Green and cost effective synthesis of silver nanoparticles from endangered medicinal plant Withania coagulans and their potential biomedical properties

Tripathi, Deepika; Modi, Arusha; Narayan, Gopeshwar; Pandey-Rai, Shashi

doi:10.1016/j.msec.2019.02.113

Cited by 129 publications

(60 citation statements)

References 45 publications

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“…The constituents of W. coagulans include free amino acids, essential oils, steroidal lactones and esterases, widely used for their pharmacological activities [22]. A few studies have also recommended the use of withanolide, withaferin and other biological entities found in W. coagulans for their bioreducing potential in the synthesis of nanoparticles [23,24], and studies have reported the eco-friendly and less toxic preparation of nanoparticles and pharmacological studies using W. coagulans components [25]. So far, all these biological activities were tested using crude extracts containing complex mixtures of active biomolecules and the solvents-based screening, fractionation and functionalization of bioactive compounds has not been previously reported.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

et al. 2020

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Withania coagulans contains a complex mixture of various bioactive compounds. In order to reduce the complexity of the plant extract to purify its phytochemical biomolecules, a novel fractionation strategy using different solvent combination ratios was applied to isolate twelve bioactive fractions. These fractions were tested for activity in the biogenic synthesis of cobalt oxide nanoparticles, biofilm and antifungal activities. The results revealed that plant extract with bioactive fractions in 30% ratio for all solvent combinations showed more potent bioreducing power, according to the observed color changes and the appearance of representative absorption peaks at 500–510 nm in the UV-visible spectra which confirm the synthesis of cobalt oxide nanoparticles (Co3O4 NPs). XRD diffraction was used to define the crystal structure, size and phase composition of the products. The fractions obtained using 90% methanol/hexane and 30% methanol/hexane showed more effectiveness against biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus so these fractions could potentially be used to treat bacterial infections. The 90% hexane/H2O fraction showed excellent antifungal activity against Aspergillus niger and Candida albicans, while the 70% methanol/hexane fraction showed good antifungal activity for C. albicans, so these fractions are potentially useful for the treatment of various fungal infections. On the whole it was concluded that fractionation based on effective combinations of methanol/hexane was useful to investigate and study bioactive compounds, and the active compounds from these fractions may be further purified and tested in various clinical trials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

et al. 2020

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“…Effect of AgNPs against wide range of cancer cell lines was extensively reported. Death of cancer cells was caused by cytotoxic [120], anti-proliferative [41,117], anti-metastatic [121] and apoptotic [122] mechanisms. AgNPs of smaller sizes can freely penetrate into the cells through easy diffusion or pass through receptors, ion channels and transporters across the membrane.…”

Section: Anticancermentioning

confidence: 99%

A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

Velidandi¹,

Dahariya²,

Pabbathi³

et al. 2020

NanoWorld

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In recent years, fabrication of AgNPs via plant extracts has gained much attention because of being environmentally friendly, non-hazardous and cost effective. The bio-fabrication of AgNPs using plant extracts as reducing, capping and stabilizing agents includes simpler, safer, less-toxic and energy efficient. AgNPs have been widely applied in numerous fields due to their bio-compatibility, multifunctionality, solubility, high stability, therapeutic and adhesive properties. This review focuses on the advantages of AgNPs synthesis using plant extracts and its applications in various fields for the betterment of mankind and environment with numerous examples and also highlights on explaining possible fundamental mechanisms involved in antimicrobial and anticancer activities of plant extract synthesized AgNPs.

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“…Research abounds where phytoconstituents in various plants parts have been exploited for biogenic synthesis of AgNPs. 22,35,36 Biogenic synthesis of nanoparticles follows the general nucleation and growth mechanism. These reactions are kick-started ones the Gibb's free energy changes of the reaction are less than zero.…”

Section: Synthesis Of Cape-agnpsmentioning

confidence: 99%

Centella asiatica phenolic extract-mediated bio-fabrication of silver nanoparticles: characterization, reduction of industrially relevant dyes in water and antimicrobial activities against foodborne pathogens

et al. 2019

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Green and cost effective synthesis of silver nanoparticles from endangered medicinal plant Withania coagulans and their potential biomedical properties

Cited by 129 publications

References 45 publications

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

A Review on Synthesis, Applications, Toxicity, Risk Assessment and Limitations of Plant Extracts Synthesized Silver Nanoparticles

Centella asiatica phenolic extract-mediated bio-fabrication of silver nanoparticles: characterization, reduction of industrially relevant dyes in water and antimicrobial activities against foodborne pathogens

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