Graphene-based materials: A new tool to fight against breast cancer

Zheng, Jifang; Meng, Dandan; Zheng, Xiaohui; Zhang, Yan; Chen, Hongfei

doi:10.1016/j.ijpharm.2021.120644

Cited by 22 publications

(10 citation statements)

References 136 publications

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“…These results indicated that depending on the application, fabricating a carrier that can diffuse the mentioned barriers to reach the targeted site of the body raises the demand for achieving a uniform size of GO particles using the mentioned approaches. In addition, different sizes of functionalized GO have been utilized for breast cancer therapy [ 17 , 51 , 53 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ].…”

Section: Characteristics Of Go As a Nanocarriermentioning

confidence: 99%

“…Numerous studies have analyzed characteristics of GO to determine its potential use for biomedical applications [ 69 , 117 , 118 ]. These studies have shown that the toxicity depends on the complex interactions of several intrinsic characteristics of GO and extrinsic factors.…”

Section: Toxicitymentioning

confidence: 99%

“…These studies have shown that the toxicity depends on the complex interactions of several intrinsic characteristics of GO and extrinsic factors. The physiochemical properties, such as the shape, size, oxidation, and functionalization [ 69 , 119 , 120 ], are some of the main characteristics of GOs that can influence their interaction with the biological system. In addition, other experimental parameters, such as the dose of administration, time of exposure of GOs to cells, and type of cell line, represent important discriminating factors that can result in variable toxicity responses [ 118 , 119 , 121 ].…”

Section: Toxicitymentioning

confidence: 99%

“…Therefore, the functionalization of the nanocarriers with targeting molecules (e.g., antibodies specific to certain cells) is the main approach to control the accumulation and exposure time of the nanomaterials to specific sites. Targeting molecules, which can specifically recognize the tumoral cells, allow nanoparticles to accumulate in the cancer site, inducing the cytotoxic effect mainly only in the circumscribed area of the tumor [ 69 ]. In addition, functionalization can increase the specificity and recognition potential of the nanocarriers from the body [ 137 ].…”

Section: Toxicitymentioning

confidence: 99%

“…Moreover, even if it has been reported that the cell internalization of GO is size-dependent in different cell lines [ 52 , 53 ], different studies have proven that macrophages (i.e., PMƟ and J774A.1) are not always affected by the size and dosage during GO uptake [ 117 ]. All of these findings may demonstrate the potential for naked graphene-based materials to be degraded within phagocytic cells after the payload delivery [ 69 , 123 ].…”

Section: Toxicitymentioning

confidence: 99%

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Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells

Grilli

Gohari

Zou

2022

IJMS

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Functionalized graphene oxide (GO) nanoparticles are being increasingly employed for designing modern drug delivery systems because of their high degree of functionalization, high surface area with exceptional loading capacity, and tunable dimensions. With intelligent controlled release and gene silencing capability, GO is an effective nanocarrier that permits the targeted delivery of small drug molecules, antibodies, nucleic acids, and peptides to the liquid or solid tumor sites. However, the toxicity and biocompatibility of GO-based formulations should be evaluated, as these nanomaterials may introduce aggregations or may accumulate in normal tissues while targeting tumors or malignant cells. These side effects may potentially be impacted by the dosage, exposure time, flake size, shape, functional groups, and surface charges. In this review, the strategies to deliver the nucleic acid via the functionalization of GO flakes are summarized to describe the specific targeting of liquid and solid breast tumors. In addition, we describe the current approaches aimed at optimizing the controlled release towards a reduction in GO accumulation in non-specific tissues in terms of the cytotoxicity while maximizing the drug efficacy. Finally, the challenges and future research perspectives are briefly discussed.

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Section: Characteristics Of Go As a Nanocarriermentioning

confidence: 99%

Section: Toxicitymentioning

confidence: 99%

Section: Toxicitymentioning

confidence: 99%

Section: Toxicitymentioning

confidence: 99%

Section: Toxicitymentioning

confidence: 99%

See 3 more Smart Citations

Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells

Grilli

Gohari

Zou

2022

IJMS

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Theranostic Approach of 2D Nanomaterials in Breast Cancer

Panda,

Chakroborty,

Pal

2024

2D Nanomaterials

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Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release

You

Guo

et al. 2022

ChemistrySelect

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Graphene oxide (GO) and its derivatives are considered as a promising drug carrier in tumor therapy due to their excellent biocompatibility. Here, a series of nanostructured GO with long‐range ordered lamellar or hexagonal structure were prepared by lyotropic liquid crystals (LLCs) templating strategy and used as drug carriers. The nanostructure was verified via polarized‐light optical microscopy (POM), low angle X‐ray diffraction (XRD) and transmission electron microscopy (TEM), which showed that the interlayer spacing or pore size was determined by the carbon chain length of templating molecular. 5‐fluorouracil (5‐Fu), doxorubicin (DOX) and docetaxel (DOC) which had gradually increased molecular size were chosen as model drugs, and the highly ordered nanochannels can be used as space for adsorption and diffusion of drug molecules. Ultraviolet spectrometer and simulated release test in vitro were used to determine drug loading capacity and drug release performance. The results showed that larger pore diameter/layer spacing was beneficial to the adsorption and diffusion of drug molecules, especially those with shorter molecule size. Besides, the water‐solvable DOX exhibited fast release rate than the hydrophobic 5‐Fu and DOC. The in vitro cytotoxicity assay demonstrated the good biocompatibility of both the pristine GO and the nanostructured GO.

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Graphene-based materials: A new tool to fight against breast cancer

Cited by 22 publications

References 136 publications

Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells

Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells

Theranostic Approach of 2D Nanomaterials in Breast Cancer

Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release

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