Green cannabigerol purification through simulated moving bed chromatography

Luca, Chiara De; Krauke, Yannick; Stephan, Svea; Greco, Giorgia; Compagnin, Greta; Buratti, Alessandro; Cavazzini, Alberto; Catani, Martina; Felletti, Simona

doi:10.1016/j.greeac.2023.100066

Cited by 3 publications

(1 citation statement)

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“…Normal phase elution mode has been successfully used for cannabinoids purification, with optimal results and fast separations [ 8 , 14 ]. In addition, cannabinoid solubility in solvents such as hexane or heptane is significantly large (e.g.…”

Section: Introductionmentioning

confidence: 99%

Sustainable cannabinoids purification through twin-column recycling chromatography and green solvents

Compagnin,

De Luca,

Nosengo

et al. 2024

Anal Bioanal Chem

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In the present study, twin-column recycling chromatography has been employed for the purification of a Cannabis extract by using a green solvent, ethanol, as the mobile phase. In particular, the complete removal of the psychoactive tetrahydrocannabinol (THC) from a Cannabis extract rich in cannabidiol (CBD) was achieved under continuous conditions. The performance of the method, in terms of compound purity, recovery, productivity and solvent consumption, was compared to that of traditional batch operations showing the potential of the twin-column recycling approach. The employment of a theoretical model to predict the band profiles of the two compounds during the recycling process has facilitated method development, thus further contributing to process sustainability by avoiding trial and error attempts or at least decreasing the number of steps significantly. Graphical abstract

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Section: Introductionmentioning

confidence: 99%