Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway

He, Xuegang; X, Guo; Ma, Zhanjun; Liu, Ying; Kang, Jihe; Zhang, Guangzhi; Gao, Yi-Cheng; Liu, Mingqiang; Chen, Haiwei; Kang, Xuewen

doi:10.1016/j.neulet.2021.135793

Cited by 23 publications

(15 citation statements)

References 38 publications

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“…Zhou et al found that proanthocyanidins could promote functional recovery following SCI by inhibiting ferroptosis [ 47 ]. Our previous study demonstrated that proanthocyanidins could inhibit H 2 O 2 -induced apoptosis in PC12 cells [ 48 ]. Nonetheless, to date, no study has evaluated the potential effects of proanthocyanidins on microglial polarisation following SCI.…”

Section: Discussionmentioning

confidence: 99%

Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury

Liu

Kang

et al. 2022

Mediators of Inflammation

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Spinal cord injury (SCI) is a highly disabling disorder for which few effective treatments are available. Grape seed proanthocyanidins (GSPs) are polyphenolic compounds with various biological activities. In our preliminary experiment, GSP promoted functional recovery in rats with SCI, but the mechanism remains unclear. Therefore, we explored the protective effects of GSP on SCI and its possible underlying mechanisms. We found that GSP promoted locomotor recovery, reduced neuronal apoptosis, increased neuronal preservation, and regulated microglial polarisation in vivo. We also performed in vitro studies to verify the effects of GSP on neuronal protection and microglial polarisation and their potential mechanisms. We found that GSP regulated microglial polarisation and inhibited apoptosis in PC12 cells induced by M1-BV2 cells through the Toll-like receptor 4- (TLR4-) mediated nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinase/serine threonine kinase (PI3K/AKT) signaling pathways. This suggests that GSP regulates microglial polarisation and prevents neuronal apoptosis, possibly by the TLR4-mediated NF-κB and PI3K/AKT signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury

Liu

Kang

et al. 2022

Mediators of Inflammation

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“…Proanthocyanidins play a central role in wine grapes because of their physiological and oenological significance (Li et al, 2021). In the analysis of proanthocyanidins, the relative content of proanthocyanidins in Cabernet Sauvignon peel was significantly increased after ferric citrate treatment, which may be that the oxidation of ferric citrate promotes the synthesis of Cabernet Sauvignon procyanidins (He et al, 2021). However, ferrous sulfate and ferric sugar alcohol have weak oxidizing properties, and the improvement of proanthocyanidins is not obvious.…”

Section: Discussionmentioning

confidence: 99%

Effects of foliar iron spraying on Cabernet Sauvignon phenolic acids and proanthocyanidins

WANG

et al. 2022

Food Sci. Technol

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In order to explore the effect of different irons on the fruit quality of wine grapes, as well as the phenolic acids and proanthocyanidins of the peel, "Cabernet Sauvignon" was taken as the research object. Ferrous sulfate, EDTA-Fe, ferric citrate, ferric gluconate and ferric sugar alcohol were sprayed between the coloring periods, and the foliar sprayed water was used as the control. The results showed that foliar spraying of iron would increase the fruit sugar-acid ratio and 100-grain weight; iron spraying would up-regulate the content of phenolic acid monomers, among which EDTA-Fe and ferric citrate had significant up-regulating effects, but all iron treatments had a significant effect on the increase. The content of caffeic acid and chlorogenic acid was down-regulated; the content of proanthocyanidin monomer was up-regulated by iron spraying, and the content of proanthocyanidin monomer was significantly up-regulated by ferric citrate treatment. Foliar spraying of ferric citrate not only balanced the sugar-acid ratio of the fruit, but also increased the content of phenolic acid and proanthocyanidin in the grape peel, which further improved the quality of the grapes and helped to increase the flavor of the wine.

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“…Proanthocyanidins have been reported to play an important role in the antioxidant activity of grape. A cell study by He et al showed that grape seed proanthocyanidins protected PC12 cells from oxidative injury induced by H 2 O 2 via the phosphoinositide 3-kinase (PI3K)/serine-threonine kinase (Akt) signaling pathway [ 44 ]. In addition, grape seed proanthocyanidin extract ameliorated varicocele-induced testicular oxidative damage in rats by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway [ 45 ].…”

Section: Health Benefits Of Grapementioning

confidence: 99%

Bioactive Compounds, Health Benefits and Food Applications of Grape

Zhou

Xiong

et al. 2022

Foods

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Grape (Vitis vinifera L.) is one of the most popular fruits worldwide. It contains various bioactive compounds, such as proanthocyanidins, anthocyanins, flavonols, phenolic acids and stilbenes, the contents of which could vary considerably in grape skin, pulp and seed. Many studies have revealed that grape possesses a variety of health benefits, such as antioxidant, anti-inflammatory, gut-microbiota-modulating, anticancer and cardioprotective effects. Grape is eaten as fresh fruit and is also used as raw material to produce various products, such as wine, grape juice and raisins. Moreover, the byproducts of grape, such as grape pomace and grape seed, have many applications in the food industry. In this paper, the bioactive compounds in grape are briefly summarized based on literature published in recent years. In addition, the health benefits of grape and its bioactive components are discussed, with special attention paid to the underlying mechanisms. Furthermore, the applications of grape in the food industry are elucidated, especially the applications of grape pomace and grape seed. This paper can contribute to understanding the health benefits and mechanisms of grape and its bioactive compounds, as well as the promotion of the use of grape in the food industry.

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Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway

Cited by 23 publications

References 38 publications

Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury

Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury

Effects of foliar iron spraying on Cabernet Sauvignon phenolic acids and proanthocyanidins

Bioactive Compounds, Health Benefits and Food Applications of Grape

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