Granulysin as a Marker for Early Diagnosis of the Stevens–Johnson Syndrome

Abe, Riichiro; Yoshioka, Naoya; Murata, Junko; Fujita, Yasuyuki; Shimizu, Hiroshi

doi:10.7326/0003-4819-151-7-200910060-00016

Cited by 99 publications

(75 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Very recently, we showed that granulysin levels of sera from patients with SJS/TEN are significantly elevated before the development of skin detachment or mucosal lesions. 5 The elevated serum granulysin levels decrease rapidly within 5 days after disease onset. This pattern is similar to that observed with sFasL.…”

Section: Discussionmentioning

confidence: 99%

“…3 When granulysin levels for patients with SJS/TEN in the early stage were compared with those levels for patients with ODSRs and healthy control subjects, the differences were statistically significant. 5 This novel test enables the early diagnosis of SJS/TEN in patients with cutaneous adverse drug reactions that are otherwise indistinguishable from ODSRs.…”

Section: Discussionmentioning

confidence: 99%

“…We found that both serum granulysin and sFasL are higher in patients with early-stage SJS/TEN than in patients with ODSRs. 5 Serum levels of granulysin are 100 times higher (cut off: 10 ng/mL) than those of sFasL. Based on these observations, we developed a rapid immunochromatographic assay for the detection of high-level serum granulysin to diagnose and predict the early stage of SJS/TEN.…”

Section: Abbreviations Usedmentioning

confidence: 99%

See 2 more Smart Citations

Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis

Fujita

Yoshioka

Abe

et al. 2011

Journal of the American Academy of Dermatology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Abbreviations Usedmentioning

confidence: 99%

See 1 more Smart Citation

Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis

Fujita

Yoshioka

Abe

et al. 2011

Journal of the American Academy of Dermatology

Self Cite

View full text Add to dashboard Cite

“…Granulysin is a 9- . High serum levels of granulysin have been detected 2 4 days before TEN 36 . In addition, granulysin levels are higher than perforin, granzyme, or sFasL levels in the blister fluid from TEN patients.…”

Section: Th17 Cellsmentioning

confidence: 99%

A Review of the Pathogenesis of Toxic Epidermal Necrolysis

Kinoshita

Saeki

2016

J Nippon Med Sch

View full text Add to dashboard Cite

Toxic epidermal necrolysis (TEN) is a rare skin condition, most often drug-induced, known for its skin detachment and high mortality. In general, acute TEN is considered a T-cell mediated, type IV hypersensitivity disorder. It mostly results from a cumulative effect of risks from the drug structure, drug metabolism, HLA alleles and T cell clonotypes. However, the precise mechanism of TEN is still unknown.Apoptosis or necroptosis causes keratinocytes to lose their shape and adhesion, and necrosis predominates within a few days. Total epidermal necrosis separates the epidermis from the dermis. TEN is regarded as an immune reaction with predominantly CD8+ T lymphocytes, monocytes/macrophages, and natural killer cells. Impaired regulatory T-cells, T-helper 17 cells, cytotoxic granules such as perforingranzyme and granulysin, tumor necrosis factor α, annexin, microRNA-18a-5p, and drug metabolites are all thought to be involved. From what is known, it can be assumed their mechanism is complex, and there is still much to be investigated. New findings will contribute to the identification of effective active methods of intervention. (J Nippon Med Sch 2016; 83: 216 222)

show abstract

“…A recent pilot study showed that serum granulysin levels may be raised early in the course of disease but rapidly wanes with progression of disease [95]. Further studies are required to determine whether this assay will prove to be a useful early diagnostic test for SJS/TEN.…”

Section: Diagnosismentioning

confidence: 99%

Severe Cutaneous Adverse Reactions

Fernando¹

2013

Skin Biopsy - Diagnosis and Treatment

View full text Add to dashboard Cite

Granulysin as a Marker for Early Diagnosis of the Stevens–Johnson Syndrome

Cited by 99 publications

References 5 publications

Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis

Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis

A Review of the Pathogenesis of Toxic Epidermal Necrolysis

Severe Cutaneous Adverse Reactions

Contact Info

Product

Resources

About