Grape seed extract neutralizes the effects of Cerastes cerastes cerastes post-synaptic neurotoxin in mouse diaphragm

Mahmoud, Yomna I.

doi:10.1016/j.micron.2012.07.007

Cited by 9 publications

(4 citation statements)

References 50 publications

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“…It has been proved to possess antimicrobial activity that is attributed to the general mode of action of the phenolics (Perumalla & Hettiarachchy, 2011). GSE has also been reported to have many pharmacological and biochemical actions such as anti-inflammatory, cardioprotective, chemopreventive, anticarcinogenic, and antioxidant activities (Mahmoud, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of grape seed extract on Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice

Molva

Baysal

2015

LWT - Food Science and Technology

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Chemical compounds studied in this article: Grape seed extract (proanthocyanidins) (PubChem CID: 108065) gallic acid (PubChem CID: 370) disodium carbonate (PubChem CID: 10340) sodium acetate trihydrate (PubChem CID: 23665405) 2,4,6-tripyridyl-s-triazine (PubChem CID: 77258) iron chloride (PubChem CID: 24380) a b s t r a c tThe present study evaluated the antimicrobial activity of grape seed extract (GSE) against Alicyclobacillus acidoterrestris vegetative cells and spores in apple juice (pH 3.82, Brix 11.3) during storage at 37 C. After 336 h, reductions in the cell numbers were 3.14, 3.55, 3.8, 4.1, and 4.63 log CFU/mL in the apple juice with 0.23, 0.45, 0.9, 1.8, and 3.6% of GSE, respectively. The Weibull was found to be the best fitted model for cell inactivation kinetics (R 2 > 0.988). Moreover, the spores produced on different sporulation media (potato dextrose agar, malt extract agar, Bacillus acidoterrestris agar, and Bacillus acidocaldarius agar) were treated with GSE (0e1.9%, v/v). While control spores in apple juice without GSE increased by 2.2e2.6 log CFU/mL within the first 48 h, 0.9% and 1.8% of GSE inhibited the growth from all spore suspensions. Finally, scanning electron microscopy (SEM) indicated that the main target of the GSE may be the membrane of A. acidoterrestris cells leading to leakage of cellular constituents and may prevent the development of spores into vegetative cells. This study highlights the potential use of the by-products of the fruit juice/ beverage industry as natural antimicrobials to inhibit the growth of A. acidoterrestris.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of grape seed extract on Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice

Molva

Baysal

2015

LWT - Food Science and Technology

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“…Of these, PA is the most abundant and purest, and is the main substance in the GSE that possesses a biological function. Studies had shown that GSE had antibacterial ( Ahn et al, 2004 ), anti-inflammatory ( Carini et al, 2001 ), antioxidant ( Luther et al, 2007 ), and anticancer ( Cheah et al, 2014 ) activities, with protective effects on host skin ( Yamakoshi et al, 2003 ), cardiovascular ( Nunes et al, 2016 ), liver ( Hassan and Al-Rawi, 2013 ), and nervous system ( Mahmoud, 2013 ). Farahat et al (2017) reported that GSE increased Newcastle disease virus antibody potency in broiler serum and effectively reduced malondialdehyde levels in meat tissue.…”

Section: Introductionmentioning

confidence: 99%

Feeding broilers with wheat germ, hops and grape seed extract mixture improves growth performance

Zou¹,

Meng²,

et al. 2023

Front. Physiol.

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In the study, Wheat germ, Hops and Grape seed extracts were made into a mixture (BX). The BX was supplemented in AA + broilers diets to investigate the effects of BX on broiler growth performance, blood indicators, microbiota, and noxious gas emissions in faeces. Four hundred and eighty 1-day-old AA + male broilers with an average initial body weight (44.82 ± 0.26) were randomly divided into four dietary treatments of six replicates each, with 20 birds per replicate. The experimental groups consisted of a group fed a basal diet and groups fed basal diet supplemented with 0.05%, 0.1%, and 0.2% BX. The trail was 42 days. The results showed that supplementing the dietary with graded levels of BX linearly increased ADG and ADFI from days 22–42 and 1–42. When dietarys supplemented with 0.2% BX significantly increased ADG and ADFI on days 22–42 and 1–42 (p < 0.05). The addition of BX reduced H2S and NH3 emissions in the faeces; the levels of E. coli and Salmonella in the faeces were significantly reduced and the levels of Lactobacillus were increased (p < 0.05). In this trial, when the diet was supplemented with 0.2% BX, faecal levels of E. coli and Salmonella were consistently at their lowest levels and Lactobacillus were at their highest. At the same time, NH3 and H2S emissions from broiler faecal also had been at their lowest levels. Conclusion: Dietary supplementation with a 0.2% BX could improve the growth performance of broilers and also reduced faecal H2S and NH3 emissions, as well as faecal levels of E. coli and Salmonella, and increased levels of Lactobacillus. Thus, BX made by Wheat germ, Hops and Grape seed extract is expected to be an alternative to antibiotics. And based on the results of this trial, the recommended dose for use in on-farm production was 0.2%.

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“…The effectiveness of GSE inhibition depends on the concentration of the extract, percentage of phenols, and the type of bacterium [ 5 ]. Furthermore, GSE was tested for its possible anti-inflammatory, cardioprotective, chemopreventive, anticarcinogenic, and antioxidant activities, which might be of pharmacological and medical importance [ 6 ]. Similar to most natural products, GSE is almost safe, with an intended uptake for up to 11 months in human studies without any significant side effects.…”

Section: Introductionmentioning

confidence: 99%

The Antimicrobial Activities of Silver Nanoparticles from Aqueous Extract of Grape Seeds against Pathogenic Bacteria and Fungi

et al. 2021

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Grape seed extract (GSE) is a natural source of polyphenolic compounds and secondary metabolites, which have been tested for their possible antimicrobial activities. In the current study, we tested the antibacterial and antifungal activities of aqueous GSE and the biosynthesized silver nanoparticles loaded with GSE (GSE-AgNPs) against different pathogens. The biosynthesized GSE-AgNPs were assessed by UV spectroscopy, dynamic light scattering (DLS), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and gas chromatography/mass spectrometry (GC/MS). The antimicrobial activities were assessed against different bacterial and fungal species. DLS analysis showed that GSE-AgNPs had a Z-Average of 91.89 nm while UV spectroscopy showed that GSE-AgNPs had the highest absorbance at a wavelength of ~415 nm. FTIR analysis revealed that both of GSE and GSE-AgNPs consisted of different functional groups, such as hydroxyl, alkenes, alkyne, and aromatic rings. Both FE-SEM and TEM showed that GSE-AgNPs had larger sizes and rough surfaces than GSE and AgNO3. The results showed significant antimicrobial activities of GSE-AgNPs against all tested species, unlike GSE, which had weaker and limited effects. More studies are needed to investigate the other antimicrobial activities of GSE.

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Grape seed extract neutralizes the effects of Cerastes cerastes cerastes post-synaptic neurotoxin in mouse diaphragm

Cited by 9 publications

References 50 publications

Antimicrobial activity of grape seed extract on Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice

Antimicrobial activity of grape seed extract on Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice

Feeding broilers with wheat germ, hops and grape seed extract mixture improves growth performance

The Antimicrobial Activities of Silver Nanoparticles from Aqueous Extract of Grape Seeds against Pathogenic Bacteria and Fungi

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