Graphically x-ray and ultrasound diagnostics for monitnoring neoplasia of the mammary gland in bitches

Mysak, A. R.; Kiełbowicz, Zdzisław; Khomyn, N. M.; Pritsak, V. V.; Gutyj, B. V.

doi:10.15421/2018_226

Cited by 4 publications

(4 citation statements)

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“…При цьому в трьох собак, уже на етапі первинного обстеження, констатовано віддалені метастази первинного новоутворення в грудну, а в однієїодночасно у грудну і черевну порожнини. 20 Згідно результатів таких досліджень встановлено, що незалежно від використання традиційних чи цифрових рентгенівських апаратів виявити на рентгенограмах початкові фокуси метастазів (величиною до 0,5 см), практично, не вдається. І лише при досягненні ними більших розмірів, як представлено на рис.…”

Section: рентгенологічне та сонографічне дослідження неоплазійunclassified

Mammary gland neoplasias in bitches (spreading, diagnosis, treatment methods)

Mysak

Pritsak

Ivashkiv

2022

Topical Issues of the Development of Veterinary Medicine and Breeding Technologies

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Section: рентгенологічне та сонографічне дослідження неоплазійunclassified

Mammary gland neoplasias in bitches (spreading, diagnosis, treatment methods)

Mysak

Pritsak

Ivashkiv

2022

Topical Issues of the Development of Veterinary Medicine and Breeding Technologies

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“…The presence of clinical symptoms does not correlate with the verification of tumour changes by additional studies. In particular, based on the results of the clinical, cytological and pathomorphological examination of 127 females (Mysak et al (2021) tumours of the breast gland were diagnosed in 80.3% of cases (102 animals). According to the results of histological examination, neoplasms of a malignant nature were found in 88 animals, or 69.3%, benign in 14 or 11.02 %, dysplasia was diagnosed in 25 or 19.7% of cases.…”

Section: Clinical and Pathomorphological Features Of Mastopathy In Dogsmentioning

confidence: 99%

Canine mastopathy (Overview)

Bilyi,

Khomutenko

2022

TAVM

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The etiological factors, pathogenesis and clinical and pathomorphological features of mastitis in dogs remain poorly understood, due to isolated, multidirectional studies on a small number of animals. Fibrocystic disease is diagnosed in different species of animals -small domestic, productive and laboratory animals. The clinical signs are not pathognomonic and an atypical course of the disease is possible. The potential role of mastopathy in the development of cancer has been proven, but the pathogenesis of functional dysplasia of mammary tissue, and the internal and external factors that may initiate further neoplastic transformation, remain poorly understood. Mastopathy in bitches is widespread and accounts for 8 to 30% of benign mammary gland neoplasms. Susceptibility varies considerably according to the distribution of breeds in the region. Compared to neoplasms (where the highest incidence is in animals over 7 years of age), mastitis peaks in 5-6-year-old dogs. A hormonal imbalance has been shown to be a direct cause of fibrocystic disease in bitches, and this has been experimentally confirmed in rats. The prognostic significance of estrogen and progesterone receptor expression was clarified. The importance of chronic inflammation in the pathogenesis of fibrocystic disease was shown. A high risk of mastopathy in overweight bitches has been established. Diabetes is a potential risk factor for fibrocystic disease, but further research is needed to clarify the patterns. The prospect for further research is to identify prognostic factors and key biological mechanisms to predict the course of the disease and to develop pathogenetically sound treatment protocols.

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“…Despite the significant progress in diagnostics and treatment that has been achieved over the recent several decades, mammary gland tumours remain the global cause of early death of people and veterinary patients (Mysak et al, 2018;Terajima et al, 2021). Comparative studies of the mammary gland tumours in dogs, which were conducted in different countries, should take into account possible change in the prediction due to different shares of sterilized females among the general population of dogs (Peña et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Prognostic markers of canine mammary tumours: Retrospective study of 142 cases

Kovalenko

Bilyi

Skliarov

et al. 2021

Regul. Mech. Biosyst.

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Due to relevance of the problem, prediction of biological behaviour of neoplasias in mammary glands of dogs requires using contemporary approaches to the study, first of all, of ways of dissemination of tumour cells. One of them is studying the mechanisms of migration of cancer cells out of the neoplasm tissues with further dissemination and development of metastatic sites in the regional lymphatic nodes and remote tissues. We studied the survival period of bitches with tumours of the mammary glands following regional or unilateral mastectomy. Among malignant mammary tumours in bitches, the most often diagnosed were single tumours (57.5%), which histologically were classified to carcinomas – ductal (26.9%) and mixed type (21.9%). Probability of intratumoral invasion to blood vessels equaled 12.0%, to lymph vessels – 7.8%, lymph nodes – 12.8%. It depends on the histological type of the tumour, the most aggressive potentially being сomedocarcinoma, tubulopapillary carcinoma and ductal carcinoma. Parameters of life expectancy and survival level after mastectomy depend on clinical stage of the disease (increase in the stage from the first to the third was characterized by decrease from 12.8 ± 9.5 to 9.4 ± 7.8 months), presence of angio/lymphatic invasions, presence of angiolymphatic invasion, but had no correlation with the size of the tumours. An important predictor of tumour-related death of dogs suffering neoplasias of the mammary glands is index vet-NPI, which has significant correlation with the clinical stage according to Owen and median survival. In particular, median survival in patients with the index lower than 4 exceeded the corresponding values in dogs with the index above 4 by 1.3 times. A promising direction of further research would be studying biological mechanisms of development of tumour emboli in the blood and lymph vessels, metastatic sites in lymph nodes, and also determining their role in pathogenesis of canine mammary tumours.

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Graphically x-ray and ultrasound diagnostics for monitnoring neoplasia of the mammary gland in bitches

Cited by 4 publications

References 0 publications

Mammary gland neoplasias in bitches (spreading, diagnosis, treatment methods)

Mammary gland neoplasias in bitches (spreading, diagnosis, treatment methods)

Canine mastopathy (Overview)

Prognostic markers of canine mammary tumours: Retrospective study of 142 cases

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