Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

Dorniani, Dena; Saifullah, Bullo; Barahuie, Farahnaz; Arulselvan, Palanisamy; Hussein, Mohd Zobir; Fakurazi, Sharida; Twyman, Lance J.

doi:10.1186/s11671-016-1712-2

Cited by 81 publications

(51 citation statements)

References 55 publications

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“…The nanodrug delivery platform is a subject of rapid growth because of its significant role in the improvement of therapeutic values of different drugs and bioactive molecules by modulating their release profiles, bioavailability, and solubility, and protecting the drug from degradation [ 5 , 12 , 13 ]. Increased efforts are now being invested into engineering multifunctional, biocompatible nanomaterials for the delivery of drugs at the site of infection thereby resulting in more effective therapy [ 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Anti-Tuberculosis Nanodelivery Formulation of Ethambutol with Graphene Oxide

et al. 2017

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Tuberculosis (TB) is a bacterial disease responsible for millions of infections and preventable deaths each year. Its treatment is complicated by patients’ noncompliance due to dosing frequency, lengthy treatment, and adverse side effects associated with current chemotherapy. However, no modifications to the half-a-century old standard chemotherapy have been made based on a nanoformulation strategy to improve pharmacokinetic efficacy. In this study, we have designed a new nanodelivery formulation, using graphene oxide as the nanocarrier, loaded with the anti-TB antibiotic, ethambutol. The designed formulation was characterized using a number of molecular analytical techniques. It was found that sustained release of the drug resulted in better bioavailability. In addition, the designed formulation demonstrated high biocompatibility with mouse fibroblast cells. The anti-TB activity of the nanodelivery formulation was determined using whole-cell resazurin microtiter plate assay, modified-spot culture growth inhibition assay, and biofilm inhibition assay. The nanodelivery formulation showed good anti-mycobacterial activity. The anti-mycobacterial activity of Ethambutol was unaffected by the drug loading and release process. The results of this study demonstrated the potential of this new nanodelivery formulation strategy to be considered for modifying existing chemotherapy to yield more efficacious antibiotic treatment against TB.

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Section: Introductionmentioning

confidence: 99%

Novel Anti-Tuberculosis Nanodelivery Formulation of Ethambutol with Graphene Oxide

et al. 2017

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“…Additionally, the burst effect that presence in the graph of the Na3PO3 solution may occur due to the surface characteristics of a graphite oxide material, the herbicide interactions and porous structure of the material [9]. The characteristics of the mechanism of the ion-exchange method would not lead the percentage of MCPA anion released from MCPA-GO nanocomposite at equilibrium reach 100%.…”

Section: Controlled Release Studiesmentioning

confidence: 99%

“…It is because they are facilitating the good targeting, high loading and control release of drugs/herbicides. By exploring the area drugs delivery system, Barahuie et al [8] have reported the graphite oxide as a nanocarrier for the active anticancer agent of chlorogenic acid while Dorniani et al [9], makes their research on gallic acid as a cancer therapy by using the graphite oxide too. Besides that, Yu et al [10] did some modification in their work to make the graphite oxide being able to be as a nanocarrier loaded with anticancer herbal drug berberine by combined the graphite oxide with PEG.…”

Section: ■ Introductionmentioning

confidence: 99%

Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite

et al. 2020

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In this present work, herbicide named 2-methyl-4-chlorophenoxy acetic acid (MCPA) was intercalated into the graphite oxide through ion-exchange method to produce an MCPA-GO nanocomposite as an herbicide delivery system. The formation of MCPA-GO nanocomposite was confirmed by using PXRD, Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), UV-Visible Spectroscopy and Accelerated Surface Area Surface (ASAP). As for PXRD pattern, there was increasing in the basal spacing of the nanocomposite from the graphite oxide which by 9.3 to 9.7 Å indicated that MCPA has successfully inserted into the interlayers of the graphite oxide. Meanwhile, the FTIR spectrum showed the appearance of a new peak in MCPA-GO nanocomposite at 1308 cm -1 represents the functional group of carboxylate (COO -). This peak is very necessary for the confirmation of the anionic form of MCPA inserted into the interlayers of graphite oxide. The controlled release property was also done for further investigation by using various aqueous media to determine the percentage release of MCPA from the nanocomposite. The percentage of herbicide release in Na3PO3 solution was higher than in Na2CO3 and NaCl solution proved that the release properties exhibit the potential application of graphite oxide as effective nanocarrier of herbicides. MCPA-GO nanocomposite suggested being most promising herbicide since it can lower the toxicity of precursor MCPA, high biocompatibility, and more efficient in herbicide delivery system.

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“…These groups suggest the presence of AuNPs. 28,29 TeM and eDX analysis of auNPs synthesized from sx TEM imaging uses a narrow beam of electrons focused on the sample and measures the size of the particle accurately. TEM images showed AuNPs as dark spots against a light background.…”

Section: Ftir Analysis Of Aunps Synthesized From Sxmentioning

confidence: 99%

Synthesis of gold nanoparticles with <em>Solanum xanthocarpum</em> extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells

Zhang

Wang

Liu³

et al. 2018

IJN

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BackgroundNasopharyngeal cancer (NPC) is one of the subtypes of head and neck cancers. It occurs rarely, and its prevalence depends mainly on geographical location. Modern-day research is focused on coupling nanotechnology and traditional medicine for combating cancers. Gold nanoparticles (AuNPs) were synthesized from Solanum xanthocarpum (Sx) leaf extract using reduction method.MethodsCharacterization of the synthesized AuNPs was done by different techniques such as ultraviolet–visible spectrum absorption, X-ray diffraction, dynamic light scattering, Fourier transform infrared spectroscopy, transmission electron microscopy, and energy-dispersive X-ray analysis.ResultsAll the results showed the successful green synthesis of AuNPs from Sx, which induced apoptosis of C666-1 cell line (NPC cell line). There was a decline in both cell viability and colony formation in C666-1 cells upon treatment with Sx-AuNPs. The cell death was proved to be caused by autophagy and mitochondrial-dependent apoptotic pathway.ConclusionThus, due to their anticancer potential, these nanoparticles coupled with Sx can be used for in vivo applications and clinical research in future.

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Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

Cited by 81 publications

References 55 publications

Novel Anti-Tuberculosis Nanodelivery Formulation of Ethambutol with Graphene Oxide

Novel Anti-Tuberculosis Nanodelivery Formulation of Ethambutol with Graphene Oxide

Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite

Synthesis of gold nanoparticles with <em>Solanum xanthocarpum</em> extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells

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