Gray Matter Matters in Mild Traumatic Brain Injury

Bigler, Erin D.

doi:10.1212/wnl.0000000000206835

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2024

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Cited by 2 publications

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Microstructural Alterations of Gray and White Matter in Active Young Boxers with Sports-Related Concussions

Huang,

Yan,

Zheng

et al. 2024

Journal of Neurotrauma

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Microstructural Alterations of Gray and White Matter in Active Young Boxers with Sports-Related Concussions

Huang,

Yan,

Zheng

et al. 2024

Journal of Neurotrauma

View full text Add to dashboard Cite

MRI-T2 Relaxometry is Increased in Mild Traumatic Brain Injury: Indications of Acute Brain Abnormalities after Injury

Bedggood,

Essex,

Theadom

et al. 2024

Preprint

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IntroMild traumatic brain injury (mTBI) is a common condition, particularly pervasive in contact sports environments. A range of symptoms can accompany this type of injury and negatively impact people’s lives. As mTBI diagnosis and recovery largely rely on subjective reports, more objective injury markers are needed.MethodsThe current study compared structural brain MRI-T2 relaxometry between a group of 40 athletes with mTBI within 14 days of injury and 40 age and sex-matched controls.ResultsWhole-brain average T2 relaxometry increased for the mTBI group compared to controls (p< 0.001), with increased T2 relaxometry particularly prominent in superior cortical regions (e.g. somatomotor and dorsal attention areas).ConclusionWe hypothesise that this finding indicates subtle brain inflammation acutely following mTBI and could represent an objective injury marker to diagnose and monitor mTBI. Future research should validate this potential injury marker with other data types, such as blood biomarkers or histological samples.

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Gray Matter Matters in Mild Traumatic Brain Injury

Cited by 2 publications

References 6 publications

Microstructural Alterations of Gray and White Matter in Active Young Boxers with Sports-Related Concussions

Microstructural Alterations of Gray and White Matter in Active Young Boxers with Sports-Related Concussions

MRI-T2 Relaxometry is Increased in Mild Traumatic Brain Injury: Indications of Acute Brain Abnormalities after Injury

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