Graphene Oxide Nanoparticles as a Nonbleaching Optical Probe for Two‐Photon Luminescence Imaging and Cell Therapy

Li, Jingliang; Bao, Hongchun; Hou, Xueliang; Sun, Lu; Wang, Xun-Gai; Gu, Miṅ

doi:10.1002/anie.201106102

Cited by 200 publications

(137 citation statements)

References 27 publications

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“…The hydroxyl group is bonded with the single-crystalline GQD lattice most likely at edge sites rather than at basal plane sites. This unique edge-site functionalization could not induce any sp 3 defects within the graphene basal plane, which is different from random functionalization commonly observed in graphene oxide [42][43][44] and highly defective GQDs 2,11-13,16-23,33,34,36,37 cut from carbon materials. Their thicknesses characterized by atomic force microscope (AFM; Fig.…”

Section: Resultsmentioning

confidence: 54%

Gram-scale synthesis of single-crystalline graphene quantum dots with superior optical properties

et al. 2014

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Graphene quantum dots (GQDs) have various alluring properties and potential applications, but their large-scale applications are limited by current synthetic methods that commonly produce GQDs in small amounts. Moreover, GQDs usually exhibit polycrystalline or highly defective structures and thus poor optical properties. Here we report the gram-scale synthesis of single-crystalline GQDs by a facile molecular fusion route under mild and green hydrothermal conditions. The synthesis involves the nitration of pyrene followed by hydrothermal treatment in alkaline aqueous solutions, where alkaline species play a crucial role in tuning their size, functionalization and optical properties. The single-crystalline GQDs are bestowed with excellent optical properties such as bright excitonic fluorescence, strong excitonic absorption bands extending to the visible region, large molar extinction coefficients and long-term photostability. These high-quality GQDs can find a large array of novel applications in bioimaging, biosensing, light emitting diodes, solar cells, hydrogen production, fuel cells and supercapacitors.

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Section: Resultsmentioning

confidence: 54%

Gram-scale synthesis of single-crystalline graphene quantum dots with superior optical properties

et al. 2014

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“…Wang and Gu et al first reported transferrin functionalized GO-PEG with strong two-photon luminescence (TPL) as a nonbleaching optical probe for three-dimensional TPFI and laser-based cancer microsurgery, using an ultrafast pulsed laser as the excitation source (51). After that, Gong group developed N-GQDs as efficient two-photon fluorescent probes for cellular and deep-tissue imaging ( Fig.…”

Section: Two-photon Fluorescence Imaging (Tpfi)-two-photon Fl Imagingmentioning

confidence: 99%

Graphene-Based Nanomaterials in Bioimaging

Lin

Huang

2018

Biomedical Applications of Functionalized Nanomaterials

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“…154 They synthesized transferrin conjugated GO-PEG nanocomposites as non-bleaching imaging probes for targeted three-dimensional (3D) TPFI of the gastric cancer cell line AGS, using a low power pulsed laser for excitation. In addition to imaging, the authors also observed that the GO nanoparticles could e±ciently induce intensive microbubbling inside the cells leading to cell death at a laser power as low as 4 mW, owing to the photothermal properties of GO.…”

Section: Two Photon°uorescence Imaging (Tpfi)-guided Phototherapymentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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Graphene and graphene-based nanomaterials such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene quantum dots (GQDs) have gained a lot of attention from diverse scienti¯c¯elds for applications in sensing, catalysis, nanoelectronics, material engineering, energy storage and biomedicine due to its unique structural, optical, electrical and mechanical properties. Graphene-based nanomaterials emerge as a novel class of nanomedicine for cancer therapy for several reasons. Firstly, its structural properties like high surface area and aromaticity enables easy loading of hydrophobic drugs. Secondly, presence of oxygen containing functional groups improve its physiological stability and also act as site for biofunctionalization. Thirdly, its optical absorption in the NIR region enable them to act as photoagents for photothermal and photodynamic therapies of cancer, both in vitro and in vivo. Finally, its intrinsic°u orescence property helps in bioimaging of cancer cells. Overall, graphene-based nanomaterials can act as agents for developing multifunctional theranostic platforms for carrying out more e±cient detection and treatment of cancers. This review provides a detailed summary of the di®erent applications of graphene-based nanomaterials in drug delivery, nucleic acid delivery, phototherapy, bioimaging and theranostics.

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Graphene Oxide Nanoparticles as a Nonbleaching Optical Probe for Two‐Photon Luminescence Imaging and Cell Therapy

Cited by 200 publications

References 27 publications

Gram-scale synthesis of single-crystalline graphene quantum dots with superior optical properties

Gram-scale synthesis of single-crystalline graphene quantum dots with superior optical properties

Graphene-Based Nanomaterials in Bioimaging

Graphene-Based Nanomaterials for Theranostic Applications

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