Granzyme K+ CD8 T cells in autoimmunity

Jonsson, Anna Helena

doi:10.1016/j.berh.2024.101930

Cited by 1 publication

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increasing body of evidence indicates that CD8 T cells play pivotal roles in the initiation, progression, pathogenesis, and protection for autoimmune diseases ( 75 , 76 ). In that regard, it is noteworthy to highlight that CD8 T cells can exert not only direct cytotoxic effects but also a myriad of actions, including indirect cytotoxicity, as well as direct and indirect non-cytotoxic functions via crosstalk with other immune and non-immune cells ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…In that regard, it is noteworthy to highlight that CD8 T cells can exert not only direct cytotoxic effects but also a myriad of actions, including indirect cytotoxicity, as well as direct and indirect non-cytotoxic functions via crosstalk with other immune and non-immune cells ( 35 ). These actions include the recruitment of other immune cells to inflammation sites, the activation of NK cells and dendritic cells to ensure antigen presentation and the induction of effector innate and adaptive immunity (mainly in an IFNγ dependent manner), the help to B cells to support antibody production, immunoregulation, and the induction of tissue healing and regeneration ( 35 , 76 , 77 ). Interestingly, memory CD8 T cells were shown to protect dendritic cells from the killing by effector cytotoxic T cells via the upregulation of an endogenous inhibitor of granzymes, thus enhancing antigen presentation and thereby augmenting the consequent induction of Th1 immune responses ( 78 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

CD8 T cells are dispensable for experimental autoimmune prostatitis induction and chronic pelvic pain development

Salazar,

Martinez,

Paira

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

IntroductionChronic Pelvic Pain Syndrome or Chronic Prostatitis (CPPS/CP) is the most prevalent urologic affliction among young adult men. It is a challenging condition to treat, which significantly decreases patient quality of life, mostly because of its still uncertain aetiology. In that regard, an autoimmune origin is a prominent supported theory. Indeed, studies in patients and in rodent models of Experimental Autoimmune Prostatitis (EAP) have provided compelling evidence suggesting a key role of CD4 Th1 cells in disease pathogenesis. However, the implication of other prominent effectors of the immune system, such as CD8 T cells, has yet to be studied.MethodsWe herein analyzed the induction of prostatitis and the development of chronic pelvic pain in EAP using CD8 T cell-deficient animals.ResultsWe found similarly elevated PA-specific immune responses, with high frequencies of specific IFNg+CD4+ and IL17+CD4+ T cells in prostate draining lymph nodes from PA-immunized either CD8 KO or wild type animals with respect to controls. Moreover, these peripheral immune responses were paralleled by the development of significant chronic pelvic pain, and accompanied by prostate histological lesions, characterized by hemorrhage, epithelial cell desquamation, marked periglandular leukocyte infiltration, and increased collagen deposition in both, PA-immunized CD8 KO and wild type animals. As expected, control animals did not develop prostate histological lesions.DiscussionOur results indicate that CD8 T cells do not play a major role in EAP pathogenesis and chronic pelvic pain development. Moreover, our results corroborate the previous notion that a CD4 Th1 associated immune response drives the induction of prostate tissue inflammation and the development of chronic pelvic pain.

show abstract

Section: Discussionmentioning

confidence: 99%