Grape skin extract-derived polyphenols modify programming-induced renal endowment in prenatal protein-restricted male mouse offspring

Costa, Mariana Ribeiro; Pires, Karla Maria Pereira; Nalbones-Barbosa, Mariane Nogueira; Valença, Samuel dos Santos; Resende, Ângela Castro; Moura, Roberto Soares de

doi:10.1007/s00394-015-0963-5

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…Similar effects have been found with soy genistein-rich diets; specifically decreased oxidative stress and beneficial effects on the cardiovascular system, lowering incidence of hypertension [ 104 ]. The stilbene resveratrol has comparable positive effects on oxidative stress and metabolism in adults [ 105 , 106 ] and there is experimental evidence that ameliorates embryonic oxidative stress and apoptosis associated with diabetic embryopathy, preventing developmental delays in embryos of diabetic dams and, afterwards, glomerular loss and renal immaturity in fetuses [ 107 , 108 , 109 , 110 ].…”

Section: Polyphenols and In Vivo Reproductive Eventsmentioning

confidence: 99%

Polyphenols in Farm Animals: Source of Reproductive Gain or Waste?

2020

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Reproduction is a complex process that is substantially affected by environmental cues, specifically feed/diet and its components. Farm animals as herbivorous animals are exposed to a large amount of polyphenols present in their natural feeding system, in alternative feed resources (shrubs, trees, and agro-industrial byproducts), and in polyphenol-enriched additives. Such exposure has increased because of the well-known antioxidant properties of polyphenols. However, to date, the argumentation around the impacts of polyphenols on reproductive events is debatable. Accordingly, the intensive inclusion of polyphenols in the diets of breeding animals and in media for assisted reproductive techniques needs further investigation, avoiding any source of reproductive waste and achieving maximum benefits. This review illustrates recent findings connecting dietary polyphenols consumption from different sources (conventional and unconventional feeds) with the reproductive performance of farm animals, underpinned by the findings of in vitro studies in this field. This update will help in formulating proper diets, optimizing the introduction of new plant species, and feed additives for improving reproductive function, avoiding possible reproductive wastes and maximizing possible benefits.

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Section: Polyphenols and In Vivo Reproductive Eventsmentioning

confidence: 99%

Polyphenols in Farm Animals: Source of Reproductive Gain or Waste?

2020

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“…On each experiment day, the pigs received a single dose of one of two treatments: red cabbage or grape skin extracts at one of four doses: 0, 2.22, 4.44, and 11.11 mg GAE/kg BW. Considering that the grape skin extract had a higher total phenolic content compared to the red cabbage extract, the doses were selected based on previous studies of grape skin extract administered safely to mice [ 49 , 50 , 51 ]. The maximal dose of 11.11 mg GAE/kg BW corresponding to 30 mg grape skin extract/kg BW was selected for our pig study, as this dose is equivalent to the proven safe dose of 200 mg grape skin extract/kg BW in mice [ 52 ].…”

Section: Methodsmentioning

confidence: 99%

Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model

et al. 2017

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Phytochemical-rich diets are protective against chronic diseases and mediate their protective effect by regulation of oxidative stress (OS). However, it is proposed that under some circumstances, phytochemicals can promote production of reactive oxygen species (ROS) in vitro, which might drive OS-mediated signalling. Here, we investigated the effects of administering single doses of extracts of red cabbage and grape skin to pigs. Blood samples taken at baseline and 30 min intervals for 4 hours following intake were analyzed by measures of antioxidant status in plasma, including Trolox equivalent antioxidant capacity (TEAC) and glutathione peroxidase (GPx) activity. In addition, dose-dependent production of hydrogen peroxide (H2O2) by the same extracts was measured in untreated commercial pig plasma in vitro. Plasma from treated pigs showed extract dose-dependent increases in non-enzymatic (plasma TEAC) and enzymatic (GPx) antioxidant capacities. Similarly, extract dose-dependent increases in H2O2 were observed in commercial pig plasma in vitro. The antioxidant responses to extracts by treated pigs were highly correlated with their respective yields of H2O2 production in vitro. These results support that dietary phytochemicals regulate OS via direct and indirect antioxidant mechanisms. The latter may be attributed to the ability to produce H2O2 and to thereby stimulate cellular antioxidant defence systems.

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“…Oxidative stress and inflammation are major contributors to vascular remodeling and hypertension ( 106 ). In LP ( 94 , 107 ) and maternal smoking models ( 108 ), it was shown that oxidative stress during critical developmental steps may significantly contribute to renal susceptibility toward disease. In addition, both IUGR offspring after global undernutrition of the dam ( 109 ) and after high-fat died during gestation and lactation ( 110 ) showed increased oxidative stress and elevated blood pressure later in life.…”

Section: Mechanisms Of Renal Programmingmentioning

confidence: 99%

Developmental Programming of Renal Function and Re-Programming Approaches

et al. 2018

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Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life. This mini-review discusses critical developmental periods and long-term sequelae of renal programming in humans and presents studies examining the underlying mechanisms as well as interventional approaches to “re-program” renal susceptibility toward disease. Clinical manifestations of programmed kidney disease include arterial hypertension, proteinuria, aggravation of inflammatory glomerular disease, and loss of kidney function. Nephron number, regulation of the renin–angiotensin–aldosterone system, renal sodium transport, vasomotor and endothelial function, myogenic response, and tubuloglomerular feedback have been identified as being vulnerable to environmental factors. Oxidative stress levels, metabolic pathways, including insulin, leptin, steroids, and arachidonic acid, DNA methylation, and histone configuration may be significantly altered by adverse environmental conditions. Studies on re-programming interventions focused on dietary or anti-oxidative approaches so far. Further studies that broaden our understanding of renal programming mechanisms are needed to ultimately develop preventive strategies. Targeted re-programming interventions in animal models focusing on known mechanisms will contribute to new concepts which finally will have to be translated to human application. Early nutritional concepts with specific modifications in macro- or micronutrients are among the most promising approaches to improve future renal health.

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Grape skin extract-derived polyphenols modify programming-induced renal endowment in prenatal protein-restricted male mouse offspring

Abstract: The treatment of low-protein-fed dams during pregnancy with ACH09 provides protection from early-life deleterious renal morphological changes. The protective effect of ACH09 may involve antioxidant action and vasodilator effect of the extract.

Cited by 13 publications

References 36 publications

Polyphenols in Farm Animals: Source of Reproductive Gain or Waste?

Polyphenols in Farm Animals: Source of Reproductive Gain or Waste?

Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model

Developmental Programming of Renal Function and Re-Programming Approaches

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