Greater financial toxicity correlates with increased psychological distress and lower quality of life among Turkish cancer patients

Yücel, Kadriye Bir; Özay, Zeynep Irem; Sütçüoğlu, Osman; Yazıcı, Ozan; Üner, Aytuğ; Günel, Nazan; Özet, Ahmet; Tahtacı, Gözde; Özdemir, Nuriye

doi:10.1007/s00520-023-07586-w

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…And secondly, a systematic review demonstrated relatively clear associations exist between FT and stress, spiritual suffering, fear of recurrence, and overall psychological symptoms [48]. Numerous studies also found positive associations between increases in FT and higher levels of depression and anxiety [49,50]. It is not controversial to say that this in turn affect physical symptoms such as sleep disturbance and fatigue, and ultimately result in inferior life quality.…”

Section: Discussionmentioning

confidence: 99%

“…And each item was given on a Likert-type format with 5 options (1 = none of the time, 5 = all of the time). The total score ranges from 10 to 50, with the following stages: none (10)(11)(12)(13)(14)(15)(16)(17)(18)(19), mild (20)(21)(22)(23)(24)(25)(26)(27)(28)(29), moderate (30)(31)(32)(33)(34)(35)(36)(37)(38)(39), and severe (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). Wu and Jiang translated it into Chinese with satisfactory internal consistency coe cient (Cronbach's α = 0.91) [38].…”

Section: Self-perceived Burden Scale (Spbs)mentioning

confidence: 99%

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Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Zhang,

Xu,

Yang

et al. 2024

Preprint

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Background Although immunotherapy has the potential to prolong the median survival time and overall survival of patients with lung cancer, it is also a driver of immune related adverse events, which may directly affect the therapeutic effect and reduce quality of life (QOL). Attention to measure QOL in lung cancer patients undergoing immunotherapy is under-explored because of the therapy’s relative novelty. And a great deal of empirical researches has indicated the important influence of financial toxicity (FT) and self-perceived burden (SPB) on QOL. However, yet no research has ever clarified the relationship among FT, SPB, and QOL simultaneously. Hence, the purpose of this study is to understand the level of QOL of lung cancer patients undergoing immunotherapy, and attempt to clarify the potential mediating roles of SPB on the relationship between FT and QOL. Methods A convenience sample of 342 lung cancer patients undergoing immunotherapy was recruited from a cancer hospital from October 2022 to April 2023 in this cross-sectional study. Participants were requested to complete the structured questionnaires: sociodemographic and clinical questionnaire, Functional Assessment of Cancer Therapy–Lung (FACT-L), Self -Perceived Burden Scale (SPBS) and COmprehensive Score for financial Toxicity (COST). Data were subjected to Pearson correlation analysis and bootstrapping analysis in the structural equation modelling. Results The total score of FACT-L was (79.90 ± 15.84) points in 322 lung cancer patients administrated with immunotherapy. FT (β = 0.37, P < 0.01) and SPB (β = -0.27, P < 0.01) had a direct effect on QOL. In addition, SPB partly mediated the association between FT and QOL, and the standardized indirect effect was 0.19, accounting for 33.9% of the total effect. Conclusions The present study revealed that lung cancer patients undergoing immunotherapy experienced a lower QOL. And higher financial burden resulted in greater self-perceived burden, thus associated with inferior QOL. It is imperative for healthcare providers to routinely assessed QOL, financial toxicity or risk and self- perceived burden for lung cancer patients undergoing immunotherapy, and assist those patients in understanding the potential financial risk of each choice and help them take more active roles in their routine clinical care.

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Section: Discussionmentioning

confidence: 99%

Section: Self-perceived Burden Scale (Spbs)mentioning

confidence: 99%

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Zhang,

Xu,

Yang

et al. 2024

Preprint

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“…While out-of-pocket expenditures vary widely within the US, the high risk of financial toxicity with cancer patients is international, including for countries with universal or individual payer systems. [43][44][45][46][47] In fact, financial toxicity is significantly greater outside the US, in countries with lower average incomes. 48 While COST is widely-used, and a psychometrically validated measure of financial toxicity, its design and use maybe specific to the US healthcare context.…”

Section: Discussionmentioning

confidence: 99%

Severity of Financial Toxicity for Patients Receiving Palliative Radiation Therapy

Harris

Harada

et al. 2023

Am J Hosp Palliat Care

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Introduction: Financial toxicity has negative implications for patient well-being and health outcomes. There is a gap in understanding financial toxicity for patients undergoing palliative radiotherapy (RT). Methods: A review of patients treated with palliative RT was conducted from January 2021 to December 2022. The FACIT-COST (COST) was measured (higher scores implying better financial well-being). Financial toxicity was graded according to previously suggested cutoffs: Grade 0 (score ≥26), Grade 1 (14-25), Grade 2 (1-13), and Grade 3 (0). FACIT-TS-G was used for treatment satisfaction, and EORTC QLQ-C30 was assessed for global health status and functional scales. Results: 53 patients were identified. Median COST was 25 (range 0-44), 49% had Grade 0 financial toxicity, 32% Grade 1, 15% Grade 2, and 4% Grade 3. Overall, cancer caused financial hardship among 45%. Higher COST was weakly associated with higher global health status/Quality of Life (QoL), physical functioning, role functioning, and cognitive functioning; moderately associated with higher social functioning; and strongly associated with improved emotional functioning. Higher income or Medicare or private coverage (rather than Medicaid) was associated with less financial toxicity, whereas an underrepresented minority background or a non-English language preference was associated with greater financial toxicity. A multivariate model found that higher area income (HR .80, P = .007) and higher cognitive functioning (HR .96, P = .01) were significantly associated with financial toxicity. Conclusions: Financial toxicity was seen in approximately half of patients receiving palliative RT. The highest risk groups were those with lower income and lower cognitive functioning. This study supports the measurement of financial toxicity by clinicians.

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Profiles of financial toxicity and influencing factors among cancer patients: A latent profile analysis

Xiao,

Zhong,

Xiao

et al. 2024

Research in Social and Administrative Pharmacy

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Greater financial toxicity correlates with increased psychological distress and lower quality of life among Turkish cancer patients

Cited by 6 publications

References 49 publications

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Severity of Financial Toxicity for Patients Receiving Palliative Radiation Therapy

Profiles of financial toxicity and influencing factors among cancer patients: A latent profile analysis

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