Granulomatous slack skin: case report with electron microscopic features

Wang, Bo; Zheng, Jie; Wang, Hongwei

doi:10.5070/d3257044802

Cited by 2 publications

(2 citation statements)

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“…47 The electron microscopy can be useful to observe the fragmented elastin fibers in macrophages in addition to the Weigert elastin stain. 48…”

Section: Discussionmentioning

confidence: 99%

“…47 The electron microscopy can be useful to observe the fragmented elastin fibers in macrophages in addition to the Weigert elastin stain. 48 Recognizing the necessity to develop a standardized diagnostic criteria for GMF, we propose a diagnostic algorithm for GMF (Table 3), which is modeled after the diagnostic algorithm for the early MF by Pimpinelli N. et al and International Society of Cutaneous Lymphoma. 18 The early MF algorithm was validated by Vandergriff T. et al as a statistically valid method to diagnose MF with 87.5% sensitivity and 60% specificity (Fisher exact test, P = 0.009).…”

Section: Discussionmentioning

confidence: 99%

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Subtlety of Granulomatous Mycosis Fungoides: A Retrospective Case Series Study and Proposal of Helpful Multimodal Diagnostic Approach With Literature Review

Lenskaya

Moll

Hussein

et al. 2022

The American Journal of Dermatopathology

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:Granulomatous mycosis fungoides (GMF) harbors a worse prognosis compared with classic MF and remains a significant diagnostic dilemma. We analyzed clinicopathologic, immunophenotypic, and molecular characteristics of GMF to develop a diagnostic algorithm. Our methodology involved a retrospective case series study of patients with GMF from our database between 2014 and 2020. A total of 8 patients with 9 biopsies of GMF were identified. Skin manifestations had variable clinical phenotype. Histologically, all cases demonstrated atypical CD4+ T-cell infiltrate with scant in 50% (n = 4), focal 37.5% (n = 3), and absent 25% (n = 2) epidermotropism. Granuloma formation was seen in 77.8% biopsies (n = 7) with sarcoid-type granulomas in 57.1% (n = 4) and granuloma annulare-like type in 42.9% (n = 3). In 66.7% of biopsies (n = 6), the CD4:CD8 ratio was >4:1 and 66.6% (n = 6) of biopsies showed ≥50% loss of CD7 expression. T-cell receptor gene rearrangement studies performed on biopsy sections were positive in all biopsies (n = 6), whereas peripheral blood T-cell receptor gene rearrangement studies did not identify clonality. In conclusion, GMF has subtle or absent epidermotropism and variable granulomatous reaction; thus, the diagnosis requires a multimodal approach, and our proposed algorithm provides a framework to approach this diagnostic challenge.

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“…47 The electron microscopy can be useful to observe the fragmented elastin fibers in macrophages in addition to the Weigert elastin stain. 48…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%