Graphene oxide based FRET probe for mast cell degranulation

Tang, Shuzhen; Xu, Jianshu; Lin, Yating; Zheng, Mengmeng; Lin, Yamin; Huang, Yimei; Xie, Shusen; Lin, Juqiang

doi:10.1117/12.2537508

Optics in Health Care and Biomedical Optics IX 2019

DOI: 10.1117/12.2537508

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Graphene oxide based FRET probe for mast cell degranulation

Shuzhen Tang

Jianshu Xu

Yating Lin

et al.

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2020

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“…The nature of fluorescence property of fluorophores, such as quantum dots and organic dyes, basically quenches by GO through the Fluorescence Resonance Energy Transfer (FRET) 31,32 . According to recent findings, quencher GO possesses a large number of bonding sites through oxygen-containing groups, which is ideal for targeting and delivery purposes 33,34 .…”

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confidence: 99%

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Esmaeili

Bidram

Zarrabi

et al. 2020

Sci Rep

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Intrinsic fluorescence and versatile optical properties of Graphene Oxide (GO) in visible and near-infrared range introduce this nanomaterial as a promising candidate for numerous clinical applications for early-diagnose of diseases. Despite recent progresses in the impact of major features of GO on the photoluminescence properties of GO, their modifications have not yet systematically understood. Here, to study the modification effects on the fluorescence behavior, poly ethylene glycol (PEG) polymer, metal nanoparticles (Au and Fe3O4) and folic acid (FA) molecules were used to functionalize the GO surface. The fluorescence performances in different environments (water, DMEM cell media and phosphate buffer with two different pH values) were assessed through fluorescence spectroscopy and fluorescent microscopy, while Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) and Scanning electron microscopy (SEM) were utilized to evaluate the modifications of chemical structures. The modification of GO with desired molecules improved the photoluminescence property. The synthesized platforms of GO-PEG, GO-PEG-Au, GO-PEG-Fe3O4 and GO-PEG-FA illustrated emissions in three main fluorescence regions (blue, green and red), suitable for tracing and bio-imaging purposes. Considering MTT results, these platforms potentially positioned themselves as non-invasive optical sensors for the diagnosis alternatives of traditional imaging agents.

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mentioning

confidence: 99%

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Esmaeili

Bidram

Zarrabi

et al. 2020

Sci Rep

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Graphene oxide based FRET probe for mast cell degranulation

Cited by 1 publication

References 11 publications

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

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