The mixture of data in real life exhibits structure or connection property in nature. Typical data include biological data, communication network data, image data, etc. Graphs provide a natural way to represent and analyze these types of data and their relationships. For instance, more recently, graphs have found new applications in solving problems for emerging research fields such as social network analysis, design of robust computer network topologies, frequency allocation in wireless networks, and bioinformatics. Unfortunately, the related algorithms usually suffer from high computational complexity, since some of these problems are NP-hard. Therefore, in recent years, many graph models and optimization algorithms have been proposed to achieve a better balance between efficacy and efficiency. The aim of this Special Issue is to provide an opportunity for researchers and engineers from both academia and the industry to publish their latest and original results on graph models, algorithms, and applications to problems in the real world, with a focus on optimization and computational complexity.