Green capsule phase microextraction employing hydrophobic monolithic sol-gel octadecyl siloxane platforms for the monitoring of organophosphorus pesticides in environmental water samples

Manousi, Natalia; Ferracane, Antonio; Kabir, Abuzar; Furton, Kenneth G.; Tranchida, Peter Q.; Zachariadis, George A.; Płotka‐Wasylka, Justyna; Mondello, Luigi; Samanidou, Victoria; Rosenberg, Erwin

doi:10.1016/j.scp.2022.100892

Cited by 3 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under optimum extraction conditions, the efficiency of the sol–gel Carbowax 20 M/ IL-based CPME platform was compared with C 18 encapsulated media which is a widely used sorbent for this kind of analysis. The synthesis and characterization of sol–gel C 18 CPME media has been reported elsewhere [ 16 , 32 ]. Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Fabricating a designer capsule phase microextraction platform based on sol–gel Carbowax 20M-zwitterionic ionic liquid composite sorbent for the extraction of lipid-lowering drugs from human urine samples

Kechagia,

Manousi,

Kabir

et al. 2023

Microchim Acta

Self Cite

View full text Add to dashboard Cite

A sol–gel Carbowax 20 M/3-[(3-Cholamidopropyl) dimethyl ammonio]-1-propanesulfonate composite sorbent-based capsule phase microextraction device has been fabricated and characterized for the determination of four statins (pravastatin, rosuvastatin, pitavastatin, and atorvastatin) in human urine. The presence of ionizable carboxyl functional groups in statins requires pH adjustment of the sample matrix to ensure that the target molecules are in their protonated form (pH should be 2 units below their pKa values) which not only is cumbersome but also risks unintended contamination of the sample. This challenge was addressed by introducing zwitterionic ionic liquid in addition to neutral, polar Carbowax 20 M polymer in the sol–gel-derived composite sorbent. As such, the composite zwitterionic multi-modal sorbent can simultaneously extract neutral, cationic, and anionic species. This particular attribute of the composite sorbent eliminates the necessity of the matrix pH adjustment and consequently simplifies the overall sample preparation workflow. Various experimental parameters such as the sample amount, extraction time, salt addition, stirring rate, and elution solvent type that may affect the extraction performance of the statins were investigated using a central composite design and the one-parameter-at-a-time approach. The analytes and the internal standard were separated on a C18 column with gradient elution using phosphate buffer (20 mM, pH 3) and acetonitrile as mobile phase. The analytes were detected at 237 nm. The method was validated, and linearity was observed in the range 0.10–2.0 μg mL−1 for all compounds. The method precision was better 9.9% and 10.4% for intra-day and inter-day, respectively, while the relative recoveries were acceptable, ranging between 83.4 and 116% in all cases. Method greenness was assessed using the ComplexGAPI index. Finally, the method’s applicability was demonstrated in the determination of the statins in authentic human urine after oral administration of pitavastatin and rosuvastatin-containing tablets. Graphical abstract

show abstract

Section: Resultsmentioning

confidence: 99%

Fabricating a designer capsule phase microextraction platform based on sol–gel Carbowax 20M-zwitterionic ionic liquid composite sorbent for the extraction of lipid-lowering drugs from human urine samples

Kechagia,

Manousi,

Kabir

et al. 2023

Microchim Acta

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides, the employment of chemometric models increases the greenness of the analysis by increasing the number of analytes that can be simultaneously measured in a single analysis, reducing the need for additional tests and consumables. Furthermore, the blueness profiles of the CRACLS and SRACLS models were also evaluated using the blue applicability grade index (BAGI) to assess their analytical applicability [29]. The results of the F I G U R E 4 The assessment of the (a) greenness of the developed method using the AGREE tool to determine its environmental impact and (b) blueness of the developed method using the BAGI tool to determine its analytical practicability.…”

Section: Greenness and Blueness Profiles' Evaluationmentioning

confidence: 99%

Determination of valsartan and pitavastatin using synchronous spectrofluorimetry and augmented least squares chemometric models: A comparative study with greenness and blueness assessment

Almalki,

Abduljabbar,

Alzhrani

et al. 2024

Luminescence

View full text Add to dashboard Cite

Hypertension and hyperlipidemia are two common conditions that require effective management to reduce the risk of cardiovascular diseases. Among the medications commonly used for the treatment of these conditions, valsartan and pitavastatin have shown significant efficacy in lowering blood pressure and cholesterol levels, respectively. In this study, synchronous spectrofluorimetry coupled to chemometric analysis tools, specifically concentration residual augmented classical least squares (CRACLS) and spectral residual augmented classical least squares (SRACLS), was employed for the determination of valsartan and pitavastatin simultaneously. The developed models exhibited excellent predictive performance with relative root mean square error of prediction (RRMSEP) of 2.253 and 2.1381 for valsartan and pitavastatin, respectively. Hence, these models were successfully applied to the analysis of synthetic samples and commercial formulations as well as plasma samples with high accuracy and precision. Besides, the greenness and blueness profiles of the determined samples were also evaluated to assess their environmental impact and analytical practicability. The results demonstrated excellent greenness and blueness scores with AGREE score of 0.7 and BAGI score of 75 posing the proposed method as reliable and sensitive approach for the determination of valsartan and pitavastatin with potential applications in pharmaceutical quality control, bioanalytical studies, and therapeutic drug monitoring.

show abstract

“…The more popular SPμE configurations that facilitate sorbent removal include sorbent adjoined to various solid materials. Manousi and co-workers 43 synthesized a monolithic sol–gel octadecyl siloxane sorbent encapsulated in porous polypropylene capsules for the extraction of organophosphorus pesticides from environmental water samples by the technique called capsule-phase microextraction (CPμE). Beside the sorbent, the extraction device included a porous membrane and a magnet.…”

Section: Main Strategies In Performing Green Chemical Analysismentioning

confidence: 99%

Green chemical analysis: main principles and current efforts towards greener analytical methodologies

Branković

2023

Anal. Methods

View full text Add to dashboard Cite

show abstract

Green capsule phase microextraction employing hydrophobic monolithic sol-gel octadecyl siloxane platforms for the monitoring of organophosphorus pesticides in environmental water samples

Cited by 3 publications

References 38 publications

Fabricating a designer capsule phase microextraction platform based on sol–gel Carbowax 20M-zwitterionic ionic liquid composite sorbent for the extraction of lipid-lowering drugs from human urine samples

Fabricating a designer capsule phase microextraction platform based on sol–gel Carbowax 20M-zwitterionic ionic liquid composite sorbent for the extraction of lipid-lowering drugs from human urine samples

Determination of valsartan and pitavastatin using synchronous spectrofluorimetry and augmented least squares chemometric models: A comparative study with greenness and blueness assessment

Green chemical analysis: main principles and current efforts towards greener analytical methodologies

Contact Info

Product

Resources

About