2016
DOI: 10.1371/journal.pone.0151589
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Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain

Abstract: Electroactive materials have been investigated as next-generation neuronal tissue engineering scaffolds to enhance neuronal regeneration and functional recovery after brain injury. Graphene, an emerging neuronal scaffold material with charge transfer properties, has shown promising results for neuronal cell survival and differentiation in vitro. In this in vivo work, electrospun microfiber scaffolds coated with self-assembled colloidal graphene, were implanted into the striatum or into the subventricular zone … Show more

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Cited by 80 publications
(73 citation statements)
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“…Therefore, combining graphene substrate and rTMS exposure could be a promising candidate for complementary therapy that facilitates self‐repairing capabilities when stem cells grown on graphene were injected to injured tissue. The biocompatible graphene implants combined with rTMS therapy may be applied in neuronal and neurodegenerative diseases such as Parkinson's diseases, Alzheimer's diseases, spinal cord injury, multiple sclerosis, motor neuron disorder, and neuronal stimulation after brain ischemia …”
Section: Discussionmentioning
confidence: 99%
“…Therefore, combining graphene substrate and rTMS exposure could be a promising candidate for complementary therapy that facilitates self‐repairing capabilities when stem cells grown on graphene were injected to injured tissue. The biocompatible graphene implants combined with rTMS therapy may be applied in neuronal and neurodegenerative diseases such as Parkinson's diseases, Alzheimer's diseases, spinal cord injury, multiple sclerosis, motor neuron disorder, and neuronal stimulation after brain ischemia …”
Section: Discussionmentioning
confidence: 99%
“…Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated for their potential applications in tissue engineering and regenerative medicine (Novoselov et al, 2004; John et al, 2015; Marchesan et al, 2015, 2016; Defterali et al, 2016; Lopez-Dolado et al, 2016; Zhou et al, 2016). In fact, scaffolds that support neural growth can be made of porous foams and membranes alone or loaded with a variety of GBNs and CNTs (Ramanathan et al, 2008; Chao et al, 2010; Alvarez et al, 2013; Li et al, 2013; Shah et al, 2014; Song et al, 2014; Weaver and Cui, 2015; Akhavan et al, 2016; Guo et al, 2016b,c).…”
Section: Introductionmentioning
confidence: 99%
“…; Zhou et al . ). Artificial scaffolds support not only migration, but also the survival and differentiation processes of the new neurons, and these effects are promising for promoting endogenous neuronal regeneration.…”
Section: Enhancement Of Neuronal Migration In Clinical Applicationsmentioning
confidence: 97%