Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy

Jin, Yushen; Wang, Jinrui; Ke, Hengte; Wang, Shumin; Dai, Zhifei

doi:10.1016/j.biomaterials.2013.03.027

Cited by 185 publications

(136 citation statements)

References 25 publications

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“…For this reason, GO and RGO are considered favorable in the formulation of devices and sensorsaddressing living matter, such as electro-optic modulators, fluorescence-sensors, and laser absorption medium. [8][9][10][11] In contrast, pristine graphene has received limited attention in these fields, compared to its derivatives, due to the absence of functional groups on its surface for use for further derivatization. However, the peculiar almost wavelength independent spectral absorption of pristine graphene, extending from the visible to near Infrared (NIR), as well as its efficient photo-acoustic conversion, has recently been considered an asset for improving biomedical imaging, especially for the emerging photoacoustic imaging (PAI) modalities.…”

Section: Introductionmentioning

confidence: 95%

Graphene Meets Microbubbles: A Superior Contrast Agent for Photoacoustic Imaging

Toumia

Domenici

Orlanducci

et al. 2016

ACS Appl. Mater. Interfaces

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Coupling graphene with a soft polymer surface offers the possibility to build hybrid constructs with new electrical, optical, and mechanical properties. However, the low reactivity of graphene is a hurdle in the synthesis of such systems which is often bypassed by oxidizing its carbon planar structure. However, the defects introduced with this process jeopardize the properties of graphene. In this paper we present a different approach, applicable to many different polymer surfaces, which uses surfactant assisted ultrasonication to exfoliate, and simultaneously suspend, graphene in water in its intact form. Tethering pristine graphene sheets to the surfaces is accomplished by using suitable reactive functional groups of the surfactant scaffold. We focused on applying this approach to the fabrication of a hybrid system, made of pristine graphene tethered to poly(vinyl alcohol) based microbubbles (PVA MBs), designed for enhancing photoacoustic signals. Photoacoustic imaging (PAI) is a powerful preclinical diagnostic tool which provides real time images at a resolution of 40 μm. The leap toward clinical imaging has so far been hindered by the limited tissues penetration of near-infrared (NIR) pulsed laser radiation. Many academic and industrial research laboratories have met this challenge by designing devices, each with pros and cons, to enhance the photoacoustic (PA) signal. The major advantages of the hybrid graphene/PVA MBs construct, however, are (i) the preservation of graphene properties, (ii) biocompatibility, a consequence of the robust anchoring of pristine graphene to the bioinert surface of the PVA bubble, and (iii) a very good enhancement in a NIR spectral region of the PA signal, which does not overlap with the signals of PA active endogenous molecules such as hemoglobin.

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Section: Introductionmentioning

confidence: 95%

Graphene Meets Microbubbles: A Superior Contrast Agent for Photoacoustic Imaging

Toumia

Domenici

Orlanducci

et al. 2016

ACS Appl. Mater. Interfaces

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“…The Au-PAA-GO nanocomposites were used in vivo photothermal therapy, due to the strong NIR absorption of GO, and in vivo bimodal ultrasound and computed tomography imaging, due to the enhancement of ultrasound imaging by the PAA microcapsules and the use of Au nanoparticles as contrast agent, respectively. 51 Simpler nanocomposites were developed for cancer theranostics applications with single layer RGO. 52,53 RGO were only functionalized with bovine serum albumin (BSA) and the synthesized RGO-BSA nanocomposites were used for photothermal therapy of MCF-7 cancer cells and for in vivo photoacoustic and ultrasounds imaging.…”

Section: Tumor Theranostics Applications Of Graphenementioning

confidence: 99%

Carbon Nanomaterials for Tumor Targeting Theranostics

Leitão¹,

Simões²,

Silva³

2016

Nanomaterials for Tumor Targeting Theranostics

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Carbon nanomaterials are the focus of an intense research in several areas of science. Due to their apparent low toxicity, when compared to other nanomaterials, carbon based nanoparticles found particularly important applications in biomedicine. Indeed, carbon shows many nanoallotropic forms like carbon nanotubes, graphene, carbon dots, fullerene and nanodiamonds. Some of them show fluorescence in the visible wavelength range, like graphene and carbon dots, but all have in common being nanosized with the corresponding properties. The main theranostics applications of carbon based nanomaterials (the fluorescent nanoallotropes) are for improving tumor imaging, allowing earlier detection, and specific drug delivery allowing high treatment efficient and reduced side effects. This chapter will describe the carbon nanomaterials mostly used for tumor targeting theranostics, their properties and the engineering strategies used to modify them. Also, the most successful biomedical applications of the carbon nanomaterials will be described.

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“…The particles were used to successfully image the kidney and liver of mice [101]. Jin created a microcapsule of poly(lactic acid) containing gold and graphene oxide nanoparticles [131]. Interestingly, the amount of GO increased contrast in pulse inversion harmonic mode which creates contrast by nonlinear scattering.…”

Section: Gold Nanoparticle-based Contrast Agents For Ultrasoundmentioning

confidence: 99%

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Mahan

Doiron

2018

Journal of Nanomaterials

115

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Computed tomography (CT) is among the most popular medical imaging modalities due to its high resolution images, fast scan time, low cost, and compatibility with all patients. CT scans of soft tissues require the localization of imaging contrast agents (CA) to create contrast, revealing anatomic information. Gold nanoparticles (AuNP) have attracted interest recently for their use as CT CA due to their high X-ray attenuation, simple surface chemistry, and biocompatibility. Targeting molecules may be attached to the particles to allow for the targeting of specific cell types and disease states. AuNP can also be readily designed to incorporate other imaging contrast agents such as rare earth metals and dyes. This review summarizes the current state-of-the-art knowledge in the field of AuNP used as X-ray and multimodal contrast agents. Primary research is analyzed through the lens of structure-propertyfunction to best explain the design of a particle for a given application. Design specification of particles includes size, shape, surface functionalization, composition, circulation time, and component synergy. Key considerations include delivery of a CA payload to the site of interest, nontoxicity of particle components, and contrast enhancement compared to the surrounding tissue. Examples from literature are included to illustrate the strategies used to address design considerations.

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Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy

Cited by 185 publications

References 25 publications

Graphene Meets Microbubbles: A Superior Contrast Agent for Photoacoustic Imaging

Graphene Meets Microbubbles: A Superior Contrast Agent for Photoacoustic Imaging

Carbon Nanomaterials for Tumor Targeting Theranostics

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

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