Granulosa cell tumor of ovary: A systematic review of recent evidence

Zigron, Roy; Haj-Yahya, Rani; Matan, Liat; Rottenstreich, Amihai

doi:10.1016/j.ejogrb.2018.04.002

Cited by 49 publications

(63 citation statements)

References 25 publications

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“…ГКОЯ взрослого типа составляют более 90 % всех ГКОЯ и около 1 % всех овариальных неоплазий. Они чаще встречаются у женщин в пери-и постменопаузальном периодах, при этом средний возраст пациенток с данной нозологией составляет 50-55 лет [1,6,7]. Характерной особенностью взрослого типа ГКОЯ является выраженная гормональная активность с гиперпродукцией стероидных и пептидных гормонов, которая обусловливает клиническую картину и течение заболевания [8,9].…”

Section: экспериментальные статьиunclassified

Inhibin B in stromal-cell ovarian tumors

et al. 2020

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Background. Tumors of stroma of the sex cord include a family of tumors that are diverse in structure and biological characteristics, including hormone-active ovarian tumors, such as granulosa cell tumor (GCT) of the ovary and a tumor from Sertoli–Leydig cells. For these types of tumors, of particular importance is the analysis of biochemical markers, among which the most promising is inhibin B.The objective of the study. Comparative analysis of inhibin B levels in the blood serum of patients with stromal cell tumors and other types malignancies.Materials and methods. 64 patients with primary ovarian tumors were examined: 31 – GCT of the ovary, 16 – tumors from Sertoli–Leydig cells, 17 – adenocarcinomas. Comparison group – 20 patients with malignant tumors of other localizations, control – 74 healthy women and 37 patients with benign ovarian tumors. Inhibin B was determined in blood serum using the standardized Inhibin B Gen II ELISA (Beckman Coulter, USA) immunoassay.Results. The analysis of inhibin B levels in last days of the luteal phase, show an increase of marker level in patients with GCT and tumors from Sertoli–Leydig cells, while in ovarian adenocarcinomas and malignant tumors of other locations inhibin B secretion doesn’t differ from the control. The sensitivity of inhibin B in diagnostics of GCT was 93.5 %, in tumor from Sertoli–Leydig cells – 81.3 % with specificity – 100 %.Conclusion. Inhibin B is an effective biomarker of GCT and ovarian tumors from Sertoli–Leydig cells, which results must be interpreted according the functional state of the ovaries.

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Section: экспериментальные статьиunclassified

Inhibin B in stromal-cell ovarian tumors

et al. 2020

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“…The development of adult-type GCTs is often accompanied by symptoms of hormone dysregulation (e.g., amenorrhea, uterine bleeding and endometrial hyperplasia) (6,7). The clinical symptoms, diagnostic imaging, histology of surgery-obtained tumor samples and presence of tumor markers [e.g., inhibins and anti-Mullerian hormone (AMH)] provide useful information for the diagnosis of GCTs (8,9).…”

Section: Introductionmentioning

confidence: 99%

New insights into testicular granulosa cell tumors (Review)

Fang

2020

Oncol Lett

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Testicular granulosa cell tumors (TGCTs) are rare tumors of sex cord-stromal origin. TGCTs are mostly benign and can be classified into the adult type and the juvenile type. Due to the rarity of clinical cases and limited research efforts, the mechanism underpinning the development of TGCTs remains poorly understood. A landmark study has identified a forkhead box L2 mutation (C134W) in nearly all adult ovarian GCTs, but its implications in TGCTs are unclear. The present study focuses on reviewing the major signaling pathways (e.g., the transforming growth factor β signaling pathway) critical for the development of TGCTs, as revealed by genetically modified mouse models, with a goal of providing new insights into the pathogenesis of TGCTs and offering directions for future studies in this area. We posit that a comparative approach between testicular and ovarian GCTs is valuable, as granulosa cells and Sertoli cells arise from the same progenitor cells during gonadal development. Developing pre-clinical mouse models that recapitulate TGCTs will help answer the remaining questions around this type of rare tumor. Contents 1. Introduction 2. Tumors in the testes 3. TGCTs: Subtypes and histopathology 4. FOXL2 mutation in GCT development 5. Genetically modified mouse models to study TGCTs 6. Concluding remarks and future directions

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“…Although the granulosa cell tumors only represent 1% of the total number of ovarian tumors [13], they represent the most common subtype of "ovarian sexcord tumors" (70%) [8].…”

Section: Introductionmentioning

confidence: 99%

"Coffe Bean" Nucleic in a Rare Case of Ovarian Adult Granulosa Cell Tumor

Sabău

Turdean

Mărginean

2020

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Granulosa cell tumors represent only 1% of the total number of ovarian tumors. "Coffee bean" nuclei represent an extremely rare feature of these tumors. We presented the case of a 66 year-old patient that was hospitalized for abdominopelvic pain, lately to be diagnosticated with an Adult Granulosa Cell Tumor. The histopathological analysis revealed Call-Exner corpuscles and Coffee Bean" nuclei. Positive S100 marker was a particular finding in the immunohistochemical profile. Treatment strategy for this kind of cases should include surgery and adjuvant treatment and a strict follow-up of the patient for at least 5-10 years.

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Granulosa cell tumor of ovary: A systematic review of recent evidence

Cited by 49 publications

References 25 publications

Inhibin B in stromal-cell ovarian tumors

Inhibin B in stromal-cell ovarian tumors

New insights into testicular granulosa cell tumors (Review)

"Coffe Bean" Nucleic in a Rare Case of Ovarian Adult Granulosa Cell Tumor

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