Gray Matter Atrophy and Neurological Deficits in Patients with Carbon Monoxide Poisoning

Abstract

White matter damage in patients with carbon monoxide (CO) poisoning have been extensively reported in previous studies, but neurological deficits-associated gray matter volume (GMV) changes are not well explored. Forty-one CO poisoning patients and 36 healthy controls were enrolled in this study. All subjects underwent 3D T1WI and cognition and motor function assessment. GMV change patterns of patients were explored using Voxel-based morphometry processing. This study would provide a simple neuroimaging biomarker to identify the brain anatomical signatures underlying neurological deficits in CO poisoning, and thus facilitate the ongoing effort of knowing of the neuropathologic mechanism happened in these patients.