Grape seed extract supplementation modulates hepatic lipid metabolism in rats. Implication of PPARβ/δ

Guisantes-Batán, Eduardo; Mazuecos, Lorena; Rubio, Blanca; Pereira-Caro, Gema; Moreno-Rojas, José Manuel; Andrés, Antonio; Gómez‐Alonso, Sergio; Gallardo, Nilda

doi:10.1039/d2fo02199d

Cited by 5 publications

(2 citation statements)

References 74 publications

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“…The exact mechanism of grape products on liver function is still unclear. However, previous studies showed that grapes can inhibit liver damage via peroxisome proliferator‐activated receptor gamma (PPARγ) (Guisantes‐Batan et al, 2022). The inactivation of PPAR in hepatocytes is associated with an increase in body and liver weight, as well as a decrease in serum AST levels (Mirzaii et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Alhajlah

2024

Phytotherapy Research

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In recent years, an increase in the incidence of liver diseases has been reported all over the world. This study aims to comprehensively summarize and quantitatively analyze the existing evidence concerning the effectiveness of grape‐derived products on liver enzymes through a systematic review and meta‐analytic approach. PubMed, Scopus, Cochrane Library, and ISI Web of Science were comprehensively searched until January 2024. Articles that reported the effect of grape‐derived products on serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels were included. Weighted mean differences (WMDs) were pooled using a random‐effects model. Nine studies were included in the meta‐analysis. The results revealed that grape‐derived products did not significantly change the concentrations of ALT (WMD: −2.70 IU/L, 95% CI: −6.14 to 0.75, p = 0.12), and AST (WMD: ‐1.42 IU/L, 95% CI: −3.54 to 0.70, p = 0.18). However, a significant reduction was observed in serum ALP levels (WMD: ‐5.49 IU/L, 95% CI: −9.57 to −1.4, p = 0.008). The present findings suggest that grape‐derived products positively influence serum ALP levels among adults. However, a more comprehensive decision necessitates additional studies.

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Section: Discussionmentioning

confidence: 99%

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Alhajlah

2024

Phytotherapy Research

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“…Furthermore, the hepatoprotective role of GSE was suggested based on the results from an in vivo rat NAFLD model, whereby GSE was found to be more effective than metformin [180]. The PPARγ-dependent modulation of hepatic lipid metabolism might be one mechanism underlying the protective effects of GSE on metabolic parameters [188].…”

Section: Vitis Viniferamentioning

confidence: 99%

Targeting Metabolic Syndrome in Hidradenitis Suppurativa by Phytochemicals as a Potential Complementary Therapeutic Strategy

Witte,

Wolk,

Witte-Händel

et al. 2023

Nutrients

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by the appearance of painful inflamed nodules, abscesses, and pus-draining sinus tracts in the intertriginous skin of the groins, buttocks, and perianal and axillary regions. Despite its high prevalence of ~0.4–1%, therapeutic options for HS are still limited. Over the past 10 years, it has become clear that HS is a systemic disease, associated with various comorbidities, including metabolic syndrome (MetS) and its sequelae. Accordingly, the life expectancy of HS patients is significantly reduced. MetS, in particular, obesity, can support sustained inflammation and thereby exacerbate skin manifestations and the chronification of HS. However, MetS actually lacks necessary attention in HS therapy, underlining the high medical need for novel therapeutic options. This review directs attention towards the relevance of MetS in HS and evaluates the potential of phytomedical drug candidates to alleviate its components. It starts by describing key facts about HS, the specifics of metabolic alterations in HS patients, and mechanisms by which obesity may exacerbate HS skin alterations. Then, the results from the preclinical studies with phytochemicals on MetS parameters are evaluated and the outcomes of respective randomized controlled clinical trials in healthy people and patients without HS are presented.

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PPARβ/δ as a promising molecular drug target for liver diseases: A focused review

Meng,

Wang,

et al. 2024

Clinics and Research in Hepatology and Gastroenterology

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Grape seed extract supplementation modulates hepatic lipid metabolism in rats. Implication of PPARβ/δ

Abstract: In mammals, the liver is involved in nutrient metabolism and the regulation of lipid and glucose homeostasis. Multiple studies have described improvements in liver disorders after regular consumption of grape...

Cited by 5 publications

References 74 publications

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Effect of grape‐derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta‐analysis of parallel randomized controlled trials

Targeting Metabolic Syndrome in Hidradenitis Suppurativa by Phytochemicals as a Potential Complementary Therapeutic Strategy

PPARβ/δ as a promising molecular drug target for liver diseases: A focused review

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