Graphene-encapsulated iron nanoparticles as a non-viral vector for gene delivery into melanoma cells

Bamburowicz-Klimkowska, Magdalena; Małecki, Maciej; Bystrzejewski, M.; Kasprzak, Artur; Grudziński, Ireneusz P.

doi:10.1016/j.bbrc.2023.02.042

Cited by 9 publications

(1 citation statement)

References 37 publications

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“…More recently, Bamburowicz-Klimkowska et al [ 169 ] synthesized next-generation NMs graphene encapsulated magnetic NPs (GEMNs) for the delivery of genes into melanoma cells. In this study, a green fluorescence protein expression plasmid DNA (pDNA) was employed and GEMNs were decorated with branched polyethyleneimine (PEI) to synthesize nanotransporter (GEMNS-PEI/pDNA.…”

Section: Classification Of Nanomaterialsmentioning

confidence: 99%

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Parhi,

Kaishap,

Jena

2023

ADMET DMPK

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Background and Purpose: Safe and effective drug delivery is crucial for the treatment of cancer, which is quite impossible to achieve through traditional methods. Among all types of cancer, skin melanoma is known for its aggressive metastasizing ability and an unprecedented higher degree of lethalness, limiting the overall therapeutic efficacy. Here, we focus on the different types of nanomaterials (NMs) and their drug delivery applications against melanoma. Experimental Approach: All relevant publications, including research papers, reviews, chapters and patents, were assessed using search engines such as Scopus and PubMed, up to the end of August of 2023. The keywords used in the search were: nanomaterials, melanoma, drug delivery routes for melanoma, and nanomaterial-based drug delivery systems (DDS). Most of the publications out of 234 cited in this review are from the last five years. Key Results: The recent advancement and mechanism of action of various NMs against melanoma, including inorganic metallic and carbon-based NMs, organic polymeric and lipid-based NMs, and cell-derived vesicles are discussed. We also focus on the application of different NMs in the delivery of therapeutic agents for melanoma therapy. In addition, the skin and melanoma, genetic mutation and pathways for melanoma, conventional treatment options, and delivery routes for therapeutic agents are also discussed briefly. Conclusion: There are few NM-based DDS developed in the lab set up recently. The findings of this review will pave the path for the development of NM-based DDS on an industrial scale and help in the better management of skin melanoma.

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Section: Classification Of Nanomaterialsmentioning

confidence: 99%

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Parhi,

Kaishap,

Jena

2023

ADMET DMPK

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Graphene‐Based Nanomaterials are a Potent and Innovative Technology for the Treatment of Cancer: A Review

Muzammal,

Awan,

Mukhtar

et al. 2024

ChemistrySelect

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Cancer is prevailing around the world and so does its mortality rates. Conventionally used therapies have some adverse effects as they are not entirely accurate, leading researchers and investigators to explore new ways and materials. They are constantly looking into ways that can effectively cure this malicious disease and in this effort, they came across new smart materials labeled as nanoparticles (NPs). In between various sorts of nanoparticles, only graphene‐based nanomaterials (GBNMs) shine because of their particular chemical structure and properties. They have high drug loading capacity, can easily target specific tissues, and can be easily functionalized according to the stage and other factors for a patient. Several researches and trials have been executed on animal models to check the potency of these nanoparticles proving them revolutionary in the medical domain, especially for combating cancer. Through this review, we evaluate the experiments conducted by scientists in an effort to devise a platform based on graphene nanoparticles for curing cancer efficiently by using single or multiple therapeutic approaches.

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Current Developments in Some Applications of Graphene

2024

Graphene

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Graphene-encapsulated iron nanoparticles as a non-viral vector for gene delivery into melanoma cells

Cited by 9 publications

References 37 publications

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Graphene‐Based Nanomaterials are a Potent and Innovative Technology for the Treatment of Cancer: A Review

Current Developments in Some Applications of Graphene

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