Graves' Disease and Hashimoto's Thyroiditis: Effects of High Doses of Antithyroid Drugs on Thyroidal Antibodies

Romaldini, João Hamilton; Rodrigues, H.F.; Werner, M. C.; Teixeira, V.L.; Novaes, M. A. S.; Werner, R. S.; Bromberg, N.

doi:10.1016/b978-0-12-731950-6.50066-8

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…However, a fall of circulating thyroid autoantibodies also was found in similar groups of patients given either MMI in combination with L-T4 or L-T4 alone (12,21), suggesting that in this model, the main active substance was actually thyroxine rather than MMI.…”

Section: Influence Of Thyroid Status On Activity Of Immune System Andmentioning

confidence: 68%

Relationship Between Graves' Ophthalmopathy and Type of Treatment of Graves' Hyperthyroidism

Marcocci

Bartalena²,

Bogazzi³

et al. 1992

Thyroid

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The relationship between the treatment of Graves' hyperthyroidism and the course of ophthalmopathy is rather unclear. Antithyroid drugs may improve eye manifestations, possibly by restoring normal thyroid function and reducing orbit-directed autoimmune reactions, whereas ophthalmopathy may worsen after radioiodine administration or thyroidectomy. This might occur because of a treatment-related release of thyroid antigens and activation of the autoimmune response that might involve the orbit. On the other hand, some authors suggest that complete thyroid ablation, either by radioiodine or surgery, might be beneficial for ophthalmopathy. However, reported effects of radioiodine and thyroidectomy on Graves' ophthalmopathy are conflicting. This may be due, at least in part, to the retrospective feature of most studies and the lack of precise evaluation of ocular involvement. Two prospective studies were performed in which patients with Graves' disease with mild or no ophthalmopathy were randomly assigned to treatment by radioiodine or subtotal thyroidectomy alone or in association with systemic glucocorticoids. Both treatments were followed by a progression of pre-existing mild ophthalmopathy in a substantial proportion of cases: glucocorticoids prevented such an exacerbation. Ophthalmopathy did not develop in patients without clinical evidence of eye disease prior to therapy. Therefore, it is recommended that a course of glucocorticoids be instituted concomitantly with radioiodine therapy or thyroidectomy in Graves' patients with some degree of ocular involvement.

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Section: Influence Of Thyroid Status On Activity Of Immune System Andmentioning

confidence: 68%

Relationship Between Graves' Ophthalmopathy and Type of Treatment of Graves' Hyperthyroidism

Marcocci

Bartalena²,

Bogazzi³

et al. 1992

Thyroid

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“…McGregor et al (17) reported a decrease in thyroid autoantibodies in patients treated with carbimazole, however, this observation has not been confirmed. In fact, Jansson et al (18) and Romaldi et al (19) have shown that even high doses of antithyroid drugs fail to cause a diminution in autoantibody production. Rennie et al (20) found lower autoantibody production in thyroglobulin-induced autoimmune thyroiditis in Iodine Is Crucialfor Obese Strain Thyroiditis the rat, however, Davies could not confirm these findings in a similar model (21).…”

Section: Discussionmentioning

confidence: 99%

Uptake and metabolism of iodine is crucial for the development of thyroiditis in obese strain chickens.

Brown¹,

Sundick²,

Dhar³

et al. 1991

J. Clin. Invest.

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To assess the importance of the role of thyroidal iodine in the pathogenesis of thyroiditis in the obese strain (OS) chicken, a model of spontaneous and severe disease, we studied the effect of antithyroid drugs that reduce thyroidal iodine or prevent its metabolism. Reduction of thyroidal iodine was achieved with KC104, an inhibitor of iodine transport and mononitrotyrosine (MNT), a drug that promotes loss of thyroidal iodine as iodotyrosines. A regimen consisting ofKC04 and MNT administration beginning in ovo and continuing after hatching reduced thyroidal infiltration to 2% of control values and decreased thyroglobulin antibody (TgAb) production for as long as 9 wk. Untreated birds had severe disease by 5 wk of age. The suppression of disease was independent of TSH, not mediated by generalized immunosuppression and reversed by excess dietary iodine. Two drugs that inhibit the metabolism of iodine, propylthiouracil (PTU) and aminotriazole, reduced thyroidal infiltration and TgAb levels, although to a lesser extent. When splenocytes from OS chickens with thyroiditis were transferred to Cornell strain (CS) chickens, a related strain that develops late onset mild disease, only the recipients that were iodine supplemented developed thyroiditis. In conclusion, autoimmune thyroiditis in an animal model can be prevented by reducing thyroidal iodine or its metabolism and optimal effects require intervention at the embryonic stage. (J. Clin. Invest.

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EVIDENCE THAT ANTITHYROID DRUGS INDUCE REMISSIONS IN GRAVEs' DISEASE BY MODULATING THYROID CELLULAR ACTIVITY

Volpé¹,

Karlsson²,

Jansson³

et al. 1986

Clinical Endocrinology

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Graves' Disease and Hashimoto's Thyroiditis: Effects of High Doses of Antithyroid Drugs on Thyroidal Antibodies

Cited by 3 publications

References 5 publications

Relationship Between Graves' Ophthalmopathy and Type of Treatment of Graves' Hyperthyroidism

Relationship Between Graves' Ophthalmopathy and Type of Treatment of Graves' Hyperthyroidism

Uptake and metabolism of iodine is crucial for the development of thyroiditis in obese strain chickens.

EVIDENCE THAT ANTITHYROID DRUGS INDUCE REMISSIONS IN GRAVEs' DISEASE BY MODULATING THYROID CELLULAR ACTIVITY

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