Alternaria has been implicated in several cases of keratomycosis, 7 osteomyelitis, 8 sinusitis, 9 peritonitis, 10 or granulomatous pulmonary nodules. 11 Cutaneous infections caused by Alternaria species are rare, but constitute the majority of pathologic processes reported in human beings, mostly observed in immunocompromised hosts.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous alternariosis in transplant recipients: Clinicopathologic review of 9 cases

Gilaberte

Bartralot²,

Torres

et al. 2005

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Cutaneous alternariosis in transplant recipients: Clinicopathologic review of 9 cases

Gilaberte

Bartralot²,

Torres

et al. 2005

Journal of the American Academy of Dermatology

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“…Alternaria is another fungal hyphus that has been reported rarely to cause necrotizing lung granulomas 81 …”

Section: Infectious Granulomasmentioning

confidence: 99%

Pathological diagnosis of granulomatous lung disease: a review

2007

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Granulomas in the lung are common diagnostic problems encountered by pathologists. They occur in a wide range of pulmonary conditions, ranging from common entities to uncommon ones and including both infections and non-infectious diseases. This review summarizes the main histological features that help distinguish various granulomatous lung diseases. It concentrates on the most important and common entities that may be encountered and emphasizes helpful features in the differential diagnosis.

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“…However, it can also cause several different types of human infections, e.g. paranasal sinusitis, ocular infections, onychomycosis, cutaneous and subcutaneous infections [10], and, more rarely, granulomatous pulmonary disease [15], soft palate perforation [16] and disseminated disease [17,18]. Occasionally, Alternaria has been reported as a contaminant of soft contact lenses [19], and has also been isolated from an emollient cream [20].…”

Section: Introductionmentioning

confidence: 99%

Alternaria infections: laboratory diagnosis and relevant clinical features

Pastor

Guarro

2008

Clinical Microbiology and Infection

190

217

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The genus Alternaria contains several species of melanized hyphomycetes that cause opportunistic human infections. The published literature contains 210 reported cases of human alternarioses between 1933 and the present day. The most frequent clinical manifestations are cutaneous and subcutaneous infections (74.3%), followed by oculomycosis (9.5%), invasive and non-invasive rhinosinusitis (8.1%) and onychomycosis (8.1%). Immunosuppression is frequently associated with cutaneous and subcutaneous infections and rhinosinusitis. The most important risk factors for cutaneous and subcutaneous infections are solid organ transplantation and Cushing's syndrome, and those for rhinosinusitis are bone marrow transplants. Having been exposed to soil and garbage is common in all cases of oculomycosis, with corticotherapy being a risk factor in 50% of these cases. Previous contact with soil and/or trauma to the nails is associated with most cases of onychomycosis. In general, alternariosis shows a good response to conventional antifungal drugs. On some occasions, steroid suppression or reduction is sufficient to resolve an infection. Itraconazole is the antifungal drug used most frequently to successfully treat onychomycosis and cutaneous and subcutaneous infections. Posaconazole and voriconazole are promising therapeutic options, with the latter being especially so for oculomycosis.

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Granulomatous Pulmonary Disease Secondary to Alternaria

Cited by 28 publications

References 2 publications

Cutaneous alternariosis in transplant recipients: Clinicopathologic review of 9 cases

Cutaneous alternariosis in transplant recipients: Clinicopathologic review of 9 cases

Pathological diagnosis of granulomatous lung disease: a review

Alternaria infections: laboratory diagnosis and relevant clinical features

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